Reviewed, UniProtKB/Swiss-Prot Q00277 (GPX1_SCHMA)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase
      Short name=GPX
    EC=1.11.1.9

Gene names

Name:

GPX1

Organism

Schistosoma mansoni (Blood fluke)

Taxonomic identifier

6183 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Induction	Activity increases significantly as worms mature in their host and is positively correlated to the resistance to antioxidants.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Coding sequence diversity	Selenocysteine
Ligand	Selenium
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 169	169	Glutathione peroxidase		PRO_0000066645
Sites
	Active site	43	1	By similarity
Amino acid modifications
	Non-standard residue	43	1	Selenocysteine

Sequences

	Sequence		Length	Mass (Da)
	Q00277-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 4B787788913F84B0	FASTA	169	19,471
	10 20 30 40 50 60 MSSSHKSWNS IYEFTVKDIN GVDVSLEKYR GHVCLIVNVA CKUGATDKNY RQLQEMHTRL 70 80 90 100 110 120 VGKGLRILAF PCNQFGGQEP WAEAEIKKFV TEKYGVQFDM FSKIKVNGSD ADDLYKFLKS 130 140 150 160 RQHGTLTNNI KWNFSKFLVD RQGQPVKRYS PTTAPYDIEG DIMELLEKK

References

[1]	"Molecular cloning and sequencing of glutathione peroxidase from Schistosoma mansoni." Williams D.L., Pierce R.J., Cookson E., Capron A. Mol. Biochem. Parasitol. 52:127-130(1992) [PubMed: 1625700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Puerto Rican.
[2]	Williams D.L., Pierce R.J., Cookson E., Capron A. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 43.
[3]	"Schistosoma mansoni: cloning the gene encoding glutathione peroxidase." Mei H., Loverde P.T. Exp. Parasitol. 80:319-322(1995) [PubMed: 7895842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NMRI.
[4]	"Cloning and characterization of the gene encoding Schistosoma mansoni glutathione peroxidase." Roche C., Williams D.L., Khalife J., Lepresle T., Capron A., Pierce R.J. Gene 138:149-152(1994) [PubMed: 8125294] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Puerto Rican.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M86510 mRNA. Translation: AAA29885.2. L37762 Genomic DNA. Translation: AAC14468.2. L14328 Genomic DNA. Translation: AAB08485.2.
3D structure databases
HSSP	HSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBase	Search...
Protein family/group databases
PeroxiBase	3745. SmamGPx01.
Family and domain databases
InterPro	IPR000889. Glut_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX1_SCHMA

Accession

Primary (citable) accession number: Q00277

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	February 26, 2008
Last modified:	November 25, 2008
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)