Reviewed, UniProtKB/Swiss-Prot Q00302 (MPPB_BLAEM)

Names and origin

Protein names

Recommended name:
    Mitochondrial-processing peptidase subunit beta
    EC=3.4.24.64
Alternative name(s):
    Beta-MPP
    BeMPP1

Gene names

Name:

MPP1

Organism

Blastocladiella emersonii (Aquatic fungus)

Taxonomic identifier

4808 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Blastocladiomycota › Blastocladiomycetes › Blastocladiales › Blastocladiaceae › Blastocladiella

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves presequences (transit peptides) from mitochondrial protein precursors.
Catalytic activity	Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
Cofactor	Divalent cations By similarity.
Subunit structure	Heterodimer of alpha and beta subunits By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the peptidase M16 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 465		Mitochondrial-processing peptidase subunit beta		PRO_0000026780
Sites
	Active site	82	1	Proton acceptor By similarity
	Metal binding	79	1	Zinc By similarity
	Metal binding	83	1	Zinc By similarity
	Metal binding	159	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q00302-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: CA38C439E1DA9AB2	FASTA	465	50,683
	10 20 30 40 50 60 MLSAALRLTA KRNVRSLATA SSSSYPGALL NVPKTQVTRL PNGLTVATES NPALATATVG 70 80 90 100 110 120 VWIDSGSRAE TKANNGVAHF LEHISFKGTK QRTQSGLEIE IENMGGHLNA YTSREQTVYY 130 140 150 160 170 180 AKLFSQDVAK GVNILGDILQ NSTLDPGAID RERAVILREA EEVDKQVEEV VFDHLHAAAF 190 200 210 220 230 240 PENALGYTIL GPKENIQTLS QADLQAYIKN NYTADRMVVV GAGNVDHAEL CKLAETNFGK 250 260 270 280 290 300 LPQGSGKAKF VRPAFTGSDV RIRVDDMPTA HIALAVEGAS WTSADHWPLL VASAMIGSYD 310 320 330 340 350 360 RAAGNAHPSS KLAQIVAKHN LANSFTSFNT TYSDTGLWGI YIQSNNRDNL DDLAHFTVRE 370 380 390 400 410 420 WMRLATAPSE GEVAIAKQQL KTSLLLALDG TTPVAEEIGR QMLAYGRRLS PFEIDRLVDA 430 440 450 460 VTVEDVKRVA NEFIYDRDLA IVAVGPVECL PDYNRIRSAM NLLRY

References

[1]	"Isolation, characterization, and expression of the gene encoding the beta subunit of the mitochondrial processing peptidase from Blastocladiella emersonii." Costa-Rocha C.R., Lopes-Gomes S. J. Bacteriol. 180:3967-3972(1998) [PubMed: 9683495] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U41300 Genomic DNA. Translation: AAC63093.1.
3D structure databases
HSSP	HSSP built from PDB template 1HR6 based on UniProtKB P10507.
ModBase	Search...
Protein family/group databases
MEROPS	M16.003. M16.980.
Enzyme and pathway databases
BRENDA	3.4.24.64. 2001.
Family and domain databases
InterPro	IPR011237. Pept_M16_core. IPR011765. Pept_M16_N. IPR007863. Peptidase_M16_C. [Graphical view]
Gene3D	G3DSA:3.30.830.10. Pept_M16_core. 2 hits.
Pfam	PF00675. Peptidase_M16. 1 hit. PF05193. Peptidase_M16_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPPB_BLAEM

Accession

Primary (citable) accession number: Q00302

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)