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Q00384

- ALKH_ZYMMO

UniProt

Q00384 - ALKH_ZYMMO

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Protein
KHG/KDPG aldolase
Gene
eda, kdgA, ZMO0997
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411 By similarity
Active sitei45 – 451 By similarity
Active sitei128 – 1281Schiff-base intermediate with KHG or pyruvate By similarity

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
  2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00227.
UPA00856; UER00829.

Names & Taxonomyi

Protein namesi
Recommended name:
KHG/KDPG aldolase
Including the following 2 domains:
4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
Alternative name(s):
2-keto-4-hydroxyglutarate aldolase
Short name:
KHG-aldolase
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
2-keto-3-deoxy-6-phosphogluconate aldolase
Short name:
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:eda
Synonyms:kdgA
Ordered Locus Names:ZMO0997
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208KHG/KDPG aldolase
PRO_0000201044Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi264203.ZMO0997.

Structurei

3D structure databases

ProteinModelPortaliQ00384.

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.

Phylogenomic databases

eggNOGiCOG0800.
HOGENOMiHOG000233114.
KOiK01625.
OMAiSWLVPND.
OrthoDBiEOG67DPKT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00384-1 [UniParc]FASTAAdd to Basket

« Hide

MRDIDSVMRL APVMPVLVIE DIADAKPIAE ALVAGGLNVL EVTLRTPCAL    50
EAIKIMKEVP GAVVGAGTVL NAKMLDQAQE AGCEFFVSPG LTADLGKHAV 100
AQKAALLPGV ANAADVMLGL DLGLDRFKFF PAENIGGLPA LKSMASVFRQ 150
VRFCPTGGIT PTSAPKYLEN PSILCVGGSW VVPAGKPDVA KITALAKEAS 200
AFKRAAVA 208
Length:208
Mass (Da):21,505
Last modified:February 15, 2005 - v2
Checksum:i1685B45A7DFB57B4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 44MRDI → M in CAA41258. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58364 Genomic DNA. Translation: CAA41258.1.
AE008692 Genomic DNA. Translation: AAV89621.1.
RefSeqiYP_162732.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89621; AAV89621; ZMO0997.
GeneIDi3188481.
KEGGizmo:ZMO0997.
PATRICi32567292. VBIZymMob102260_0944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58364 Genomic DNA. Translation: CAA41258.1 .
AE008692 Genomic DNA. Translation: AAV89621.1 .
RefSeqi YP_162732.1. NC_006526.2.

3D structure databases

ProteinModelPortali Q00384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO0997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV89621 ; AAV89621 ; ZMO0997 .
GeneIDi 3188481.
KEGGi zmo:ZMO0997.
PATRICi 32567292. VBIZymMob102260_0944.

Phylogenomic databases

eggNOGi COG0800.
HOGENOMi HOG000233114.
KOi K01625.
OMAi SWLVPND.
OrthoDBi EOG67DPKT.

Enzyme and pathway databases

UniPathwayi UPA00227 .
UPA00856 ; UER00829 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view ]
Pfami PF01081. Aldolase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01182. eda. 1 hit.
PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization and expression of the Zymononas mobilis eda gene that encodes 2-keto-3-deoxy-6-phosphogluconate aldolase of the Entner-Doudoroff pathway."
    Conway T., Fliege R., Jones-Kilpatrick D., Liu J., Barnell W.O., Egan S.E.
    Mol. Microbiol. 5:2901-2911(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiALKH_ZYMMO
AccessioniPrimary (citable) accession number: Q00384
Secondary accession number(s): Q5NNT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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