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Protein

Endo-1,4-beta-xylanase C

Gene

xlnC

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.2 Publications

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

pH dependencei

Optimum pH is 4.9.1 Publication

Temperature dependencei

Optimum temperature is 52 degrees Celsius.1 Publication

Pathwayi: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei154Proton donorBy similarity1
Active sitei262NucleophileBy similarity1

GO - Molecular functioni

  • endo-1,4-beta-xylanase activity Source: UniProtKB

GO - Biological processi

  • xylan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

BRENDAi3.2.1.8. 517.
UniPathwayiUPA00114.

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase C (EC:3.2.1.8)
Short name:
Xylanase C
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase C
34 kDa xylanase
Xylanase X34
Gene namesi
Name:xlnC
ORF Names:AN1818
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000000797425 – 327Endo-1,4-beta-xylanase CAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi280 ↔ 2861 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiQ00177.

Expressioni

Inductioni

Expressed in presence of xylan and repressed by glucose.1 Publication

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 35Combined sources7
Beta strandi39 – 45Combined sources7
Helixi47 – 51Combined sources5
Helixi53 – 62Combined sources10
Beta strandi64 – 70Combined sources7
Helixi74 – 77Combined sources4
Helixi87 – 98Combined sources12
Beta strandi102 – 109Combined sources8
Beta strandi111 – 113Combined sources3
Helixi116 – 119Combined sources4
Helixi124 – 141Combined sources18
Turni142 – 144Combined sources3
Beta strandi147 – 154Combined sources8
Beta strandi160 – 162Combined sources3
Helixi166 – 171Combined sources6
Helixi174 – 186Combined sources13
Beta strandi190 – 197Combined sources8
Helixi205 – 219Combined sources15
Beta strandi226 – 229Combined sources4
Helixi240 – 242Combined sources3
Helixi243 – 251Combined sources9
Beta strandi256 – 265Combined sources10
Helixi270 – 281Combined sources12
Beta strandi286 – 292Combined sources7
Helixi296 – 298Combined sources3
Helixi302 – 304Combined sources3
Beta strandi307 – 309Combined sources3
Helixi317 – 326Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TA3X-ray1.70B25-327[»]
ProteinModelPortaliQ00177.
SMRiQ00177.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00177.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 325GH10PROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Contains 1 GH10 (glycosyl hydrolase family 10) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000019847.
InParanoidiQ00177.
KOiK01181.
OrthoDBiEOG092C45ID.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001000. GH10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS51760. GH10_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLKTLAGS AVFASLATAA VLPRQSASLN DLFVAAGKSY FGTCSDQALL
60 70 80 90 100
QNSQNEAIVA SQFGVITPEN SMKWDALEPS QGNFGWSGAD YLVDYATQHN
110 120 130 140 150
KKVRGHTLVW HSQLPSWVSS IGDANTLRSV MTNHINEVVG RYKGKIMHWD
160 170 180 190 200
VVNEIFNEDG TFRNSVFYNL LGEDFVRIAF ETARAADPDA KLYINDYNLD
210 220 230 240 250
SASYAKTQAM ASYVKKWLAE GVPIDGIGSQ AHYSSSHWSS TEAAGALSSL
260 270 280 290 300
ANTGVSEVAI TELDIAGAAS SDYLNLLNAC LNEQKCVGIT VWGVSDKDSW
310 320
RASDSPLLFD GNYQPKDAYN AIVNALS
Length:327
Mass (Da):35,441
Last modified:November 1, 1996 - v1
Checksum:iB59CF4DE435F6F20
GO

Sequence cautioni

The sequence CBF85620 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA64983 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49894 Genomic DNA. Translation: CAA90075.1.
DQ490475 mRNA. Translation: ABF50851.1.
AACD01000029 Genomic DNA. Translation: EAA64983.1. Sequence problems.
BN001307 Genomic DNA. Translation: CBF85620.1. Sequence problems.
PIRiJC5034.
RefSeqiXP_659422.1. XM_654330.1.

Genome annotation databases

EnsemblFungiiCADANIAT00008467; CADANIAP00008467; CADANIAG00008467.
EAA64983; EAA64983; AN1818.2.
GeneIDi2874673.
KEGGiani:AN1818.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49894 Genomic DNA. Translation: CAA90075.1.
DQ490475 mRNA. Translation: ABF50851.1.
AACD01000029 Genomic DNA. Translation: EAA64983.1. Sequence problems.
BN001307 Genomic DNA. Translation: CBF85620.1. Sequence problems.
PIRiJC5034.
RefSeqiXP_659422.1. XM_654330.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TA3X-ray1.70B25-327[»]
ProteinModelPortaliQ00177.
SMRiQ00177.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.

Proteomic databases

PRIDEiQ00177.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00008467; CADANIAP00008467; CADANIAG00008467.
EAA64983; EAA64983; AN1818.2.
GeneIDi2874673.
KEGGiani:AN1818.2.

Phylogenomic databases

HOGENOMiHOG000019847.
InParanoidiQ00177.
KOiK01181.
OrthoDBiEOG092C45ID.

Enzyme and pathway databases

UniPathwayiUPA00114.
BRENDAi3.2.1.8. 517.

Miscellaneous databases

EvolutionaryTraceiQ00177.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001000. GH10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS51760. GH10_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYNC_EMENI
AccessioniPrimary (citable) accession number: Q00177
Secondary accession number(s): C8VPM8, Q1HFU9, Q5BCB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.