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Q00384

- ALKH_ZYMMO

UniProt

Q00384 - ALKH_ZYMMO

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Protein

KHG/KDPG aldolase

Gene

eda

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411PROSITE-ProRule annotation
Active sitei45 – 451PROSITE-ProRule annotation
Active sitei128 – 1281Schiff-base intermediate with KHG or pyruvatePROSITE-ProRule annotation

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
  2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00227.
UPA00856; UER00829.

Names & Taxonomyi

Protein namesi
Recommended name:
KHG/KDPG aldolase
Including the following 2 domains:
4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
Alternative name(s):
2-keto-4-hydroxyglutarate aldolase
Short name:
KHG-aldolase
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
2-keto-3-deoxy-6-phosphogluconate aldolase
Short name:
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:eda
Synonyms:kdgA
Ordered Locus Names:ZMO0997
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208KHG/KDPG aldolasePRO_0000201044Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi264203.ZMO0997.

Structurei

3D structure databases

ProteinModelPortaliQ00384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.Curated

Phylogenomic databases

eggNOGiCOG0800.
HOGENOMiHOG000233114.
KOiK01625.
OMAiSWLVPND.
OrthoDBiEOG67DPKT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00384-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDIDSVMRL APVMPVLVIE DIADAKPIAE ALVAGGLNVL EVTLRTPCAL
60 70 80 90 100
EAIKIMKEVP GAVVGAGTVL NAKMLDQAQE AGCEFFVSPG LTADLGKHAV
110 120 130 140 150
AQKAALLPGV ANAADVMLGL DLGLDRFKFF PAENIGGLPA LKSMASVFRQ
160 170 180 190 200
VRFCPTGGIT PTSAPKYLEN PSILCVGGSW VVPAGKPDVA KITALAKEAS

AFKRAAVA
Length:208
Mass (Da):21,505
Last modified:February 15, 2005 - v2
Checksum:i1685B45A7DFB57B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 44MRDI → M in CAA41258. (PubMed:1809834)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58364 Genomic DNA. Translation: CAA41258.1.
AE008692 Genomic DNA. Translation: AAV89621.1.
RefSeqiYP_162732.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89621; AAV89621; ZMO0997.
GeneIDi3188481.
KEGGizmo:ZMO0997.
PATRICi32567292. VBIZymMob102260_0944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58364 Genomic DNA. Translation: CAA41258.1 .
AE008692 Genomic DNA. Translation: AAV89621.1 .
RefSeqi YP_162732.1. NC_006526.2.

3D structure databases

ProteinModelPortali Q00384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO0997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV89621 ; AAV89621 ; ZMO0997 .
GeneIDi 3188481.
KEGGi zmo:ZMO0997.
PATRICi 32567292. VBIZymMob102260_0944.

Phylogenomic databases

eggNOGi COG0800.
HOGENOMi HOG000233114.
KOi K01625.
OMAi SWLVPND.
OrthoDBi EOG67DPKT.

Enzyme and pathway databases

UniPathwayi UPA00227 .
UPA00856 ; UER00829 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view ]
Pfami PF01081. Aldolase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01182. eda. 1 hit.
PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization and expression of the Zymononas mobilis eda gene that encodes 2-keto-3-deoxy-6-phosphogluconate aldolase of the Entner-Doudoroff pathway."
    Conway T., Fliege R., Jones-Kilpatrick D., Liu J., Barnell W.O., Egan S.E.
    Mol. Microbiol. 5:2901-2911(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiALKH_ZYMMO
AccessioniPrimary (citable) accession number: Q00384
Secondary accession number(s): Q5NNT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3