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Protein

GTP-binding protein RHO3

Gene

RHO3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in cell growth. Required to keep the uninucleated state. May be involved in the organization of the cytoskeleton which affects microtubule functions. Most likely RHO3 and RHO4 of S.cerevisiae regulate partially overlapping but different pathways.1 Publication

Miscellaneous

Present with 5910 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 30GTPBy similarity8
Nucleotide bindingi70 – 74GTPBy similarity5
Nucleotide bindingi128 – 131GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: SGD

GO - Biological processi

  • establishment or maintenance of actin cytoskeleton polarity Source: SGD
  • positive regulation of exocytosis Source: SGD
  • positive regulation of formin-nucleated actin cable assembly Source: SGD
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31371-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein RHO3
Gene namesi
Name:RHO3
Ordered Locus Names:YIL118W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL118W
SGDiS000001380 RHO3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989471 – 228GTP-binding protein RHO3Add BLAST228
PropeptideiPRO_0000281277229 – 231Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei228Cysteine methyl esterBy similarity1
Lipidationi228S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ00245
PaxDbiQ00245
PRIDEiQ00245

PTM databases

SwissPalmiQ00245

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EXO70P196584EBI-15138,EBI-6717

Protein-protein interaction databases

BioGridi34873, 234 interactors
DIPiDIP-4820N
IntActiQ00245, 3 interactors
MINTiQ00245
STRINGi4932.YIL118W

Structurei

3D structure databases

ProteinModelPortaliQ00245
SMRiQ00245
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 53Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000144594
HOGENOMiHOG000233974
InParanoidiQ00245
KOiK07975
OMAiYFPTVYE
OrthoDBiEOG092C4TDG

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLCGSAST SNKPIERKIV ILGDGACGKT SLLNVFTRGY FPEVYEPTVF
60 70 80 90 100
ENYIHDIFVD SKHITLSLWD TAGQEEFDRL RSLSYSDTQC IMLCFSIDSR
110 120 130 140 150
DSLENVQNKW VGEITDHCEG VKLVLVALKC DLRNNENESN AITPNNIQQD
160 170 180 190 200
NSVSNDNGNN INSTSNGKNL ISYEEGLAMA KKIGALRYLE CSAKLNKGVN
210 220 230
EAFTEAARVA LTAGPVATEV KSDSGSSCTI M
Length:231
Mass (Da):25,312
Last modified:February 1, 1995 - v2
Checksum:i7C8BEB15502AD024
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129K → E in BAA00897 (PubMed:1587484).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10006 Genomic DNA Translation: BAA00897.1
Z46833 Genomic DNA Translation: CAA86874.1
AY557857 Genomic DNA Translation: AAS56183.1
BK006942 Genomic DNA Translation: DAA08435.1
PIRiS49891
RefSeqiNP_012148.1, NM_001179466.1

Genome annotation databases

EnsemblFungiiYIL118W; YIL118W; YIL118W
GeneIDi854688
KEGGisce:YIL118W

Similar proteinsi

Entry informationi

Entry nameiRHO3_YEAST
AccessioniPrimary (citable) accession number: Q00245
Secondary accession number(s): D6VVG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

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