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Q00288 (PAX8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired box protein Pax-8
Gene names
Name:Pax8
Synonyms:Pax-8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.

Subunit structure

Interacts with WWTR1 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in the developing excretory system and the thyroid gland.

Sequence similarities

Contains 1 paired domain.

Ontologies

Keywords
   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainPaired box
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processS-shaped body morphogenesis

Inferred from expression pattern Ref.1. Source: UniProtKB

branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

cell differentiation

Inferred from mutant phenotype PubMed 9590297. Source: MGI

cellular response to gonadotropin stimulus

Inferred from electronic annotation. Source: Ensembl

central nervous system development

Inferred from expression pattern Ref.1. Source: UniProtKB

inner ear morphogenesis

Inferred from genetic interaction PubMed 20727173. Source: UniProtKB

kidney epithelium development

Inferred from expression pattern Ref.1. Source: UniProtKB

mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

mesonephric tubule development

Inferred from expression pattern Ref.1. Source: UniProtKB

mesonephros development

Inferred from mutant phenotype PubMed 12435636. Source: UniProtKB

metanephric S-shaped body morphogenesis

Inferred from electronic annotation. Source: Ensembl

metanephric comma-shaped body morphogenesis

Inferred from electronic annotation. Source: Ensembl

metanephric distal convoluted tubule development

Inferred from mutant phenotype PubMed 17314325. Source: UniProtKB

metanephric nephron tubule formation

Inferred from mutant phenotype PubMed 17314325. Source: UniProtKB

metanephros development

Inferred from expression pattern Ref.1. Source: UniProtKB

negative regulation of apoptotic process involved in metanephric collecting duct development

Inferred from mutant phenotype PubMed 17314325. Source: UniProtKB

negative regulation of apoptotic process involved in metanephric nephron tubule development

Inferred from mutant phenotype PubMed 17314325. Source: UniProtKB

negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

Inferred from mutant phenotype PubMed 17314325. Source: UniProtKB

negative regulation of mesenchymal cell apoptotic process involved in metanephros development

Inferred from mutant phenotype PubMed 17314325. Source: UniProtKB

organ morphogenesis

Traceable author statement PubMed 10197584. Source: MGI

otic vesicle development

Inferred from electronic annotation. Source: Ensembl

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from mutant phenotype PubMed 17314325. Source: UniProtKB

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from mutant phenotype PubMed 12435636. Source: UniProtKB

positive regulation of metanephric DCT cell differentiation

Inferred from mutant phenotype PubMed 17314325. Source: UniProtKB

positive regulation of thyroid hormone generation

Inferred from mutant phenotype PubMed 12586753. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence orthology PubMed 9214635. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12441357PubMed 17047028. Source: UniProtKB

pronephric field specification

Inferred from expression pattern PubMed 12435636. Source: UniProtKB

pronephros development

Inferred from mutant phenotype PubMed 12435636. Source: UniProtKB

regulation of apoptotic process

Inferred from mutant phenotype PubMed 12435636. Source: UniProtKB

regulation of metanephric nephron tubule epithelial cell differentiation

Inferred from mutant phenotype PubMed 17314325. Source: UniProtKB

regulation of thyroid-stimulating hormone secretion

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of transcription, DNA-templated

Traceable author statement PubMed 10197584. Source: MGI

thyroid gland development

Inferred from expression pattern Ref.1. Source: UniProtKB

transcription, DNA-templated

Inferred from direct assay PubMed 8413205. Source: UniProtKB

urogenital system development

Inferred from genetic interaction PubMed 12435636. Source: UniProtKB

   Cellular_componentnucleoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 19010321. Source: MGI

transcription factor complex

Traceable author statement PubMed 10197584. Source: MGI

   Molecular_functionDNA binding

Inferred from sequence or structural similarity PubMed 8861958. Source: UniProtKB

RNA polymerase II core promoter sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 12441357. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from direct assay PubMed 17047028. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Paired box protein Pax-8
PRO_0000050198

Regions

Domain9 – 135127Paired
Compositional bias316 – 32813Ser-rich

Experimental info

Sequence conflict3401G → D no nucleotide entry Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q00288 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: AAACD3EE54AA4488

FASTA45748,793
        10         20         30         40         50         60 
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK 

        70         80         90        100        110        120 
ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND 

       130        140        150        160        170        180 
TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY 

       190        200        210        220        230        240 
SINGLLGIAQ PGNDNKRKMD DSDQDSCRLS IDSQSSSSGP RKHLRTDTFS QHHLEALECP 

       250        260        270        280        290        300 
FERQHYPEAY ASPSHTKGEQ GLYPLPLLNS ALDDGKATLT SSNTPLGRNL STHQTYPVVA 

       310        320        330        340        350        360 
DPHSPFAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN AFPHAASVYG 

       370        380        390        400        410        420 
QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG MVAGSEYSGN AYSHTPYSSY 

       430        440        450 
SEAWRFPNSS LLSSPYYYSS TSRPSAPPTS ATAFDHL 

« Hide

References

« Hide 'large scale' references
[1]"Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland."
Plachov D., Chowdhury K., Walther C., Simon D., Guenet J.-L., Gruss P.
Development 110:643-651(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis."
Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M.
Genes Dev. 6:1589-1607(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 158; 263 AND 340.
[3]"The genomic organization of the murine Pax 8 gene and characterization of its basal promoter."
Okladnova O., Poleev A., Fantes J., Lee M., Plachov D., Horst J.
Genomics 42:452-461(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
Tissue: Kidney.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57487 mRNA. Translation: CAA40725.1.
X99592 expand/collapse EMBL AC list , X99593, X99594, X99595, X99596, X99597, X99598 Genomic DNA. Translation: CAA67904.1.
AL732528 Genomic DNA. Translation: CAM17808.1.
CH466542 Genomic DNA. Translation: EDL08172.1.
BC020526 mRNA. Translation: AAH20526.1.
CCDSCCDS15738.1.
PIRA56925.
RefSeqNP_035170.1. NM_011040.4.
UniGeneMm.2533.

3D structure databases

ProteinModelPortalQ00288.
SMRQ00288. Positions 1-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202035. 2 interactions.
IntActQ00288. 1 interaction.

PTM databases

PhosphoSiteQ00288.

Proteomic databases

PaxDbQ00288.
PRIDEQ00288.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028355; ENSMUSP00000028355; ENSMUSG00000026976.
GeneID18510.
KEGGmmu:18510.
UCSCuc008ipb.1. mouse.

Organism-specific databases

CTD7849.
MGIMGI:97492. Pax8.

Phylogenomic databases

eggNOGNOG326044.
GeneTreeENSGT00680000099910.
HOGENOMHOG000230938.
HOVERGENHBG009115.
InParanoidQ6GU20.
KOK09293.
OMADTFSQHH.
OrthoDBEOG7WT431.
TreeFamTF315397.

Gene expression databases

BgeeQ00288.
CleanExMM_PAX8.
GenevestigatorQ00288.

Family and domain databases

Gene3D1.10.10.10. 2 hits.
InterProIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00292. PAX. 1 hit.
PF12403. Pax2_C. 1 hit.
[Graphical view]
PRINTSPR00027. PAIREDBOX.
SMARTSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294244.
PROQ00288.
SOURCESearch...

Entry information

Entry namePAX8_MOUSE
AccessionPrimary (citable) accession number: Q00288
Secondary accession number(s): P97342, Q6GU20
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot