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Q00227 (COX2_MYTED) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismMytilus edulis (Blue mussel)
Taxonomic identifier6550 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Cytochrome c oxidase subunit 2
PRO_0000183636

Regions

Topological domain1 – 3030Mitochondrial intermembrane Potential
Transmembrane31 – 4717Helical; Potential
Topological domain48 – 6619Mitochondrial matrix Potential
Transmembrane67 – 8317Helical; Potential
Topological domain84 – 242159Mitochondrial intermembrane Potential

Sites

Metal binding1761Copper A Probable
Metal binding2111Copper A Probable
Metal binding2151Copper A Probable
Metal binding2191Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
Q00227 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: FC3FE2D3D15E4D56

FASTA24228,273
        10         20         30         40         50         60 
MSFYGSRYFG DIVHGELGKD LFRYHGFVMM VAVAVLVFVM YMGCVILFTK FSYRHFLNRQ 

        70         80         90        100        110        120 
RLEFWWTIVP MLMLVGLWXP SMINLYYMEE VKRPRWNFKA IGKQWYWSYE FCRNLDTPSS 

       130        140        150        160        170        180 
SESAESISCY TIDSYMEDQQ ETFSKGGYRL LDVDNRMVAP ADVQMTAFVS SSDVLHSFAL 

       190        200        210        220        230        240 
PKLLIKVDAI PGRINRLPMK ASQCSIIYGQ CSEICGVNHS FMPIVIEFIP EKYFVMWLEA 


LN 

« Hide

References

[1]"Complete sequences of the highly rearranged molluscan mitochondrial genomes of the scaphopod Graptacme eborea and the bivalve Mytilus edulis."
Boore J.L., Medina M., Rosenberg L.A.
Mol. Biol. Evol. 21:1492-1503(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"A novel mitochondrial genome organization for the blue mussel, Mytilus edulis."
Hoffmann R.J., Boore J.L., Brown W.M.
Genetics 131:397-412(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112 AND 162-242.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY484747 Genomic DNA. Translation: AAT98406.1.
PIRS28747.
RefSeqYP_073337.1. NC_006161.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ00227.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2960254.

Organism-specific databases

CTD4513.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_MYTED
AccessionPrimary (citable) accession number: Q00227
Secondary accession number(s): Q68SR6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families