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Protein

AP-2 complex subunit sigma

Gene

APS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.1 Publication

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • intracellular protein transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Endocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31691-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit sigma
Alternative name(s):
Adaptin small chain
Clathrin assembly protein 2 sigma small chain
Clathrin coat assembly protein AP17
Clathrin coat-associated protein AP17
Plasma membrane adaptor AP-2 17 kDa protein
Sigma2-adaptin
Gene namesi
Name:APS2
Synonyms:YAP17
Ordered Locus Names:YJR058C
ORF Names:J1720
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR058C.
SGDiS000003819. APS2.

Subcellular locationi

GO - Cellular componenti

  • AP-2 adaptor complex Source: SGD
  • clathrin-coated vesicle Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147AP-2 complex subunit sigmaPRO_0000193814Add
BLAST

Proteomic databases

MaxQBiQ00381.

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2). Interacts with APL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APL3P380653EBI-2608,EBI-2181

Protein-protein interaction databases

BioGridi33815. 30 interactions.
DIPiDIP-5093N.
IntActiQ00381. 6 interactions.
MINTiMINT-485760.

Structurei

3D structure databases

ProteinModelPortaliQ00381.
SMRiQ00381. Positions 3-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00650000094465.
HOGENOMiHOG000185227.
InParanoidiQ00381.
KOiK11827.
OMAiMVMDEMF.
OrthoDBiEOG092C59LG.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQFILCFN KQGVVRLVRW FDVHSSDPQR SQDAIAQIYR LISSRDHKHQ
60 70 80 90 100
SNFVEFSDST KLIYRRYAGL YFVMGVDLLD DEPIYLCHIH LFVEVLDAFF
110 120 130 140
GNVCELDIVF NFYKVYMIMD EMFIGGEIQE ISKDMLLERL SILDRLD
Length:147
Mass (Da):17,373
Last modified:April 1, 1993 - v1
Checksum:iDFFD1A567532AAD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37193 Genomic DNA. Translation: AAA35225.1.
Z49558 Genomic DNA. Translation: CAA89586.1.
L47993 Genomic DNA. Translation: AAB39284.1.
AY557893 Genomic DNA. Translation: AAS56219.1.
BK006943 Genomic DNA. Translation: DAA08845.1.
PIRiC40535.
RefSeqiNP_012592.1. NM_001181716.1.

Genome annotation databases

EnsemblFungiiYJR058C; YJR058C; YJR058C.
GeneIDi853521.
KEGGisce:YJR058C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37193 Genomic DNA. Translation: AAA35225.1.
Z49558 Genomic DNA. Translation: CAA89586.1.
L47993 Genomic DNA. Translation: AAB39284.1.
AY557893 Genomic DNA. Translation: AAS56219.1.
BK006943 Genomic DNA. Translation: DAA08845.1.
PIRiC40535.
RefSeqiNP_012592.1. NM_001181716.1.

3D structure databases

ProteinModelPortaliQ00381.
SMRiQ00381. Positions 3-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33815. 30 interactions.
DIPiDIP-5093N.
IntActiQ00381. 6 interactions.
MINTiMINT-485760.

Proteomic databases

MaxQBiQ00381.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR058C; YJR058C; YJR058C.
GeneIDi853521.
KEGGisce:YJR058C.

Organism-specific databases

EuPathDBiFungiDB:YJR058C.
SGDiS000003819. APS2.

Phylogenomic databases

GeneTreeiENSGT00650000094465.
HOGENOMiHOG000185227.
InParanoidiQ00381.
KOiK11827.
OMAiMVMDEMF.
OrthoDBiEOG092C59LG.

Enzyme and pathway databases

BioCyciYEAST:G3O-31691-MONOMER.

Miscellaneous databases

PROiQ00381.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP2S_YEAST
AccessioniPrimary (citable) accession number: Q00381
Secondary accession number(s): D6VWM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1390 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.