Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q00310 (KRE2_CANAL)

Last modified June 16, 2009. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glycolipid 2-alpha-mannosyltransferase
    EC=2.4.1.131
Alternative name(s):
    Alpha-1,2-mannosyltransferase
Gene names
Name: KRE2
Synonyms: MNT1
ORF Names: CaO19.1665, CaO19.9234
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Required for the attachment of the third mannose residue of O-linked saccharides By similarity.

Catalytic activity

Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase 15 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Glycolipid 2-alpha-mannosyltransferase
PRO_0000208240

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 2819Signal-anchor for type II membrane protein Potential
Topological domain29 – 431403Lumenal Potential

Sites

Active site3181Nucleophile Potential

Sequences

Sequence LengthMass (Da)Tools
Q00310-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: E8AC1FAE9010B763

FASTA43150,004
        10         20         30         40         50         60 
MASTRSNARL IRFGIFALVL IGCGYILTRG SSFQPPNYQQ TQSPAAHEKQ TGNVAAGGGA 

        70         80         90        100        110        120 
GSGSAGAQVP LGKNRGPIPK AIMGAGEGGS DAPVPQQDIP DSYTLNDKIK ATFVTLARNS 

       130        140        150        160        170        180 
DLYSLAESIR HVEDRFNKKF HYDWVFLNDE EFNDEFKETV GSLVSGNTKF GLIPKEHWSY 

       190        200        210        220        230        240 
PPWIDQEKAA LVREQMREKK IIYGHSESYR HMCRFESGFF WRQEILNDYD YYWRVEPDIK 

       250        260        270        280        290        300 
LYCDIDYDIF KWMKDNNKDY AFTISLPEYK ETIPTLWDTT KEFIEKNPQY LAQNNLMDWV 

       310        320        330        340        350        360 
SDDKGQTYNG CHFWSNFEIG SLAFWRSEAY RKYFEHLDKA GGFFYERWGD APVHSIAAAL 

       370        380        390        400        410        420 
FLPREKIHFF EDVGYYHVPF TNCPVDKEVR KARNCNCDPN KDFTWRGYSC TTKYYTLNNF 

       430 
KRQKGWEKYT A 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of CaMnt1p, a mannosyl transferase important for adhesion and virulence of Candida albicans."
Buurman E.T., Westwater C., Hube B., Brown A.J., Odds F.C., Gow N.A.R.
Proc. Natl. Acad. Sci. U.S.A. 95:7670-7675(1998) [PubMed: 9636208] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CAI4.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314.

Cross-references

Sequence databases

X99619 Genomic DNA. Translation: CAA67930.1.
AACQ01000014 Genomic DNA. Translation: EAL02827.1.
AACQ01000013 Genomic DNA. Translation: EAL02954.1.
RefSeqXP_721623.1.
XP_721742.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

CAZyGT15. Glycosyltransferase Family 15.

Genome annotation databases

GeneID3636585.
3636767.

Organism-specific databases

CGDCAL0000071. MNT1.

Phylogenomic databases

OMAQ00310. NGCHFWS.

Enzyme and pathway databases

BRENDA2.4.1.131. 1124.

Family and domain databases

InterProIPR002685. Glyco_trans_15.
[Graphical view]
PfamPF01793. Glyco_transf_15. 1 hit.
[Graphical view]
PIRSFPIRSF018153. Glyco_trans_15. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKRE2_CANAL
AccessionPrimary (citable) accession number: Q00310
Secondary accession number(s): Q5AJC6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

Candida albicans

Candida albicans: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents