Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q00238

- ICAM1_RAT

UniProt

Q00238 - ICAM1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Intercellular adhesion molecule 1

Gene

Icam1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).By similarity

GO - Molecular functioni

  1. integrin binding Source: RGD
  2. protein complex binding Source: RGD

GO - Biological processi

  1. acute inflammatory response to antigenic stimulus Source: RGD
  2. cell adhesion mediated by integrin Source: Ensembl
  3. cell aging Source: RGD
  4. cellular response to alkaloid Source: RGD
  5. cellular response to glucose stimulus Source: RGD
  6. cellular response to hypoxia Source: RGD
  7. cellular response to interleukin-1 Source: RGD
  8. cellular response to lipopolysaccharide Source: RGD
  9. cellular response to nutrient levels Source: RGD
  10. cellular response to organic substance Source: RGD
  11. cellular response to tumor necrosis factor Source: RGD
  12. establishment of endothelial barrier Source: Ensembl
  13. establishment of Sertoli cell barrier Source: RGD
  14. leukocyte cell-cell adhesion Source: Ensembl
  15. leukocyte migration Source: RGD
  16. membrane to membrane docking Source: Ensembl
  17. negative regulation of calcium ion transport Source: RGD
  18. negative regulation of endothelial cell apoptotic process Source: Ensembl
  19. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  20. ovarian follicle development Source: RGD
  21. positive regulation of actin filament polymerization Source: RGD
  22. positive regulation of cellular extravasation Source: Ensembl
  23. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  24. positive regulation of NF-kappaB transcription factor activity Source: RGD
  25. positive regulation of nitric oxide biosynthetic process Source: RGD
  26. positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
  27. positive regulation of Rho GTPase activity Source: RGD
  28. positive regulation of vasoconstriction Source: RGD
  29. receptor-mediated virion attachment to host cell Source: Ensembl
  30. regulation of cell adhesion Source: Ensembl
  31. regulation of cell shape Source: RGD
  32. regulation of ruffle assembly Source: Ensembl
  33. response to amino acid Source: RGD
  34. response to amphetamine Source: RGD
  35. response to copper ion Source: RGD
  36. response to drug Source: RGD
  37. response to ethanol Source: RGD
  38. response to gonadotropin Source: RGD
  39. response to hypoxia Source: RGD
  40. response to ionizing radiation Source: RGD
  41. response to lipopolysaccharide Source: RGD
  42. response to organic cyclic compound Source: RGD
  43. response to sulfur dioxide Source: RGD
  44. sensory perception of sound Source: RGD
  45. single organismal cell-cell adhesion Source: RGD
  46. T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: Ensembl
  47. T cell antigen processing and presentation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 1
Short name:
ICAM-1
Alternative name(s):
CD_antigen: CD54
Gene namesi
Name:Icam1
Synonyms:Icam-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi2857. Icam1.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: RGD
  2. external side of plasma membrane Source: Ensembl
  3. extracellular space Source: RGD
  4. extracellular vesicular exosome Source: Ensembl
  5. immunological synapse Source: Ensembl
  6. integral component of membrane Source: UniProtKB-KW
  7. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727By similarityAdd
BLAST
Chaini28 – 545518Intercellular adhesion molecule 1PRO_0000014788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi48 ↔ 92PROSITE-ProRule annotation
Disulfide bondi52 ↔ 96PROSITE-ProRule annotation
Disulfide bondi135 ↔ 186PROSITE-ProRule annotation
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi237 ↔ 290PROSITE-ProRule annotation
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi332 ↔ 382PROSITE-ProRule annotation
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi430 ↔ 469PROSITE-ProRule annotation
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ00238.
PRIDEiQ00238.

PTM databases

PhosphoSiteiQ00238.

Expressioni

Gene expression databases

GenevestigatoriQ00238.

Interactioni

Subunit structurei

Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4997073.
STRINGi10116.ENSRNOP00000028066.

Structurei

3D structure databases

ProteinModelPortaliQ00238.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 492465ExtracellularSequence AnalysisAdd
BLAST
Topological domaini518 – 54528CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei493 – 51725HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 10363Ig-like C2-type 1Add
BLAST
Domaini128 – 19366Ig-like C2-type 2Add
BLAST
Domaini230 – 29768Ig-like C2-type 3Add
BLAST
Domaini325 – 38965Ig-like C2-type 4Add
BLAST
Domaini423 – 47654Ig-like C2-type 5Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi177 – 1793Cell attachment siteSequence Analysis

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146347.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000059554.
HOVERGENiHBG052074.
InParanoidiQ00238.
KOiK06490.
OMAiRDCPGNW.
OrthoDBiEOG7QG43X.
PhylomeDBiQ00238.
TreeFamiTF333745.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00238-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASTRARPML PLLLVLVAVV IPGPVGAQVS IHPTEAFLPR GGSVQVNCSS
60 70 80 90 100
SCEDENLGLG LETNWMKDEL SSGHNWKLFK LSDIGEDSRP LCFENCGTTQ
110 120 130 140 150
SSASATITVY SFPERVELDP LPAWQQVGKN LILRCLVEGG APRTQLSVVL
160 170 180 190 200
LRGNETLSRQ AVDGDPKEIT FTVLASRGDH GANFSCFTEL DLRPQGLSLF
210 220 230 240 250
KNVSEVRQLR TFDLPTRVLK LDTPDLLEVG TQQKFLCSLE GLFPASEAQI
260 270 280 290 300
YLEMGGQMLT LESTNSRDFV SATASVEVTE KLDRTLQLRC VLELADQTLE
310 320 330 340 350
MEKTLRIYNF SAPILTLSQP EVSEGDQVTV KCEAHGGAQV VLLNSTSPRP
360 370 380 390 400
PTSQGTSPRP PTSQIQFTLN ASPEDHKRRF FCSAALEVDG KSLFKNQTLE
410 420 430 440 450
LHVLYGPHLD KKDCLGNWTW QEGSQQTLTC QPQGNPAPNL TCSRKADGVP
460 470 480 490 500
LPIGMVKSVK REMNGTYKCR AFSSRGSITR DVHLTVLYHD QNTWVIIVGV
510 520 530 540
LVLIIAGFVI VASIYTYYRQ RKIRIYKLQK AQEEALKLKV QAPPP
Length:545
Mass (Da):60,142
Last modified:December 1, 1992 - v1
Checksum:i30F4546FA4D0CFF4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00913 mRNA. Translation: BAA00759.1.
BC081837 mRNA. Translation: AAH81837.1.
PIRiS21765. JU0341.
RefSeqiNP_037099.1. NM_012967.1.
UniGeneiRn.12.

Genome annotation databases

EnsembliENSRNOT00000028066; ENSRNOP00000028066; ENSRNOG00000020679.
GeneIDi25464.
KEGGirno:25464.
UCSCiRGD:2857. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00913 mRNA. Translation: BAA00759.1 .
BC081837 mRNA. Translation: AAH81837.1 .
PIRi S21765. JU0341.
RefSeqi NP_037099.1. NM_012967.1.
UniGenei Rn.12.

3D structure databases

ProteinModelPortali Q00238.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4997073.
STRINGi 10116.ENSRNOP00000028066.

PTM databases

PhosphoSitei Q00238.

Proteomic databases

PaxDbi Q00238.
PRIDEi Q00238.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028066 ; ENSRNOP00000028066 ; ENSRNOG00000020679 .
GeneIDi 25464.
KEGGi rno:25464.
UCSCi RGD:2857. rat.

Organism-specific databases

CTDi 3383.
RGDi 2857. Icam1.

Phylogenomic databases

eggNOGi NOG146347.
GeneTreei ENSGT00530000063246.
HOGENOMi HOG000059554.
HOVERGENi HBG052074.
InParanoidi Q00238.
KOi K06490.
OMAi RDCPGNW.
OrthoDBi EOG7QG43X.
PhylomeDBi Q00238.
TreeFami TF333745.

Miscellaneous databases

NextBioi 606747.
PROi Q00238.

Gene expression databases

Genevestigatori Q00238.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
Pfami PF03921. ICAM_N. 1 hit.
[Graphical view ]
PRINTSi PR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiICAM1_RAT
AccessioniPrimary (citable) accession number: Q00238
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3