Q00262 (STX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syntaxin-2

Alternative name(s):
Epimorphin

Gene names

Name:	Stx2
Synonyms:	Epim

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm. Ref.2 Ref.3
Subunit structure	Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent. Ref.3
Subcellular location	Membrane; Single-pass type IV membrane protein.
Sequence similarities	Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acrosome reaction Inferred from direct assay Ref.3. Source: HGNC cell differentiation Inferred from direct assay PubMed 15685636. Source: MGI embryo implantation Inferred by curator PubMed 15685636. Source: MGI intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular_component	cell surface Inferred from direct assay PubMed 11702001. Source: MGI cell-cell junction Inferred from direct assay PubMed 11702001. Source: MGI cytoplasmic vesicle Inferred from direct assay PubMed 18321981. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane raft Inferred from direct assay PubMed 11784086. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Syntaxin-2		PRO_0000210197
Regions
	Topological domain	1 – 265	265	Cytoplasmic Potential
	Transmembrane	266 – 289	24	Helical; Anchor for type IV membrane protein; Potential
	Domain	192 – 254	63	t-SNARE coiled-coil homology
	Coiled coil	68 – 101	34	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q00262 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 9D82330D0F5CA2F4	FASTA	289	33,178
	10 20 30 40 50 60 MRDRLPDLTA CRTNDDGDTA VVIVEKDHFM DGFFHQVEEI RSSIARIAQH VEDVKKNHSI 70 80 90 100 110 120 ILSAPNPEGK IKEELEDLDK EIKKTANRIR GKLKSIEQSC DQDENGNRTS VDLRIRRTQH 130 140 150 160 170 180 SVLSRKFVDV MTEYNEAQIL FRERSKGRIQ RQLEITGRTT TDDELEEMLE SGKPSIFISD 190 200 210 220 230 240 IISDSQITRQ ALNEIESRHK DIMKLETSIR ELHEMFMDMA MFVETQGEMV NNIERNVVNS 250 260 270 280 VDYVEHAKEE TKKAIKYQSK ARRKKWIIAA VAVAVIAVLA LIIGLSVGK

References

[1]	"Epimorphin: a mesenchymal protein essential for epithelial morphogenesis." Hirai Y., Takebe K., Takashina M., Kobayashi S., Takeichi M. Cell 69:471-481(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sodium-dodecyl-sulfate-resistant complex formation of epimorphin monomers and interaction of the 150-kDa complex with the cell surface." Hirai Y. Eur. J. Biochem. 225:1133-1139(1994) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[3]	"Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction." Hutt D.M., Baltz J.M., Ngsee J.K. J. Biol. Chem. 280:20197-20203(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SYT6 AND SYT8.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D10475 mRNA. Translation: BAA01278.1.
IPI	IPI00117112.
PIR	S51193. A38216.
UniGene	Mm.260716.
3D structure databases
ProteinModelPortal	Q00262.
SMR	Q00262. Positions 27-150, 189-284.
ModBase	Search...
PTM databases
PhosphoSite	Q00262.
Proteomic databases
PaxDb	Q00262.
PRIDE	Q00262.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:108059. Stx2.
Phylogenomic databases
eggNOG	COG5074.
HOGENOM	HOG000286023.
HOVERGEN	HBG000497.
InParanoid	Q00262.
OrthoDB	EOG4ZPDW5.
Gene expression databases
CleanEx	MM_STX2.
Genevestigator	Q00262.
GermOnline	ENSMUSG00000029428. Mus musculus.
Family and domain databases
InterPro	IPR006012. Syntaxin/epimorphin_CS. IPR006011. Syntaxin_N. IPR010989. t-SNARE. IPR000727. T_SNARE_dom. [Graphical view]
Pfam	PF05739. SNARE. 1 hit. PF00804. Syntaxin. 1 hit. [Graphical view]
SMART	SM00503. SynN. 1 hit. SM00397. t_SNARE. 1 hit. [Graphical view]
SUPFAM	SSF47661. t-snare. 1 hit.
PROSITE	PS00914. SYNTAXIN. 1 hit. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	STX2. mouse.
SOURCE	Search...

Entry information

Entry name

STX2_MOUSE

Accession

Primary (citable) accession number: Q00262

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program