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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Mytilus edulis (Blue mussel)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi176Copper ACurated1
Metal bindingi211Copper ACurated1
Metal bindingi215Copper ACurated1
Metal bindingi219Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiMytilus edulis (Blue mussel)
Taxonomic identifieri6550 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30Mitochondrial intermembraneSequence analysisAdd BLAST30
Transmembranei31 – 47HelicalSequence analysisAdd BLAST17
Topological domaini48 – 66Mitochondrial matrixSequence analysisAdd BLAST19
Transmembranei67 – 83HelicalSequence analysisAdd BLAST17
Topological domaini84 – 242Mitochondrial intermembraneSequence analysisAdd BLAST159

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836361 – 242Cytochrome c oxidase subunit 2Add BLAST242

Proteomic databases

PRIDEiQ00227

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q00227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFYGSRYFG DIVHGELGKD LFRYHGFVMM VAVAVLVFVM YMGCVILFTK
60 70 80 90 100
FSYRHFLNRQ RLEFWWTIVP MLMLVGLWXP SMINLYYMEE VKRPRWNFKA
110 120 130 140 150
IGKQWYWSYE FCRNLDTPSS SESAESISCY TIDSYMEDQQ ETFSKGGYRL
160 170 180 190 200
LDVDNRMVAP ADVQMTAFVS SSDVLHSFAL PKLLIKVDAI PGRINRLPMK
210 220 230 240
ASQCSIIYGQ CSEICGVNHS FMPIVIEFIP EKYFVMWLEA LN
Length:242
Mass (Da):28,273
Last modified:July 5, 2005 - v2
Checksum:iFC3FE2D3D15E4D56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484747 Genomic DNA Translation: AAT98406.1
PIRiS28747
RefSeqiYP_073337.1, NC_006161.1

Genome annotation databases

GeneIDi2960254

Similar proteinsi

Entry informationi

Entry nameiCOX2_MYTED
AccessioniPrimary (citable) accession number: Q00227
Secondary accession number(s): Q68SR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 5, 2005
Last modified: March 28, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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