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Protein

POU domain, class 2, transcription factor 2

Gene

Pou2f2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform OCT2.5 activates the U2 small nuclear RNA (snRNA) promoter. Isoforms OCT2.1, OCT2.2 and OCT2.3 activate octamer-containing promoters. Isoforms OCT2.4 and OCT2.5 repress some promoters and activate others. Isoform OCT2.7 is unable to bind to the octamer motif, but can still activate the beta-casein gene promoter at low levels.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi281 – 34060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein domain specific binding Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  5. sequence-specific DNA binding Source: MGI
  6. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell maturation Source: MGI
  2. immunoglobulin secretion Source: MGI
  3. immunoglobulin secretion involved in immune response Source: MGI
  4. mature B cell differentiation Source: MGI
  5. positive regulation of transcription, DNA-templated Source: MGI
  6. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  7. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 2
Alternative name(s):
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
Octamer-binding protein 2
Short name:
Oct-2
Octamer-binding transcription factor 2
Short name:
OTF-2
Gene namesi
Name:Pou2f2
Synonyms:Oct2, Otf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:101897. Pou2f2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus PROSITE-ProRule annotation1 Publication
Note: In alveolus epithelial cells of mammary glands, present in the nucleus and cytoplasm. In HC11 mammary epithelial cells, present in the nucleus and preinuclear regions.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463POU domain, class 2, transcription factor 2PRO_0000100715Add
BLAST

Proteomic databases

MaxQBiQ00196.
PaxDbiQ00196.
PRIDEiQ00196.

PTM databases

PhosphoSiteiQ00196.

Expressioni

Tissue specificityi

Highest in B-cells, but also present in brain (neuronal and glial cells), intestine, kidney, and testes. Isoform OCT2.1 is expressed at higher levels in B-cells than in neuronal cells. Isoform OCT2.2 is expressed in neuronal cell lines and brain, but not dorsal root ganglia. Isoform OCT2.3 is expressed at lower levels in neuronal cells than in B-cells. Isoform OCT2.4 is expressed in neuronal cell lines, and at lower levels in neuroblastoma and dorsal root ganglia. Isoform OCT2.5 is widely expressed in the developing nervous system but expression is confined to very specific regions in the adult brain, it is expressed at a lower level in B-cells. Isoform OCT2.6 is either absent in, or expressed at very low levels in neuronal cells and brain. Isoform OCT2.7 is expressed in all tissues tested: mammary gland, liver, spleen, lung, kidney intestine, uterus and ovary of a virgin mouse. Levels of isoform OCT2.7 are highest in spleen and lung. In mammary gland, expression is localized to the alveolus epithelial cells.2 Publications

Developmental stagei

Widely but not homogeneously expressed in developing nervous system. Expression levels in mammary glands are barely detectable in virgin mice, levels increase during pregnancy, reaching a maximum during late pregnancy, then decrease during lactation becoming very low post-lactation.1 Publication

Gene expression databases

BgeeiQ00196.
CleanExiMM_POU2F2.
ExpressionAtlasiQ00196. baseline and differential.
GenevestigatoriQ00196.

Structurei

3D structure databases

ProteinModelPortaliQ00196.
SMRiQ00196. Positions 183-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 25375POU-specificPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni373 – 39422Leucine-zipperSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 826Poly-Pro
Compositional biasi401 – 4088Poly-Gly
Compositional biasi421 – 4244Poly-Pro

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG267922.
GeneTreeiENSGT00760000118935.
HOVERGENiHBG052783.
InParanoidiQ00196.
KOiK09364.
OMAiVPSVTSH.
OrthoDBiEOG7DJSMG.
PhylomeDBiQ00196.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform OCT2.1 (identifier: Q00196-1) [UniParc]FASTAAdd to basket

Also known as: Major form

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHSSMGAPE IRMSKPLEAE KQSLDSPSEH TDTERNGPDI NHQNPQNKAS
60 70 80 90 100
PFSVSPTGPS TKIKAEDPSG DSAPAAPPPP QPAQPHLPQA QLMLTGSQLA
110 120 130 140 150
GDIQQLLQLQ QLVLVPGHHL QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ
160 170 180 190 200
TQGALLTSQP RAGLPTQPPK CLEPPSHPEE PSDLEELEQF ARTFKQRRIK
210 220 230 240 250
LGFTQGDVGL AMGKLYGNDF SQTTISRFEA LNLSFKNMCK LKPLLEKWLN
260 270 280 290 300
DAETMSVDSS LPSPNQLSSP SLGFDGLPGR RRKKRTSIET NVRFALEKSF
310 320 330 340 350
LANQKPTSEE ILLIAEQLHM EKEVIRVWFC NRRQKEKRIN PCSAAPMLPS
360 370 380 390 400
PGKPTSYSPH LVTPQGGAGT LPLSQASSSL STTVTTLSSA VGTLHPSRTA
410 420 430 440 450
GGGGGGGGAA PPLNSIPSVT PPPPATTNST NPSPQGSHSA IGLSGLNPSA
460
GPGLWWNPAP YQP
Length:463
Mass (Da):49,439
Last modified:March 18, 2008 - v4
Checksum:iB6669B5885ABD789
GO
Isoform OCT2.2 (identifier: Q00196-2) [UniParc]FASTAAdd to basket

Also known as: OCT2a

The sequence of this isoform differs from the canonical sequence as follows:
     167-167: Q → QAMTRPTLPDPHLSHPQ

Note: The isoform OCT2b described in Ref.6 corresponds to the isoform OCT2a of Ref.1. To avoid any confusion, we use the nomenclature from Ref.2 to describe the different isoforms.

Show »
Length:479
Mass (Da):51,219
Checksum:i54F4280848EA87AA
GO
Isoform OCT2.3 (identifier: Q00196-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: K → KVGILSGLHLTFWGPGPCLSPPQ

Show »
Length:485
Mass (Da):51,698
Checksum:i737D181B5B999C4E
GO
Isoform OCT2.4 (identifier: Q00196-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     384-400: VTTLSSAVGTLHPSRTA → AQTRALKAATRLLACRA
     401-463: Missing.

Show »
Length:400
Mass (Da):43,649
Checksum:iDEEBC8432E8A900E
GO
Isoform OCT2.5 (identifier: Q00196-5) [UniParc]FASTAAdd to basket

Also known as: OCT2b

The sequence of this isoform differs from the canonical sequence as follows:
     452-463: PGLWWNPAPYQP → STMVGLSSGL...GGPEAGSKAE

Note: The isoform OCT2b described in Ref.6 corresponds to the isoform OCT2a of Ref.1. To avoid any confusion, we use the nomenclature from Ref.2 to describe the different isoforms.

Show »
Length:583
Mass (Da):60,141
Checksum:iDC702E46F07A7C55
GO
Isoform OCT2.6 (identifier: Q00196-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-101: Missing.

Show »
Length:424
Mass (Da):45,572
Checksum:i53F6B1E7C65A2BBA
GO
Isoform OCT2.7 (identifier: Q00196-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: K → KVGILSGLHLTFWGPGPCLSPPQ
     452-463: PGLWWNPAPYQP → STMVGLSSGL...LHPHLSSGKV

Show »
Length:549
Mass (Da):58,076
Checksum:iC48D3795D52A998C
GO

Sequence cautioni

The sequence AAU95617.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE33673.1 differs from that shown. Reason: Frameshift at position 412. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti409 – 4091A → R in CAA41004 (PubMed:2011512).Curated
Sequence conflicti409 – 4091A → R in CAA41005 (PubMed:2011512).Curated
Sequence conflicti409 – 4091A → R in CAA41006 (PubMed:2011512).Curated
Sequence conflicti409 – 4091A → R in CAA41008 (PubMed:2011512).Curated
Sequence conflicti409 – 4091A → R in CAA41009 (PubMed:2011512).Curated
Sequence conflicti411 – 4111P → L in CAA41004 (PubMed:2011512).Curated
Sequence conflicti411 – 4111P → L in CAA41005 (PubMed:2011512).Curated
Sequence conflicti411 – 4111P → L in CAA41006 (PubMed:2011512).Curated
Sequence conflicti411 – 4111P → L in CAA41008 (PubMed:2011512).Curated
Sequence conflicti411 – 4111P → L in CAA41009 (PubMed:2011512).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei62 – 621K → KVGILSGLHLTFWGPGPCLS PPQ in isoform OCT2.3 and isoform OCT2.7. 3 PublicationsVSP_002326
Alternative sequencei63 – 10139Missing in isoform OCT2.6. 1 PublicationVSP_002327Add
BLAST
Alternative sequencei167 – 1671Q → QAMTRPTLPDPHLSHPQ in isoform OCT2.2. 2 PublicationsVSP_002328
Alternative sequencei384 – 40017VTTLS…PSRTA → AQTRALKAATRLLACRA in isoform OCT2.4. 1 PublicationVSP_002329Add
BLAST
Alternative sequencei401 – 46363Missing in isoform OCT2.4. 1 PublicationVSP_002330Add
BLAST
Alternative sequencei452 – 46312PGLWW…APYQP → STMVGLSSGLSPALMSNNPL ATIQALASGGTLPLTSLDGS GNLVLGAAGAAPGSPSLVTS PLFLNHTGLPLLSAPPGVGL VSAAAAAVAASISSKSPGLS SSSSSSSSSTCSDVAAQTPG GPGGPEAGSKAE in isoform OCT2.5. 2 PublicationsVSP_002331Add
BLAST
Alternative sequencei452 – 46312PGLWW…APYQP → STMVGLSSGLSPALMSNNPL ATIQGACCLMSPHCHQSCPL LGLEPTLPHCCPSHAIPPPC SLHCSPLHPHLSSGKV in isoform OCT2.7. 1 PublicationVSP_032188Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53654 mRNA. Translation: CAA37702.1.
X57936 mRNA. Translation: CAA41004.1.
X57937 mRNA. Translation: CAA41005.1.
X57938 mRNA. Translation: CAA41006.1.
X57939 mRNA. Translation: CAA41007.1.
X57940 mRNA. Translation: CAA41008.1.
X57941 mRNA. Translation: CAA41009.1.
AY746973 mRNA. Translation: AAU95616.1.
AY746974 mRNA. Translation: AAU95617.1. Different initiation.
AK156322 mRNA. Translation: BAE33673.1. Frameshift.
BC104488 mRNA. Translation: AAI04489.1.
BC105647 mRNA. Translation: AAI05648.1.
BC105920 mRNA. Translation: AAI05921.1.
BC105921 mRNA. Translation: AAI05922.1.
X81031 Genomic DNA. Translation: CAA56934.1.
X51961 mRNA. Translation: CAA36220.1.
X57089 mRNA. Translation: CAA40369.1.
S55236 mRNA. Translation: AAA11815.1.
CCDSiCCDS39834.1. [Q00196-2]
CCDS52143.1. [Q00196-1]
CCDS52144.1. [Q00196-5]
CCDS52145.1. [Q00196-3]
PIRiS22539.
S22542.
S22543.
S22544.
RefSeqiNP_001157026.1. NM_001163554.1. [Q00196-5]
NP_001157027.1. NM_001163555.1. [Q00196-3]
NP_001157028.1. NM_001163556.1. [Q00196-1]
NP_035268.2. NM_011138.2. [Q00196-2]
XP_006539722.1. XM_006539659.2. [Q00196-7]
UniGeneiMm.76683.

Genome annotation databases

EnsembliENSMUST00000098679; ENSMUSP00000096276; ENSMUSG00000008496. [Q00196-7]
ENSMUST00000108413; ENSMUSP00000104051; ENSMUSG00000008496. [Q00196-4]
ENSMUST00000108415; ENSMUSP00000104053; ENSMUSG00000008496. [Q00196-2]
ENSMUST00000108416; ENSMUSP00000104054; ENSMUSG00000008496. [Q00196-6]
ENSMUST00000108417; ENSMUSP00000104055; ENSMUSG00000008496. [Q00196-3]
ENSMUST00000108418; ENSMUSP00000104056; ENSMUSG00000008496. [Q00196-5]
ENSMUST00000175774; ENSMUSP00000135075; ENSMUSG00000008496. [Q00196-1]
GeneIDi18987.
KEGGimmu:18987.
UCSCiuc009frm.1. mouse. [Q00196-7]
uc009frn.2. mouse. [Q00196-2]
uc009fro.2. mouse. [Q00196-5]
uc009frp.2. mouse. [Q00196-1]
uc009frq.2. mouse. [Q00196-3]
uc009frr.2. mouse. [Q00196-4]
uc012ffp.1. mouse. [Q00196-6]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53654 mRNA. Translation: CAA37702.1.
X57936 mRNA. Translation: CAA41004.1.
X57937 mRNA. Translation: CAA41005.1.
X57938 mRNA. Translation: CAA41006.1.
X57939 mRNA. Translation: CAA41007.1.
X57940 mRNA. Translation: CAA41008.1.
X57941 mRNA. Translation: CAA41009.1.
AY746973 mRNA. Translation: AAU95616.1.
AY746974 mRNA. Translation: AAU95617.1. Different initiation.
AK156322 mRNA. Translation: BAE33673.1. Frameshift.
BC104488 mRNA. Translation: AAI04489.1.
BC105647 mRNA. Translation: AAI05648.1.
BC105920 mRNA. Translation: AAI05921.1.
BC105921 mRNA. Translation: AAI05922.1.
X81031 Genomic DNA. Translation: CAA56934.1.
X51961 mRNA. Translation: CAA36220.1.
X57089 mRNA. Translation: CAA40369.1.
S55236 mRNA. Translation: AAA11815.1.
CCDSiCCDS39834.1. [Q00196-2]
CCDS52143.1. [Q00196-1]
CCDS52144.1. [Q00196-5]
CCDS52145.1. [Q00196-3]
PIRiS22539.
S22542.
S22543.
S22544.
RefSeqiNP_001157026.1. NM_001163554.1. [Q00196-5]
NP_001157027.1. NM_001163555.1. [Q00196-3]
NP_001157028.1. NM_001163556.1. [Q00196-1]
NP_035268.2. NM_011138.2. [Q00196-2]
XP_006539722.1. XM_006539659.2. [Q00196-7]
UniGeneiMm.76683.

3D structure databases

ProteinModelPortaliQ00196.
SMRiQ00196. Positions 183-343.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ00196.

Proteomic databases

MaxQBiQ00196.
PaxDbiQ00196.
PRIDEiQ00196.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098679; ENSMUSP00000096276; ENSMUSG00000008496. [Q00196-7]
ENSMUST00000108413; ENSMUSP00000104051; ENSMUSG00000008496. [Q00196-4]
ENSMUST00000108415; ENSMUSP00000104053; ENSMUSG00000008496. [Q00196-2]
ENSMUST00000108416; ENSMUSP00000104054; ENSMUSG00000008496. [Q00196-6]
ENSMUST00000108417; ENSMUSP00000104055; ENSMUSG00000008496. [Q00196-3]
ENSMUST00000108418; ENSMUSP00000104056; ENSMUSG00000008496. [Q00196-5]
ENSMUST00000175774; ENSMUSP00000135075; ENSMUSG00000008496. [Q00196-1]
GeneIDi18987.
KEGGimmu:18987.
UCSCiuc009frm.1. mouse. [Q00196-7]
uc009frn.2. mouse. [Q00196-2]
uc009fro.2. mouse. [Q00196-5]
uc009frp.2. mouse. [Q00196-1]
uc009frq.2. mouse. [Q00196-3]
uc009frr.2. mouse. [Q00196-4]
uc012ffp.1. mouse. [Q00196-6]

Organism-specific databases

CTDi5452.
MGIiMGI:101897. Pou2f2.

Phylogenomic databases

eggNOGiNOG267922.
GeneTreeiENSGT00760000118935.
HOVERGENiHBG052783.
InParanoidiQ00196.
KOiK09364.
OMAiVPSVTSH.
OrthoDBiEOG7DJSMG.
PhylomeDBiQ00196.
TreeFamiTF316413.

Miscellaneous databases

NextBioi295372.
PROiQ00196.
SOURCEiSearch...

Gene expression databases

BgeeiQ00196.
CleanExiMM_POU2F2.
ExpressionAtlasiQ00196. baseline and differential.
GenevestigatoriQ00196.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the mouse Oct2a and Oct2b, two differentially spliced products of the same gene."
    Hatzopoulos A.K., Stoykova A.S., Erselius J.R., Goulding M.D., Neuman T., Gruss P.
    Development 109:349-362(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS OCT2.2 AND OCT2.5).
    Tissue: B-cell.
  2. "Multiple Oct2 isoforms are generated by alternative splicing."
    Wirth T., Priess A., Annweiler A., Zwilling S., Oeler B.
    Nucleic Acids Res. 19:43-51(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS OCT2.1; OCT2.2; OCT2.3; OCT2.4; OCT2.5 AND OCT2.6), FUNCTION.
    Tissue: Pre-B cell.
  3. "Expression of the Oct-2 transcription factor in mouse mammary gland and cloning and characterization of a novel Oct-2 isoform."
    Dong B., Zhao F.-Q.
    Cell Tissue Res. 328:595-606(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OCT2.1), NUCLEOTIDE SEQUENCE [MRNA] OF 5-263 (ISOFORM OCT2.7), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C3H/HeN.
    Tissue: Mammary gland.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS OCT2.1 AND OCT2.3).
  6. "Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution."
    Matsuo K., Clay O., Kuenzler P., Georgiev O., Urbanek P., Schaffner W.
    Biol. Chem. Hoppe-Seyler 375:675-683(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 167-361 (ISOFORM OCT2.2).
    Strain: 129/Sv.
  7. "Cloning and sequencing of POU-boxes expressed in mouse testis."
    Goldsborough A., Ashworth A., Willison K.R.
    Nucleic Acids Res. 18:1634-1634(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 203-325 (ISOFORM OCT2.1).
    Strain: T6 / TW1.
    Tissue: Testis.
  8. "Interaction of Oct-binding transcription factors with a large series of 'noncanonical' oct-sequences. Primary sequence of murine Oct-2B cDNA."
    Stepchenko A.G.
    Dokl. Akad. Nauk SSSR 325:175-178(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OCT2.2).
  9. "Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-containing promoters."
    Lillycrop K.A., Latchman D.S.
    J. Biol. Chem. 267:24960-24965(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. "Mini-Oct and Oct-2c: two novel, functionally diverse murine Oct-2 gene products are differentially expressed in the CNS."
    Stoykova A.S., Sterrer S., Erselius J.R., Hatzopoulos A.K., Gruss P.
    Neuron 8:541-558(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  11. "Repression of a herpes simplex virus immediate-early promoter by the Oct-2 transcription factor is dependent on an inhibitory region at the N terminus of the protein."
    Lillycrop K.A., Dawson S.J., Estridge J.K., Gerster T., Matthias P., Latchman D.S.
    Mol. Cell. Biol. 14:7633-7642(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPO2F2_MOUSE
AccessioniPrimary (citable) accession number: Q00196
Secondary accession number(s): Q00197
, Q00198, Q00199, Q00200, Q00201, Q05882, Q3KR47, Q3U127, Q5XML1, Q5XML2, Q61995, Q61996, Q64245
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 18, 2008
Last modified: April 1, 2015
This is version 146 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.