Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syntaxin-2

Gene

Stx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.2 Publications

GO - Molecular functioni

  • calcium-dependent protein binding Source: HGNC
  • protein dimerization activity Source: MGI

GO - Biological processi

  • acrosome reaction Source: HGNC
  • cell differentiation Source: MGI
  • cornified envelope assembly Source: MGI
  • embryo implantation Source: MGI
  • intracellular protein transport Source: InterPro
  • membrane fusion Source: GOC
  • protein oligomerization Source: MGI
  • regulation of blood coagulation Source: MGI
  • response to hydroperoxide Source: MGI
  • vesicle-mediated transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-2
Alternative name(s):
Epimorphin
Gene namesi
Name:Stx2
Synonyms:Epim
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108059. Stx2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 265265CytoplasmicSequence analysisAdd
BLAST
Transmembranei266 – 28924Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: MGI
  • cell-cell junction Source: MGI
  • cell surface Source: MGI
  • cytoplasmic vesicle Source: MGI
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • lamellipodium Source: MGI
  • membrane raft Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Syntaxin-2PRO_0000210197Add
BLAST

Proteomic databases

EPDiQ00262.
MaxQBiQ00262.
PaxDbiQ00262.
PRIDEiQ00262.

PTM databases

PhosphoSiteiQ00262.

Expressioni

Gene expression databases

CleanExiMM_STX2.

Interactioni

Subunit structurei

Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: HGNC
  • protein dimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031378.

Structurei

3D structure databases

ProteinModelPortaliQ00262.
SMRiQ00262. Positions 27-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 25463t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili68 – 10134Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ00262.
PhylomeDBiQ00262.

Family and domain databases

InterProiIPR028671. STX2.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF36. PTHR19957:SF36. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDRLPDLTA CRTNDDGDTA VVIVEKDHFM DGFFHQVEEI RSSIARIAQH
60 70 80 90 100
VEDVKKNHSI ILSAPNPEGK IKEELEDLDK EIKKTANRIR GKLKSIEQSC
110 120 130 140 150
DQDENGNRTS VDLRIRRTQH SVLSRKFVDV MTEYNEAQIL FRERSKGRIQ
160 170 180 190 200
RQLEITGRTT TDDELEEMLE SGKPSIFISD IISDSQITRQ ALNEIESRHK
210 220 230 240 250
DIMKLETSIR ELHEMFMDMA MFVETQGEMV NNIERNVVNS VDYVEHAKEE
260 270 280
TKKAIKYQSK ARRKKWIIAA VAVAVIAVLA LIIGLSVGK
Length:289
Mass (Da):33,178
Last modified:December 1, 1992 - v1
Checksum:i9D82330D0F5CA2F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10475 mRNA. Translation: BAA01278.1.
CCDSiCCDS19692.1.
PIRiA38216. S51193.
UniGeneiMm.260716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10475 mRNA. Translation: BAA01278.1.
CCDSiCCDS19692.1.
PIRiA38216. S51193.
UniGeneiMm.260716.

3D structure databases

ProteinModelPortaliQ00262.
SMRiQ00262. Positions 27-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031378.

PTM databases

PhosphoSiteiQ00262.

Proteomic databases

EPDiQ00262.
MaxQBiQ00262.
PaxDbiQ00262.
PRIDEiQ00262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108059. Stx2.

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ00262.
PhylomeDBiQ00262.

Miscellaneous databases

ChiTaRSiStx2. mouse.
PROiQ00262.
SOURCEiSearch...

Gene expression databases

CleanExiMM_STX2.

Family and domain databases

InterProiIPR028671. STX2.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF36. PTHR19957:SF36. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Epimorphin: a mesenchymal protein essential for epithelial morphogenesis."
    Hirai Y., Takebe K., Takashina M., Kobayashi S., Takeichi M.
    Cell 69:471-481(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sodium-dodecyl-sulfate-resistant complex formation of epimorphin monomers and interaction of the 150-kDa complex with the cell surface."
    Hirai Y.
    Eur. J. Biochem. 225:1133-1139(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction."
    Hutt D.M., Baltz J.M., Ngsee J.K.
    J. Biol. Chem. 280:20197-20203(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SYT6 AND SYT8.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Lung and Testis.

Entry informationi

Entry nameiSTX2_MOUSE
AccessioniPrimary (citable) accession number: Q00262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.