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Q00234 (TYRO_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosinase
EC=1.14.18.1
Alternative name(s):
Monophenol monooxygenase
Gene names
Name:melO
ORF Names:AO090038000061
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus ›

Protein attributes

Sequence length539 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activity

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.

L-tyrosine + O2 = dopaquinone + H2O.

Cofactor

Binds 2 copper ions per subunit.

Enzyme regulation

Activated by acidifying treatment at pH 3.0.

Subunit structure

Homotetramer.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the tyrosinase family.

Ontologies

Keywords
   Biological processMelanin biosynthesis
   LigandCopper
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   PTMThioether bond
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological_processmelanin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

monophenol monooxygenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 539539Tyrosinase
PRO_0000186733

Sites

Metal binding631Copper A By similarity
Metal binding841Copper A By similarity
Metal binding931Copper A By similarity
Metal binding2901Copper B By similarity
Metal binding2941Copper B By similarity
Metal binding3331Copper B By similarity

Amino acid modifications

Cross-link82 ↔ 842'-(S-cysteinyl)-histidine (Cys-His) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q00234 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CD2ECD702A018E15

FASTA53960,605
        10         20         30         40         50         60 
MASVEPIKTF EIRQKGPVET KAERKSIRDL NEEELDKLIE AWRWIQDPAR TGEDSFFYLA 

        70         80         90        100        110        120 
GLHGEPFRGA GYNNSHWWGG YCHHGNILFP TWHRAYLMAV EKALRKACPD VSLPYWDESD 

       130        140        150        160        170        180 
DETAKKGIPL IFTQKEYKGK PNPLYSYTFS ERIVDRLAKF PDADYSKPQG YKTCRYPYSG 

       190        200        210        220        230        240 
LCGQDDIAIA QQHNNFLDAN FNQEQITGLL NSNVTSWLNL GQFTDIEGKQ VKADTRWKIR 

       250        260        270        280        290        300 
QCLLTEEYTV FSNTTSAQRW NDEQFHPLES GGKETEAKAT SLAVPLESPH NDMHLAIGGV 

       310        320        330        340        350        360 
QIPGFNVDQY AGANGDMGEN DTASFDPIFY FHHCFIDYLF WTWQTMHKKT DASQITILPE 

       370        380        390        400        410        420 
YPGTNSVDSQ GPTPGISGNT WLTLDTPLDP FRENGDKVTS NKLLTLKDLP YTYKAPTSGT 

       430        440        450        460        470        480 
GSVFNDVPRL NYPLSPPILR VSGINRASIA GSFALAISQT DHTGKAQVKG IESVLSRWHV 

       490        500        510        520        530 
QGCANCQTHL STTAFVPLFE LNEDDAKRKH ANNELAVHLH TRGNPGGQRV RNVTVGTMR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D37929 Genomic DNA. Translation: BAA07149.1.
AP007169 Genomic DNA. Translation: BAE63910.1.
PIRS53529.
RefSeqXP_001825043.1. XM_001824991.2.

3D structure databases

ProteinModelPortalQ00234.
ModBaseSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00008707.

Proteomic databases

PRIDEQ00234.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAORAT00008890; CADAORAP00008707; CADAORAG00008890.
GeneID5997138.
KEGGaor:AOR_1_92074.

Phylogenomic databases

HOGENOMHOG000250264.
OrthoDBEOG46X2JC.

Family and domain databases

Gene3D1.10.1280.10. 3 hits.
InterProIPR016216. Monophenol_mOase_fun.
IPR002227. Tyrosinase.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamPF00264. Tyrosinase. 1 hit.
[Graphical view]
PIRSFPIRSF000340. MPO_fungal. 1 hit.
PRINTSPR00092. TYROSINASE.
SUPFAMSSF48056. Di-copper_centre. 1 hit.
PROSITEPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRO_ASPOR
AccessionPrimary (citable) accession number: Q00234
Secondary accession number(s): Q2U3F5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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