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Protein

Calpain-like protease palB

Gene

palB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. Probably is the signaling protease that mediates the first proteolytic cleavage within the signaling protease box of pacC, yielding the 53 kDa 'open' conformation intermediate protein, which is committed to further processing. Required for virulence in invasive pulmonary aspergillosis (IPA).3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei198 – 1981PROSITE-ProRule annotation
Active sitei366 – 3661PROSITE-ProRule annotation
Active sitei386 – 3861PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular response to pH Source: ASPGD
  • penicillin biosynthetic process Source: ASPGD
  • positive regulation of penicillin biosynthetic process Source: ASPGD
  • proteolysis Source: GO_Central
  • regulation of secondary metabolite biosynthetic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-like protease palB (EC:3.4.22.-)
Alternative name(s):
Cysteine protease palB
Gene namesi
Name:palB
ORF Names:AN0256
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AN0256.

Subcellular locationi

GO - Cellular componenti

  • ESCRT III complex Source: ASPGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 847847Calpain-like protease palBPRO_0000207742Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ00204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8484MITAdd
BLAST
Domaini116 – 436321Calpain catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
Contains 1 MIT domain.Curated

Phylogenomic databases

HOGENOMiHOG000212111.
InParanoidiQ00204.
OMAiWIPEQIF.
OrthoDBiEOG092C185F.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTSSAPSQ KSLISRALKA ERDVITASSQ SQALDAAIDA AEHYMKALAL
60 70 80 90 100
TSSSKDRNVL DAKCKEWLTR AEKIKGSEDW RSVAQSRRSR LRTPASTRKL
110 120 130 140 150
TTREDIILLQ GAKLNGFIFP PWKAEPSLTE FETGTNGDVL FTDKPDLHLS
160 170 180 190 200
NLQRDIFAGW KRPHELLSGQ VDDAGMPLNP VMTVSGNTDL VQDVLTDCSV
210 220 230 240 250
VASLCATTSR SERGLDDTLL PIVYPCIHNS MKSDISPSGK YIFRFYFNGC
260 270 280 290 300
FRKVVIDDRL PSSKTSRSLY MIDRNHRNFM WPALVEKAYL KLRGGYEFPG
310 320 330 340 350
SNSGTDLWVL TGWIPEQVFL HSDEVTADQI WSDLFKSFHS GDVLLTIGTG
360 370 380 390 400
KLTEREQKEL GLVSEHDYAI LDMKELKGRR QFLIKNPWAG TDAVYPALFA
410 420 430 440 450
DPGPFPNSPF LSPGTFWMDC EMVLQNFENL YLNWNPGIFA YQEDIHFTWD
460 470 480 490 500
LSTGKGMAGC FVKNPQFSVY TERGGVVWLL LGRHLRTIES RASEEDERFG
510 520 530 540 550
FISIYVFKGG KRVALSDGAL HRGPYVDSPN TLMKLDVPPR STYTAVVSEE
560 570 580 590 600
SLPRVSQNFT ISAFSDSPVR ISHAPNKYIC VTKVQGSWTP TTAGGNAESA
610 620 630 640 650
RYSLNPQFSI VLSDPTDISI VLEPSDQELA THVKLFWSGG KRIARVRSRD
660 670 680 690 700
IVADSGDYRR GGSLVEKQDL DPGEYTIVVS TFAPDQYGSF TLWVSTNITC
710 720 730 740 750
EVTQLPSEAA GRRAVLSDIG VLLPGQDRML APLTTPRLTR VKLIARSRES
760 770 780 790 800
RIGNRPVGPS PLLMTVELGQ GPYKEILATS EDGDHSDSIS GVRVEDFDLQ
810 820 830 840
PGLEERGGVW IVLERIGGPG GQVEDHFEVE ALGEERVEIG EWIVEDA
Length:847
Mass (Da):94,129
Last modified:March 1, 2001 - v2
Checksum:i36A889BADEB32A39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54244 Genomic DNA. Translation: CAA91013.2.
AACD01000005 Genomic DNA. Translation: EAA66129.1.
BN001308 Genomic DNA. Translation: CBF89869.1.
RefSeqiXP_657860.1. XM_652768.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002468; CADANIAP00002468; CADANIAG00002468.
EAA66129; EAA66129; AN0256.2.
GeneIDi2876035.
KEGGiani:AN0256.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54244 Genomic DNA. Translation: CAA91013.2.
AACD01000005 Genomic DNA. Translation: EAA66129.1.
BN001308 Genomic DNA. Translation: CBF89869.1.
RefSeqiXP_657860.1. XM_652768.1.

3D structure databases

ProteinModelPortaliQ00204.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC02.008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00002468; CADANIAP00002468; CADANIAG00002468.
EAA66129; EAA66129; AN0256.2.
GeneIDi2876035.
KEGGiani:AN0256.2.

Organism-specific databases

EuPathDBiFungiDB:AN0256.

Phylogenomic databases

HOGENOMiHOG000212111.
InParanoidiQ00204.
OMAiWIPEQIF.
OrthoDBiEOG092C185F.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPALB_EMENI
AccessioniPrimary (citable) accession number: Q00204
Secondary accession number(s): C8VUJ8, Q5BGS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.