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Q00384

- ALKH_ZYMMO

UniProt

Q00384 - ALKH_ZYMMO

Protein

KHG/KDPG aldolase

Gene

eda

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
    2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411PROSITE-ProRule annotation
    Active sitei45 – 451PROSITE-ProRule annotation
    Active sitei128 – 1281Schiff-base intermediate with KHG or pyruvatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
    2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00227.
    UPA00856; UER00829.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KHG/KDPG aldolase
    Including the following 2 domains:
    4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
    Alternative name(s):
    2-keto-4-hydroxyglutarate aldolase
    Short name:
    KHG-aldolase
    2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
    Alternative name(s):
    2-keto-3-deoxy-6-phosphogluconate aldolase
    Short name:
    KDPG-aldolase
    Phospho-2-dehydro-3-deoxygluconate aldolase
    Phospho-2-keto-3-deoxygluconate aldolase
    Gene namesi
    Name:eda
    Synonyms:kdgA
    Ordered Locus Names:ZMO0997
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208KHG/KDPG aldolasePRO_0000201044Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.

    Protein-protein interaction databases

    STRINGi264203.ZMO0997.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00384.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KHG/KDPG aldolase family.Curated

    Phylogenomic databases

    eggNOGiCOG0800.
    HOGENOMiHOG000233114.
    KOiK01625.
    OMAiSWLVPND.
    OrthoDBiEOG67DPKT.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view]
    PfamiPF01081. Aldolase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01182. eda. 1 hit.
    PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q00384-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDIDSVMRL APVMPVLVIE DIADAKPIAE ALVAGGLNVL EVTLRTPCAL    50
    EAIKIMKEVP GAVVGAGTVL NAKMLDQAQE AGCEFFVSPG LTADLGKHAV 100
    AQKAALLPGV ANAADVMLGL DLGLDRFKFF PAENIGGLPA LKSMASVFRQ 150
    VRFCPTGGIT PTSAPKYLEN PSILCVGGSW VVPAGKPDVA KITALAKEAS 200
    AFKRAAVA 208
    Length:208
    Mass (Da):21,505
    Last modified:February 15, 2005 - v2
    Checksum:i1685B45A7DFB57B4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 44MRDI → M in CAA41258. (PubMed:1809834)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58364 Genomic DNA. Translation: CAA41258.1.
    AE008692 Genomic DNA. Translation: AAV89621.1.
    RefSeqiYP_162732.1. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV89621; AAV89621; ZMO0997.
    GeneIDi3188481.
    KEGGizmo:ZMO0997.
    PATRICi32567292. VBIZymMob102260_0944.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58364 Genomic DNA. Translation: CAA41258.1 .
    AE008692 Genomic DNA. Translation: AAV89621.1 .
    RefSeqi YP_162732.1. NC_006526.2.

    3D structure databases

    ProteinModelPortali Q00384.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO0997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV89621 ; AAV89621 ; ZMO0997 .
    GeneIDi 3188481.
    KEGGi zmo:ZMO0997.
    PATRICi 32567292. VBIZymMob102260_0944.

    Phylogenomic databases

    eggNOGi COG0800.
    HOGENOMi HOG000233114.
    KOi K01625.
    OMAi SWLVPND.
    OrthoDBi EOG67DPKT.

    Enzyme and pathway databases

    UniPathwayi UPA00227 .
    UPA00856 ; UER00829 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view ]
    Pfami PF01081. Aldolase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01182. eda. 1 hit.
    PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization and expression of the Zymononas mobilis eda gene that encodes 2-keto-3-deoxy-6-phosphogluconate aldolase of the Entner-Doudoroff pathway."
      Conway T., Fliege R., Jones-Kilpatrick D., Liu J., Barnell W.O., Egan S.E.
      Mol. Microbiol. 5:2901-2911(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.

    Entry informationi

    Entry nameiALKH_ZYMMO
    AccessioniPrimary (citable) accession number: Q00384
    Secondary accession number(s): Q5NNT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3