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Q00238

- ICAM1_RAT

UniProt

Q00238 - ICAM1_RAT

Protein

Intercellular adhesion molecule 1

Gene

Icam1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation By similarity.By similarity

    GO - Molecular functioni

    1. integrin binding Source: RGD
    2. protein complex binding Source: RGD

    GO - Biological processi

    1. acute inflammatory response to antigenic stimulus Source: RGD
    2. cell adhesion mediated by integrin Source: Ensembl
    3. cell aging Source: RGD
    4. cellular response to alkaloid Source: RGD
    5. cellular response to glucose stimulus Source: RGD
    6. cellular response to hypoxia Source: RGD
    7. cellular response to interleukin-1 Source: RGD
    8. cellular response to lipopolysaccharide Source: RGD
    9. cellular response to nutrient levels Source: RGD
    10. cellular response to organic substance Source: RGD
    11. cellular response to tumor necrosis factor Source: RGD
    12. establishment of Sertoli cell barrier Source: RGD
    13. leukocyte cell-cell adhesion Source: Ensembl
    14. leukocyte migration Source: RGD
    15. membrane to membrane docking Source: Ensembl
    16. negative regulation of calcium ion transport Source: RGD
    17. ovarian follicle development Source: RGD
    18. positive regulation of actin filament polymerization Source: RGD
    19. positive regulation of cellular extravasation Source: Ensembl
    20. positive regulation of NF-kappaB transcription factor activity Source: RGD
    21. positive regulation of nitric oxide biosynthetic process Source: RGD
    22. positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
    23. positive regulation of Rho GTPase activity Source: RGD
    24. positive regulation of vasoconstriction Source: RGD
    25. receptor-mediated virion attachment to host cell Source: Ensembl
    26. regulation of cell adhesion Source: Ensembl
    27. regulation of cell shape Source: RGD
    28. response to amino acid Source: RGD
    29. response to amphetamine Source: RGD
    30. response to copper ion Source: RGD
    31. response to drug Source: RGD
    32. response to ethanol Source: RGD
    33. response to gonadotropin Source: RGD
    34. response to hypoxia Source: RGD
    35. response to ionizing radiation Source: RGD
    36. response to lipopolysaccharide Source: RGD
    37. response to organic cyclic compound Source: RGD
    38. response to sulfur dioxide Source: RGD
    39. sensory perception of sound Source: RGD
    40. single organismal cell-cell adhesion Source: RGD
    41. T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: Ensembl
    42. T cell antigen processing and presentation Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intercellular adhesion molecule 1
    Short name:
    ICAM-1
    Alternative name(s):
    CD_antigen: CD54
    Gene namesi
    Name:Icam1
    Synonyms:Icam-1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi2857. Icam1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: RGD
    2. external side of plasma membrane Source: Ensembl
    3. extracellular space Source: RGD
    4. immunological synapse Source: Ensembl
    5. integral component of membrane Source: UniProtKB-KW
    6. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727By similarityAdd
    BLAST
    Chaini28 – 545518Intercellular adhesion molecule 1PRO_0000014788Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi48 ↔ 92PROSITE-ProRule annotation
    Disulfide bondi52 ↔ 96PROSITE-ProRule annotation
    Disulfide bondi135 ↔ 186PROSITE-ProRule annotation
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi237 ↔ 290PROSITE-ProRule annotation
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi332 ↔ 382PROSITE-ProRule annotation
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi430 ↔ 469PROSITE-ProRule annotation
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ00238.
    PRIDEiQ00238.

    PTM databases

    PhosphoSiteiQ00238.

    Expressioni

    Gene expression databases

    GenevestigatoriQ00238.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF By similarity.By similarity

    Protein-protein interaction databases

    MINTiMINT-4997073.
    STRINGi10116.ENSRNOP00000028066.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00238.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 492465ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini518 – 54528CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei493 – 51725HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 10363Ig-like C2-type 1Add
    BLAST
    Domaini128 – 19366Ig-like C2-type 2Add
    BLAST
    Domaini230 – 29768Ig-like C2-type 3Add
    BLAST
    Domaini325 – 38965Ig-like C2-type 4Add
    BLAST
    Domaini423 – 47654Ig-like C2-type 5Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi177 – 1793Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. ICAM family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146347.
    GeneTreeiENSGT00530000063246.
    HOGENOMiHOG000059554.
    HOVERGENiHBG052074.
    InParanoidiQ00238.
    KOiK06490.
    OMAiRDCPGNW.
    OrthoDBiEOG7QG43X.
    PhylomeDBiQ00238.
    TreeFamiTF333745.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR003988. ICAM.
    IPR013768. ICAM_N.
    IPR003987. ICAM_VCAM_N.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    PfamiPF03921. ICAM_N. 1 hit.
    [Graphical view]
    PRINTSiPR01473. ICAM.
    PR01472. ICAMVCAM1.
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q00238-1 [UniParc]FASTAAdd to Basket

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    MASTRARPML PLLLVLVAVV IPGPVGAQVS IHPTEAFLPR GGSVQVNCSS    50
    SCEDENLGLG LETNWMKDEL SSGHNWKLFK LSDIGEDSRP LCFENCGTTQ 100
    SSASATITVY SFPERVELDP LPAWQQVGKN LILRCLVEGG APRTQLSVVL 150
    LRGNETLSRQ AVDGDPKEIT FTVLASRGDH GANFSCFTEL DLRPQGLSLF 200
    KNVSEVRQLR TFDLPTRVLK LDTPDLLEVG TQQKFLCSLE GLFPASEAQI 250
    YLEMGGQMLT LESTNSRDFV SATASVEVTE KLDRTLQLRC VLELADQTLE 300
    MEKTLRIYNF SAPILTLSQP EVSEGDQVTV KCEAHGGAQV VLLNSTSPRP 350
    PTSQGTSPRP PTSQIQFTLN ASPEDHKRRF FCSAALEVDG KSLFKNQTLE 400
    LHVLYGPHLD KKDCLGNWTW QEGSQQTLTC QPQGNPAPNL TCSRKADGVP 450
    LPIGMVKSVK REMNGTYKCR AFSSRGSITR DVHLTVLYHD QNTWVIIVGV 500
    LVLIIAGFVI VASIYTYYRQ RKIRIYKLQK AQEEALKLKV QAPPP 545
    Length:545
    Mass (Da):60,142
    Last modified:December 1, 1992 - v1
    Checksum:i30F4546FA4D0CFF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00913 mRNA. Translation: BAA00759.1.
    BC081837 mRNA. Translation: AAH81837.1.
    PIRiS21765. JU0341.
    RefSeqiNP_037099.1. NM_012967.1.
    UniGeneiRn.12.

    Genome annotation databases

    EnsembliENSRNOT00000028066; ENSRNOP00000028066; ENSRNOG00000020679.
    GeneIDi25464.
    KEGGirno:25464.
    UCSCiRGD:2857. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00913 mRNA. Translation: BAA00759.1 .
    BC081837 mRNA. Translation: AAH81837.1 .
    PIRi S21765. JU0341.
    RefSeqi NP_037099.1. NM_012967.1.
    UniGenei Rn.12.

    3D structure databases

    ProteinModelPortali Q00238.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4997073.
    STRINGi 10116.ENSRNOP00000028066.

    PTM databases

    PhosphoSitei Q00238.

    Proteomic databases

    PaxDbi Q00238.
    PRIDEi Q00238.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028066 ; ENSRNOP00000028066 ; ENSRNOG00000020679 .
    GeneIDi 25464.
    KEGGi rno:25464.
    UCSCi RGD:2857. rat.

    Organism-specific databases

    CTDi 3383.
    RGDi 2857. Icam1.

    Phylogenomic databases

    eggNOGi NOG146347.
    GeneTreei ENSGT00530000063246.
    HOGENOMi HOG000059554.
    HOVERGENi HBG052074.
    InParanoidi Q00238.
    KOi K06490.
    OMAi RDCPGNW.
    OrthoDBi EOG7QG43X.
    PhylomeDBi Q00238.
    TreeFami TF333745.

    Miscellaneous databases

    NextBioi 606747.
    PROi Q00238.

    Gene expression databases

    Genevestigatori Q00238.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR003988. ICAM.
    IPR013768. ICAM_N.
    IPR003987. ICAM_VCAM_N.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    Pfami PF03921. ICAM_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01473. ICAM.
    PR01472. ICAMVCAM1.
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiICAM1_RAT
    AccessioniPrimary (citable) accession number: Q00238
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3