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Protein

AP-2 complex subunit sigma

Gene

APS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.1 Publication

Miscellaneous

Present with 1390 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • intracellular protein transport Source: SGD

Keywordsi

Biological processEndocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31691-MONOMER
ReactomeiR-SCE-8856825 Cargo recognition for clathrin-mediated endocytosis
R-SCE-8866427 VLDLR internalisation and degradation
R-SCE-8964038 LDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit sigma
Alternative name(s):
Adaptin small chain
Clathrin assembly protein 2 sigma small chain
Clathrin coat assembly protein AP17
Clathrin coat-associated protein AP17
Plasma membrane adaptor AP-2 17 kDa protein
Sigma2-adaptin
Gene namesi
Name:APS2
Synonyms:YAP17
Ordered Locus Names:YJR058C
ORF Names:J1720
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR058C
SGDiS000003819 APS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938141 – 147AP-2 complex subunit sigmaAdd BLAST147

Proteomic databases

MaxQBiQ00381
PaxDbiQ00381
PRIDEiQ00381

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2). Interacts with APL1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33815, 48 interactors
DIPiDIP-5093N
IntActiQ00381, 10 interactors
MINTiQ00381
STRINGi4932.YJR058C

Structurei

3D structure databases

ProteinModelPortaliQ00381
SMRiQ00381
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00910000146115
HOGENOMiHOG000185227
InParanoidiQ00381
KOiK11827
OMAiSFFDNVC
OrthoDBiEOG092C59LG

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR027156 APS2
IPR000804 Clathrin_sm-chain_CS
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PTHR11753:SF6 PTHR11753:SF6, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588 AP_complex_sigma, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit

Sequencei

Sequence statusi: Complete.

Q00381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQFILCFN KQGVVRLVRW FDVHSSDPQR SQDAIAQIYR LISSRDHKHQ
60 70 80 90 100
SNFVEFSDST KLIYRRYAGL YFVMGVDLLD DEPIYLCHIH LFVEVLDAFF
110 120 130 140
GNVCELDIVF NFYKVYMIMD EMFIGGEIQE ISKDMLLERL SILDRLD
Length:147
Mass (Da):17,373
Last modified:April 1, 1993 - v1
Checksum:iDFFD1A567532AAD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37193 Genomic DNA Translation: AAA35225.1
Z49558 Genomic DNA Translation: CAA89586.1
L47993 Genomic DNA Translation: AAB39284.1
AY557893 Genomic DNA Translation: AAS56219.1
BK006943 Genomic DNA Translation: DAA08845.1
PIRiC40535
RefSeqiNP_012592.1, NM_001181716.1

Genome annotation databases

EnsemblFungiiYJR058C; YJR058C; YJR058C
GeneIDi853521
KEGGisce:YJR058C

Similar proteinsi

Entry informationi

Entry nameiAP2S_YEAST
AccessioniPrimary (citable) accession number: Q00381
Secondary accession number(s): D6VWM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health