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Q00288

- PAX8_MOUSE

UniProt

Q00288 - PAX8_MOUSE

Protein

Paired box protein Pax-8

Gene

Pax8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. branching involved in ureteric bud morphogenesis Source: Ensembl
    2. cell differentiation Source: MGI
    3. cellular response to gonadotropin stimulus Source: Ensembl
    4. central nervous system development Source: UniProtKB
    5. inner ear morphogenesis Source: UniProtKB
    6. kidney epithelium development Source: UniProtKB
    7. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
    8. mesonephric tubule development Source: UniProtKB
    9. mesonephros development Source: UniProtKB
    10. metanephric comma-shaped body morphogenesis Source: Ensembl
    11. metanephric distal convoluted tubule development Source: UniProtKB
    12. metanephric nephron tubule formation Source: UniProtKB
    13. metanephric S-shaped body morphogenesis Source: Ensembl
    14. metanephros development Source: UniProtKB
    15. negative regulation of apoptotic process involved in metanephric collecting duct development Source: UniProtKB
    16. negative regulation of apoptotic process involved in metanephric nephron tubule development Source: UniProtKB
    17. negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Source: UniProtKB
    18. negative regulation of mesenchymal cell apoptotic process involved in metanephros development Source: UniProtKB
    19. organ morphogenesis Source: MGI
    20. otic vesicle development Source: Ensembl
    21. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    22. positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
    23. positive regulation of metanephric DCT cell differentiation Source: UniProtKB
    24. positive regulation of thyroid hormone generation Source: UniProtKB
    25. positive regulation of transcription, DNA-templated Source: UniProtKB
    26. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    27. pronephric field specification Source: UniProtKB
    28. pronephros development Source: UniProtKB
    29. regulation of apoptotic process Source: UniProtKB
    30. regulation of metanephric nephron tubule epithelial cell differentiation Source: UniProtKB
    31. regulation of thyroid-stimulating hormone secretion Source: UniProtKB
    32. regulation of transcription, DNA-templated Source: MGI
    33. S-shaped body morphogenesis Source: UniProtKB
    34. thyroid gland development Source: UniProtKB
    35. transcription, DNA-templated Source: UniProtKB
    36. urogenital system development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired box protein Pax-8
    Gene namesi
    Name:Pax8
    Synonyms:Pax-8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:97492. Pax8.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: UniProtKB
    2. nucleus Source: MGI
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Paired box protein Pax-8PRO_0000050198Add
    BLAST

    Proteomic databases

    PaxDbiQ00288.
    PRIDEiQ00288.

    PTM databases

    PhosphoSiteiQ00288.

    Expressioni

    Tissue specificityi

    Expressed in the developing excretory system and the thyroid gland.

    Gene expression databases

    BgeeiQ00288.
    CleanExiMM_PAX8.
    GenevestigatoriQ00288.

    Interactioni

    Subunit structurei

    Interacts with WWTR1.By similarity

    Protein-protein interaction databases

    BioGridi202035. 2 interactions.
    IntActiQ00288. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00288.
    SMRiQ00288. Positions 1-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 135127PairedPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi316 – 32813Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 paired domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Paired box

    Phylogenomic databases

    eggNOGiNOG326044.
    GeneTreeiENSGT00680000099910.
    HOGENOMiHOG000230938.
    HOVERGENiHBG009115.
    InParanoidiQ6GU20.
    KOiK09293.
    OMAiDTFSQHH.
    OrthoDBiEOG7WT431.
    TreeFamiTF315397.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    InterProiIPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR022130. Pax2_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00292. PAX. 1 hit.
    PF12403. Pax2_C. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SMARTiSM00351. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q00288-1 [UniParc]FASTAAdd to Basket

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    MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ    50
    LRVSHGCVSK ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP 100
    TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF NLPMDSCVAT 150
    KSLSPGHTLI PSSAVTPPES PQSDSLGSTY SINGLLGIAQ PGNDNKRKMD 200
    DSDQDSCRLS IDSQSSSSGP RKHLRTDTFS QHHLEALECP FERQHYPEAY 250
    ASPSHTKGEQ GLYPLPLLNS ALDDGKATLT SSNTPLGRNL STHQTYPVVA 300
    DPHSPFAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN 350
    AFPHAASVYG QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG 400
    MVAGSEYSGN AYSHTPYSSY SEAWRFPNSS LLSSPYYYSS TSRPSAPPTS 450
    ATAFDHL 457
    Length:457
    Mass (Da):48,793
    Last modified:July 27, 2011 - v3
    Checksum:iAAACD3EE54AA4488
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti340 – 3401G → D no nucleotide entry (PubMed:1516825)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57487 mRNA. Translation: CAA40725.1.
    X99592
    , X99593, X99594, X99595, X99596, X99597, X99598 Genomic DNA. Translation: CAA67904.1.
    AL732528 Genomic DNA. Translation: CAM17808.1.
    CH466542 Genomic DNA. Translation: EDL08172.1.
    BC020526 mRNA. Translation: AAH20526.1.
    CCDSiCCDS15738.1.
    PIRiA56925.
    RefSeqiNP_035170.1. NM_011040.4.
    UniGeneiMm.2533.

    Genome annotation databases

    EnsembliENSMUST00000028355; ENSMUSP00000028355; ENSMUSG00000026976.
    GeneIDi18510.
    KEGGimmu:18510.
    UCSCiuc008ipb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57487 mRNA. Translation: CAA40725.1 .
    X99592
    , X99593 , X99594 , X99595 , X99596 , X99597 , X99598 Genomic DNA. Translation: CAA67904.1 .
    AL732528 Genomic DNA. Translation: CAM17808.1 .
    CH466542 Genomic DNA. Translation: EDL08172.1 .
    BC020526 mRNA. Translation: AAH20526.1 .
    CCDSi CCDS15738.1.
    PIRi A56925.
    RefSeqi NP_035170.1. NM_011040.4.
    UniGenei Mm.2533.

    3D structure databases

    ProteinModelPortali Q00288.
    SMRi Q00288. Positions 1-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202035. 2 interactions.
    IntActi Q00288. 1 interaction.

    PTM databases

    PhosphoSitei Q00288.

    Proteomic databases

    PaxDbi Q00288.
    PRIDEi Q00288.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028355 ; ENSMUSP00000028355 ; ENSMUSG00000026976 .
    GeneIDi 18510.
    KEGGi mmu:18510.
    UCSCi uc008ipb.1. mouse.

    Organism-specific databases

    CTDi 7849.
    MGIi MGI:97492. Pax8.

    Phylogenomic databases

    eggNOGi NOG326044.
    GeneTreei ENSGT00680000099910.
    HOGENOMi HOG000230938.
    HOVERGENi HBG009115.
    InParanoidi Q6GU20.
    KOi K09293.
    OMAi DTFSQHH.
    OrthoDBi EOG7WT431.
    TreeFami TF315397.

    Miscellaneous databases

    NextBioi 294244.
    PROi Q00288.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q00288.
    CleanExi MM_PAX8.
    Genevestigatori Q00288.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    InterProi IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR022130. Pax2_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00292. PAX. 1 hit.
    PF12403. Pax2_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SMARTi SM00351. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland."
      Plachov D., Chowdhury K., Walther C., Simon D., Guenet J.-L., Gruss P.
      Development 110:643-651(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis."
      Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M.
      Genes Dev. 6:1589-1607(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 158; 263 AND 340.
    3. "The genomic organization of the murine Pax 8 gene and characterization of its basal promoter."
      Okladnova O., Poleev A., Fantes J., Lee M., Plachov D., Horst J.
      Genomics 42:452-461(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiPAX8_MOUSE
    AccessioniPrimary (citable) accession number: Q00288
    Secondary accession number(s): P97342, Q6GU20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3