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Q00330

- RFBK_SALMU

UniProt

Q00330 - RFBK_SALMU

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Protein

Phosphomannomutase

Gene
manB, rfbK
Organism
Salmonella muenchen
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group C2 O antigen.

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111Phosphoserine intermediate By similarity
Metal bindingi111 – 1111Magnesium; via phosphate group By similarity
Metal bindingi245 – 2451Magnesium By similarity
Metal bindingi247 – 2471Magnesium By similarity
Metal bindingi249 – 2491Magnesium By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. O antigen biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.
UPA00281.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:manB
Synonyms:rfbK
OrganismiSalmonella muenchen
Taxonomic identifieri596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 4617Helical; Reviewed predictionAdd
BLAST
Transmembranei265 – 28420Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478PhosphomannomutasePRO_0000147825Add
BLAST

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ00330.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 1 hit.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00330-1 [UniParc]FASTAAdd to Basket

« Hide

MKNIYNTYDV INKSGINFGT SGARGLVTDF TPEVCARFTI SFLTVMQQRF    50
SFTTVALAID NRPSSYAMAQ ACAAALQEKG IKTVYYGVIP TPALAHQSIS 100
DKVPAIMVTG SHIPFDRNGL KFYRPDGEIT KDDENAIIHV DASFMQPKLE 150
QLTISTIAAR NYILRYTSLF PMPFLKNKRI GIYEHSSAGR DLYKTLFKML 200
GATVVSLARS DEFVPIDTEA VSEDDRNKAI TWAKKYQLDA IFSTDGDGDR 250
PLIADEYGNW LRGDILGLLC SLELAADAVA IPVSCNSTIS SGNFFKHVER 300
TKIGSPYVIA AFAKLSANYN CIAGFEANGG FLLGSDVYIN QRLLKALPTR 350
DALLPAIMLL FGSKDKSISE LVKKLPARYT YSNRLQDISV KTSMSLINLG 400
LTDQEDFLQY IGFNKHHILH SDVTDGFRIT IDNNNIIHLR PSGNAPELRC 450
YAEADSQEDA CNIVETVLSN IKSKLGRA 478
Length:478
Mass (Da):52,813
Last modified:October 1, 1994 - v1
Checksum:i982E5B885083B893
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61917 Genomic DNA. Translation: CAA43916.1.
PIRiS22622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61917 Genomic DNA. Translation: CAA43916.1 .
PIRi S22622.

3D structure databases

ProteinModelPortali Q00330.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .
UPA00281 .

Family and domain databases

Gene3Di 3.30.310.50. 1 hit.
3.40.120.10. 1 hit.
InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
[Graphical view ]
Pfami PF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view ]
SUPFAMi SSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEi PS00710. PGM_PMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis of the rfb gene cluster of Salmonella serovar muenchen (strain M67): the genetic basis of the polymorphism between groups C2 and B."
    Brown P.K., Romana L.K., Reeves P.R.
    Mol. Microbiol. 6:1385-1394(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M67.

Entry informationi

Entry nameiRFBK_SALMU
AccessioniPrimary (citable) accession number: Q00330
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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