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Q00195 (CNGA2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cyclic nucleotide-gated olfactory channel
Alternative name(s):
Cyclic nucleotide-gated cation channel 2
Cyclic nucleotide-gated channel alpha-2
Short name=CNG channel alpha-2
Short name=CNG-2
Short name=CNG2
Cyclic nucleotide-gated olfactory channel subunit OCNC1
Gene names
Name:Cnga2
Synonyms:Cncg2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length664 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Subunit structure

Heterooligomer of OCNC1 and OCNC2 subunits.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Olfactory neurons.

Sequence similarities

Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. [View classification]

Contains 1 cyclic nucleotide-binding domain.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 664664Cyclic nucleotide-gated olfactory channel
PRO_0000219315

Regions

Topological domain1 – 142142Cytoplasmic Potential
Transmembrane143 – 16220Helical; Name=H1; Potential
Topological domain163 – 17513Extracellular Potential
Transmembrane176 – 19419Helical; Name=H2; Potential
Topological domain195 – 21824Cytoplasmic Potential
Transmembrane219 – 23820Helical; Name=H3; Potential
Topological domain239 – 27638Extracellular Potential
Transmembrane277 – 29923Helical; Name=H4; Potential
Topological domain300 – 35152Cytoplasmic Potential
Transmembrane352 – 37120Helical; Name=H5; Potential
Topological domain372 – 45584Extracellular Potential
Transmembrane456 – 47621Helical; Name=H6; Potential
Topological domain477 – 664188Cytoplasmic Potential
Nucleotide binding464 – 586123cAMP By similarity

Sites

Binding site5231cAMP Potential
Binding site5381cAMP Potential

Amino acid modifications

Glycosylation3811N-linked (GlcNAc...) Potential

Natural variations

Natural variant2121K → R.

Sequences

Sequence LengthMass (Da)Tools
Q00195 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 720806950EC27F3C

FASTA66476,177
        10         20         30         40         50         60 
MMTEKSNGVK SSPANNHNHH PPPSIKANGK DDHRAGSRPQ SVAADDDTSP ELQRLAEMDT 

        70         80         90        100        110        120 
PRRGRGGFQR IVRLVGVIRD WANKNFREEE PRPDSFLERF RGPELQTVTT HQGDDKGGKD 

       130        140        150        160        170        180 
GEGKGTKKKF ELFVLDPAGD WYYRWLFVIA MPVLYNWCLL VARACFSDLQ RNYFVVWLVL 

       190        200        210        220        230        240 
DYFSDTVYIA DLIIRLRTGF LEQGLLVKDP KKLRDNYIHT LQFKLDVASI IPTDLIYFAV 

       250        260        270        280        290        300 
GIHSPEVRFN RLLHFARMFE FFDRTETRTS YPNIFRISNL VLYILVIIHW NACIYYVISK 

       310        320        330        340        350        360 
SIGFGVDTWV YPNITDPEYG YLAREYIYCL YWSTLTLTTI GETPPPVKDE EYLFVIFDFL 

       370        380        390        400        410        420 
IGVLIFATIV GNVGSMISNM NATRAEFQAK IDAVKHYMQF RKVSKDMEAK VIKWFDYLWT 

       430        440        450        460        470        480 
NKKTVDEREV LKNLPAKLRA EIAINVHLST LKKVRIFQDC EAGLLVELVL KLRPQVFSPG 

       490        500        510        520        530        540 
DYICRKGDIG KEMYIIKEGK LAVVADDGVT QYALLSAGSC FGEISILNIK GSKMGNRRTA 

       550        560        570        580        590        600 
NIRSLGYSDL FCLSKDDLME AVTEYPDAKK VLEERGREIL MKEGLLDENE VAASMEVDVQ 

       610        620        630        640        650        660 
EKLEQLETNM DTLYTRFARL LAEYTGAQQK LKQRITVLET KMKQNHEDDY LSDGINTPEP 


TAAE

« Hide

References

[1]"Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons."
Dhallan R.S., Yau K.-W., Schrader K.A., Reed R.R.
Nature 347:184-187(1990) [PubMed: 1697649] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Olfactory sensory neuron.
[2]"Molecular characterization and in situ localization of a full-length cyclic nucleotide-gated channel in rat brain."
Strijbos P.J., Pratt G.D., Khan S., Charles I.G., Garthwaite J.
Eur. J. Neurosci. 11:4463-4467(1999) [PubMed: 10594674] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X55519 mRNA. Translation: CAA39135.1.
AF126808 mRNA. Translation: AAD41473.1.
IPIIPI00196441.
PIRS11517.
RefSeqNP_037060.1. NM_012928.1.
UniGeneRn.10384.

3D structure databases

ProteinModelPortalQ00195.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ00195.

Proteomic databases

PRIDEQ00195.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25411.
KEGGrno:25411.
UCSCNM_012928. rat.

Organism-specific databases

CTD1260.
RGD2367. Cnga2.

Phylogenomic databases

eggNOGroNOG09747.
GeneTreeENSGT00550000074376.
HOVERGENHBG000281.
InParanoidQ00195.
OrthoDBEOG4N5VWD.

Gene expression databases

ArrayExpressQ00195.
GenevestigatorQ00195.
GermOnlineENSRNOG00000030119. Rattus norvegicus.

Family and domain databases

InterProIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
Gene3DG3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
KOK04949.
PfamPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR01463. EAGCHANLFMLY.
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. cNMP_binding. 1 hit.
PROSITEPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio606539.

Entry information

Entry nameCNGA2_RAT
AccessionPrimary (citable) accession number: Q00195
Secondary accession number(s): Q549G7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 16, 2011
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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