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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2

Gene

tpsB

Organism
Aspergillus niger
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:tpsB
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2PRO_0000122495Add
BLAST

Proteomic databases

PRIDEiQ00217.

Structurei

3D structure databases

ProteinModelPortaliQ00217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 20 family.Curated

Phylogenomic databases

eggNOGiCOG0380.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q00217-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAANGSSSEG DHRLLIVSNR LPITIRRSGG GKYEFSMSSG GLVTGLSGLS
60 70 80 90 100
KTTTFQWYGW PGLEVPEDEI DSVKQRLQEE FNATPVFMDD KLADRHYNGF
110 120 130 140 150
SNSILWPLLH YHPGEIVFDE AAWDAYREAN RLFAKTIAHE AREGDLVWVH
160 170 180 190 200
DYHLMLLPEV LREELAALGK NNIRIGFFLH TPFPSSEIYR ILPVRSQLLR
210 220 230 240 250
GVLQCDLIGF HTYDYARHFL SCCSHILGLV TTPSSVKFKD RSVAVGAFPI
260 270 280 290 300
GIDPDKFTEG LKSPKVQNRI ASLENKFQGT KLMVSVDRLD YIKGIPQKLH
310 320 330 340 350
ALEVFLSQHP EWVGKVVLVQ VAVPSRQDVE EYQNLRAVVN ELVGRINGKF
360 370 380 390 400
GTVDYMPIHF MHKSVSFDEL IALYAASDAC VVSSTRDGMN LVSFEYVATQ
410 420 430 440 450
QKRKGVLILS EFAGAAQSLN GSIVVNPWNT EELASAYHEA VSMSDDLRAQ
460 470 480
KFEKLYKYIS KYTSAFWGKS FVAELSKCST
Length:480
Mass (Da):53,886
Last modified:November 1, 1997 - v1
Checksum:iDD0E89A1FF7F4C22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63416 Genomic DNA. Translation: AAB05869.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63416 Genomic DNA. Translation: AAB05869.1.

3D structure databases

ProteinModelPortaliQ00217.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Proteomic databases

PRIDEiQ00217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG0380.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The filamentous fungus Aspergillus niger contains two 'differentially regulated' trehalose-6-phosphate synthase-encoding genes, tpsA and tpsB."
    Wolschek M.F., Kubicek C.P.
    J. Biol. Chem. 272:2729-2735(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 11414 / NRRL 2270 / VTT D-77050.

Entry informationi

Entry nameiTPSB_ASPNG
AccessioniPrimary (citable) accession number: Q00217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.