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Q00177

- XYNC_EMENI

UniProt

Q00177 - XYNC_EMENI

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Protein

Endo-1,4-beta-xylanase C

Gene

xlnC

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.2 Publications

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

pH dependencei

Optimum pH is 4.9.1 Publication

Temperature dependencei

Optimum temperature is 52 degrees Celsius.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541Proton donorBy similarity
Active sitei262 – 2621NucleophileBy similarity

GO - Molecular functioni

  1. endo-1,4-beta-xylanase activity Source: UniProtKB

GO - Biological processi

  1. xylan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3265-MONOMER.
BRENDAi3.2.1.8. 9578.
UniPathwayiUPA00114.

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase C (EC:3.2.1.8)
Short name:
Xylanase C
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase C
34 kDa xylanase
Xylanase X34
Gene namesi
Name:xlnC
ORF Names:AN1818
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VII

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 327303Endo-1,4-beta-xylanase CPRO_0000007974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Pyrrolidone carboxylic acidBy similarity
Disulfide bondi280 ↔ 2861 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Inductioni

Expressed in presence of xylan and repressed by glucose.1 Publication

Structurei

Secondary structure

1
327
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi29 – 357Combined sources
Beta strandi39 – 457Combined sources
Helixi47 – 515Combined sources
Helixi53 – 6210Combined sources
Beta strandi64 – 707Combined sources
Helixi74 – 774Combined sources
Helixi87 – 9812Combined sources
Beta strandi102 – 1098Combined sources
Beta strandi111 – 1133Combined sources
Helixi116 – 1194Combined sources
Helixi124 – 14118Combined sources
Turni142 – 1443Combined sources
Beta strandi147 – 1548Combined sources
Beta strandi160 – 1623Combined sources
Helixi166 – 1716Combined sources
Helixi174 – 18613Combined sources
Beta strandi190 – 1978Combined sources
Helixi205 – 21915Combined sources
Beta strandi226 – 2294Combined sources
Helixi240 – 2423Combined sources
Helixi243 – 2519Combined sources
Beta strandi256 – 26510Combined sources
Helixi270 – 28112Combined sources
Beta strandi286 – 2927Combined sources
Helixi296 – 2983Combined sources
Helixi302 – 3043Combined sources
Beta strandi307 – 3093Combined sources
Helixi317 – 32610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TA3X-ray1.70B25-327[»]
ProteinModelPortaliQ00177.
SMRiQ00177. Positions 27-327.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00177.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3693.
HOGENOMiHOG000019847.
InParanoidiQ00177.
KOiK01181.
OrthoDBiEOG7GJ6PM.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001000. Glyco_hydro_10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00177-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHLKTLAGS AVFASLATAA VLPRQSASLN DLFVAAGKSY FGTCSDQALL
60 70 80 90 100
QNSQNEAIVA SQFGVITPEN SMKWDALEPS QGNFGWSGAD YLVDYATQHN
110 120 130 140 150
KKVRGHTLVW HSQLPSWVSS IGDANTLRSV MTNHINEVVG RYKGKIMHWD
160 170 180 190 200
VVNEIFNEDG TFRNSVFYNL LGEDFVRIAF ETARAADPDA KLYINDYNLD
210 220 230 240 250
SASYAKTQAM ASYVKKWLAE GVPIDGIGSQ AHYSSSHWSS TEAAGALSSL
260 270 280 290 300
ANTGVSEVAI TELDIAGAAS SDYLNLLNAC LNEQKCVGIT VWGVSDKDSW
310 320
RASDSPLLFD GNYQPKDAYN AIVNALS
Length:327
Mass (Da):35,441
Last modified:November 1, 1996 - v1
Checksum:iB59CF4DE435F6F20
GO

Sequence cautioni

The sequence CBF85620.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAA64983.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49894 Genomic DNA. Translation: CAA90075.1.
DQ490475 mRNA. Translation: ABF50851.1.
AACD01000029 Genomic DNA. Translation: EAA64983.1. Sequence problems.
BN001307 Genomic DNA. Translation: CBF85620.1. Sequence problems.
PIRiJC5034.
RefSeqiXP_659422.1. XM_654330.1.

Genome annotation databases

EnsemblFungiiCADANIAT00008467; CADANIAP00008467; CADANIAG00008467.
GeneIDi2874673.
KEGGiani:AN1818.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49894 Genomic DNA. Translation: CAA90075.1 .
DQ490475 mRNA. Translation: ABF50851.1 .
AACD01000029 Genomic DNA. Translation: EAA64983.1 . Sequence problems.
BN001307 Genomic DNA. Translation: CBF85620.1 . Sequence problems.
PIRi JC5034.
RefSeqi XP_659422.1. XM_654330.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1TA3 X-ray 1.70 B 25-327 [» ]
ProteinModelPortali Q00177.
SMRi Q00177. Positions 27-327.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH10. Glycoside Hydrolase Family 10.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00008467 ; CADANIAP00008467 ; CADANIAG00008467 .
GeneIDi 2874673.
KEGGi ani:AN1818.2.

Phylogenomic databases

eggNOGi COG3693.
HOGENOMi HOG000019847.
InParanoidi Q00177.
KOi K01181.
OrthoDBi EOG7GJ6PM.

Enzyme and pathway databases

UniPathwayi UPA00114 .
BioCyci RETL1328306-WGS:GSTH-3265-MONOMER.
BRENDAi 3.2.1.8. 9578.

Miscellaneous databases

EvolutionaryTracei Q00177.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001000. Glyco_hydro_10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00331. Glyco_hydro_10. 1 hit.
[Graphical view ]
PRINTSi PR00134. GLHYDRLASE10.
SMARTi SM00633. Glyco_10. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, isolation and sequence of the Aspergillus nidulans xlnC gene encoding the 34-kDa xylanase."
    Maccabe A.P., Fernandez-Espinar M.-T., de Graaff L.H., Visser J., Ramon D.
    Gene 175:29-33(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
  2. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
    Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
    Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  4. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  5. "The dual nature of the wheat xylanase protein inhibitor XIP-I: structural basis for the inhibition of family 10 and family 11 xylanases."
    Payan F., Leone P., Porciero S., Furniss C., Tahir T., Williamson G., Durand A., Manzanares P., Gilbert H.J., Juge N., Roussel A.
    J. Biol. Chem. 279:36029-36037(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 25-327 IN COMPLEX WITH WHEAT XIP-1, DISULFIDE BOND.

Entry informationi

Entry nameiXYNC_EMENI
AccessioniPrimary (citable) accession number: Q00177
Secondary accession number(s): C8VPM8, Q1HFU9, Q5BCB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3