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Protein

Paired box protein Pax-8

Gene

Pax8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. branching involved in ureteric bud morphogenesis Source: Ensembl
  2. cell differentiation Source: MGI
  3. cellular response to gonadotropin stimulus Source: MGI
  4. central nervous system development Source: UniProtKB
  5. inner ear morphogenesis Source: UniProtKB
  6. kidney epithelium development Source: UniProtKB
  7. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
  8. mesonephric tubule development Source: UniProtKB
  9. mesonephros development Source: UniProtKB
  10. metanephric comma-shaped body morphogenesis Source: Ensembl
  11. metanephric distal convoluted tubule development Source: UniProtKB
  12. metanephric nephron tubule formation Source: UniProtKB
  13. metanephric S-shaped body morphogenesis Source: Ensembl
  14. metanephros development Source: UniProtKB
  15. negative regulation of apoptotic process involved in metanephric collecting duct development Source: UniProtKB
  16. negative regulation of apoptotic process involved in metanephric nephron tubule development Source: UniProtKB
  17. negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Source: UniProtKB
  18. negative regulation of mesenchymal cell apoptotic process involved in metanephros development Source: UniProtKB
  19. organ morphogenesis Source: MGI
  20. otic vesicle development Source: Ensembl
  21. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  22. positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  23. positive regulation of metanephric DCT cell differentiation Source: UniProtKB
  24. positive regulation of thyroid hormone generation Source: UniProtKB
  25. positive regulation of transcription, DNA-templated Source: UniProtKB
  26. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  27. pronephric field specification Source: UniProtKB
  28. pronephros development Source: UniProtKB
  29. regulation of apoptotic process Source: UniProtKB
  30. regulation of metanephric nephron tubule epithelial cell differentiation Source: UniProtKB
  31. regulation of thyroid-stimulating hormone secretion Source: UniProtKB
  32. regulation of transcription, DNA-templated Source: MGI
  33. S-shaped body morphogenesis Source: UniProtKB
  34. thyroid gland development Source: UniProtKB
  35. transcription, DNA-templated Source: UniProtKB
  36. urogenital system development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-8
Gene namesi
Name:Pax8
Synonyms:Pax-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:97492. Pax8.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: UniProtKB
  2. nucleus Source: MGI
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Paired box protein Pax-8PRO_0000050198Add
BLAST

Proteomic databases

MaxQBiQ00288.
PaxDbiQ00288.
PRIDEiQ00288.

PTM databases

PhosphoSiteiQ00288.

Expressioni

Tissue specificityi

Expressed in the developing excretory system and the thyroid gland.

Gene expression databases

BgeeiQ00288.
CleanExiMM_PAX8.
ExpressionAtlasiQ00288. baseline and differential.
GenevestigatoriQ00288.

Interactioni

Subunit structurei

Interacts with WWTR1.By similarity

Protein-protein interaction databases

BioGridi202035. 2 interactions.
IntActiQ00288. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ00288.
SMRiQ00288. Positions 1-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 135127PairedPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi316 – 32813Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiNOG326044.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230938.
HOVERGENiHBG009115.
InParanoidiQ00288.
KOiK09293.
OMAiDTFSQHH.
OrthoDBiEOG7WT431.
TreeFamiTF315397.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
PF12403. Pax2_C. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ
60 70 80 90 100
LRVSHGCVSK ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP
110 120 130 140 150
TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF NLPMDSCVAT
160 170 180 190 200
KSLSPGHTLI PSSAVTPPES PQSDSLGSTY SINGLLGIAQ PGNDNKRKMD
210 220 230 240 250
DSDQDSCRLS IDSQSSSSGP RKHLRTDTFS QHHLEALECP FERQHYPEAY
260 270 280 290 300
ASPSHTKGEQ GLYPLPLLNS ALDDGKATLT SSNTPLGRNL STHQTYPVVA
310 320 330 340 350
DPHSPFAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN
360 370 380 390 400
AFPHAASVYG QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG
410 420 430 440 450
MVAGSEYSGN AYSHTPYSSY SEAWRFPNSS LLSSPYYYSS TSRPSAPPTS

ATAFDHL
Length:457
Mass (Da):48,793
Last modified:July 27, 2011 - v3
Checksum:iAAACD3EE54AA4488
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401G → D no nucleotide entry (PubMed:1516825).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57487 mRNA. Translation: CAA40725.1.
X99592
, X99593, X99594, X99595, X99596, X99597, X99598 Genomic DNA. Translation: CAA67904.1.
AL732528 Genomic DNA. Translation: CAM17808.1.
CH466542 Genomic DNA. Translation: EDL08172.1.
BC020526 mRNA. Translation: AAH20526.1.
CCDSiCCDS15738.1.
PIRiA56925.
RefSeqiNP_035170.1. NM_011040.4.
UniGeneiMm.2533.

Genome annotation databases

EnsembliENSMUST00000028355; ENSMUSP00000028355; ENSMUSG00000026976.
GeneIDi18510.
KEGGimmu:18510.
UCSCiuc008ipb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57487 mRNA. Translation: CAA40725.1.
X99592
, X99593, X99594, X99595, X99596, X99597, X99598 Genomic DNA. Translation: CAA67904.1.
AL732528 Genomic DNA. Translation: CAM17808.1.
CH466542 Genomic DNA. Translation: EDL08172.1.
BC020526 mRNA. Translation: AAH20526.1.
CCDSiCCDS15738.1.
PIRiA56925.
RefSeqiNP_035170.1. NM_011040.4.
UniGeneiMm.2533.

3D structure databases

ProteinModelPortaliQ00288.
SMRiQ00288. Positions 1-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202035. 2 interactions.
IntActiQ00288. 1 interaction.

PTM databases

PhosphoSiteiQ00288.

Proteomic databases

MaxQBiQ00288.
PaxDbiQ00288.
PRIDEiQ00288.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028355; ENSMUSP00000028355; ENSMUSG00000026976.
GeneIDi18510.
KEGGimmu:18510.
UCSCiuc008ipb.1. mouse.

Organism-specific databases

CTDi7849.
MGIiMGI:97492. Pax8.

Phylogenomic databases

eggNOGiNOG326044.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230938.
HOVERGENiHBG009115.
InParanoidiQ00288.
KOiK09293.
OMAiDTFSQHH.
OrthoDBiEOG7WT431.
TreeFamiTF315397.

Miscellaneous databases

NextBioi294244.
PROiQ00288.
SOURCEiSearch...

Gene expression databases

BgeeiQ00288.
CleanExiMM_PAX8.
ExpressionAtlasiQ00288. baseline and differential.
GenevestigatoriQ00288.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
PF12403. Pax2_C. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland."
    Plachov D., Chowdhury K., Walther C., Simon D., Guenet J.-L., Gruss P.
    Development 110:643-651(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis."
    Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M.
    Genes Dev. 6:1589-1607(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 158; 263 AND 340.
  3. "The genomic organization of the murine Pax 8 gene and characterization of its basal promoter."
    Okladnova O., Poleev A., Fantes J., Lee M., Plachov D., Horst J.
    Genomics 42:452-461(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiPAX8_MOUSE
AccessioniPrimary (citable) accession number: Q00288
Secondary accession number(s): P97342, Q6GU20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.