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Q00227

- COX2_MYTED

UniProt

Q00227 - COX2_MYTED

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Protein
Cytochrome c oxidase subunit 2
Gene
COII
Organism
Mytilus edulis (Blue mussel)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi176 – 1761Copper A Inferred
Metal bindingi211 – 2111Copper A Inferred
Metal bindingi215 – 2151Copper A Inferred
Metal bindingi219 – 2191Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiMytilus edulis (Blue mussel)
Taxonomic identifieri6550 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei31 – 4717Helical; Reviewed prediction
Add
BLAST
Topological domaini48 – 6619Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei67 – 8317Helical; Reviewed prediction
Add
BLAST
Topological domaini84 – 242159Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Cytochrome c oxidase subunit 2
PRO_0000183636Add
BLAST

Proteomic databases

PRIDEiQ00227.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00227-1 [UniParc]FASTAAdd to Basket

« Hide

MSFYGSRYFG DIVHGELGKD LFRYHGFVMM VAVAVLVFVM YMGCVILFTK    50
FSYRHFLNRQ RLEFWWTIVP MLMLVGLWXP SMINLYYMEE VKRPRWNFKA 100
IGKQWYWSYE FCRNLDTPSS SESAESISCY TIDSYMEDQQ ETFSKGGYRL 150
LDVDNRMVAP ADVQMTAFVS SSDVLHSFAL PKLLIKVDAI PGRINRLPMK 200
ASQCSIIYGQ CSEICGVNHS FMPIVIEFIP EKYFVMWLEA LN 242
Length:242
Mass (Da):28,273
Last modified:July 5, 2005 - v2
Checksum:iFC3FE2D3D15E4D56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY484747 Genomic DNA. Translation: AAT98406.1.
PIRiS28747.
RefSeqiYP_073337.1. NC_006161.1.

Genome annotation databases

GeneIDi2960254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY484747 Genomic DNA. Translation: AAT98406.1 .
PIRi S28747.
RefSeqi YP_073337.1. NC_006161.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q00227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2960254.

Organism-specific databases

CTDi 4513.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequences of the highly rearranged molluscan mitochondrial genomes of the scaphopod Graptacme eborea and the bivalve Mytilus edulis."
    Boore J.L., Medina M., Rosenberg L.A.
    Mol. Biol. Evol. 21:1492-1503(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A novel mitochondrial genome organization for the blue mussel, Mytilus edulis."
    Hoffmann R.J., Boore J.L., Brown W.M.
    Genetics 131:397-412(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112 AND 162-242.

Entry informationi

Entry nameiCOX2_MYTED
AccessioniPrimary (citable) accession number: Q00227
Secondary accession number(s): Q68SR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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