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Protein

Phosphatidylinositol transfer protein alpha isoform

Gene

PITPNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58Phosphatidylinositol lipid headgroup1 Publication1
Binding sitei60Phosphatidylinositol lipid headgroup1 Publication1
Binding sitei85Phosphatidylinositol lipid headgroup1 Publication1
Binding sitei89Phosphatidylinositol lipid headgroup1 Publication1
Binding sitei96Phosphatidylinositol lipid headgroup1 Publication1
Binding sitei194Phosphatidylinositol lipid headgroup1 Publication1

GO - Molecular functioni

  • phosphatidylcholine binding Source: BHF-UCL
  • phosphatidylcholine transporter activity Source: BHF-UCL
  • phosphatidylglycerol binding Source: BHF-UCL
  • phosphatidylinositol binding Source: BHF-UCL
  • phosphatidylinositol transporter activity Source: BHF-UCL

GO - Biological processi

  • lipid metabolic process Source: ProtInc
  • phospholipid transport Source: BHF-UCL
  • transport Source: BHF-UCL
  • visual perception Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174238-MONOMER.
ReactomeiR-HSA-418890. Role of second messengers in netrin-1 signaling.

Chemistry databases

SwissLipidsiSLP:000000415.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol transfer protein alpha isoform
Short name:
PI-TP-alpha
Short name:
PtdIns transfer protein alpha
Short name:
PtdInsTP alpha
Gene namesi
Name:PITPNA
Synonyms:PITPN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:9001. PITPNA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • myelin sheath Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5306.
OpenTargetsiENSG00000174238.
PharmGKBiPA33335.

Polymorphism and mutation databases

BioMutaiPITPNA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001916392 – 270Phosphatidylinositol transfer protein alpha isoformAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ00169.
PaxDbiQ00169.
PeptideAtlasiQ00169.
PRIDEiQ00169.

PTM databases

iPTMnetiQ00169.
PhosphoSitePlusiQ00169.

Expressioni

Tissue specificityi

Expressed in a wide range of tissues.

Gene expression databases

BgeeiENSG00000174238.
CleanExiHS_PITPNA.
ExpressionAtlasiQ00169. baseline and differential.
GenevisibleiQ00169. HS.

Organism-specific databases

HPAiHPA000528.

Interactioni

Protein-protein interaction databases

BioGridi111323. 17 interactors.
IntActiQ00169. 6 interactors.
STRINGi9606.ENSP00000316809.

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 13Combined sources11
Helixi15 – 33Combined sources19
Beta strandi38 – 49Combined sources12
Beta strandi54 – 65Combined sources12
Helixi70 – 73Combined sources4
Beta strandi81 – 90Combined sources10
Beta strandi93 – 99Combined sources7
Helixi101 – 103Combined sources3
Beta strandi106 – 120Combined sources15
Turni123 – 126Combined sources4
Helixi130 – 133Combined sources4
Beta strandi137 – 141Combined sources5
Helixi146 – 148Combined sources3
Helixi151 – 153Combined sources3
Helixi156 – 158Combined sources3
Helixi160 – 162Combined sources3
Turni166 – 168Combined sources3
Helixi177 – 182Combined sources6
Beta strandi190 – 200Combined sources11
Turni203 – 205Combined sources3
Helixi206 – 230Combined sources25
Helixi232 – 235Combined sources4
Helixi240 – 260Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UW5X-ray2.90A/B/C/D1-270[»]
ProteinModelPortaliQ00169.
SMRiQ00169.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00169.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3668. Eukaryota.
COG5083. LUCA.
GeneTreeiENSGT00760000119216.
HOVERGENiHBG058915.
InParanoidiQ00169.
OMAiMVLLKEY.
PhylomeDBiQ00169.
TreeFamiTF313279.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR001666. PI_transfer.
IPR023393. START-like_dom.
[Graphical view]
PANTHERiPTHR10658. PTHR10658. 1 hit.
PfamiPF02121. IP_trans. 1 hit.
[Graphical view]
PRINTSiPR00391. PITRANSFER.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK
60 70 80 90 100
DGEKGQYTHK IYHLQSKVPT FVRMLAPEGA LNIHEKAWNA YPYCRTVITN
110 120 130 140 150
EYMKEDFLIK IETWHKPDLG TQENVHKLEP EAWKHVEAVY IDIADRSQVL
160 170 180 190 200
SKDYKAEEDP AKFKSIKTGR GPLGPNWKQE LVNQKDCPYM CAYKLVTVKF
210 220 230 240 250
KWWGLQNKVE NFIHKQERRL FTNFHRQLFC WLDKWVDLTM DDIRRMEEET
260 270
KRQLDEMRQK DPVKGMTADD
Length:270
Mass (Da):31,806
Last modified:January 23, 2007 - v2
Checksum:i4531E6E38697C93B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45N → P in BAA06276 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73704 mRNA. Translation: AAA36441.1.
D30036 mRNA. Translation: BAA06276.1.
BC082976 mRNA. Translation: AAH82976.1.
BC045108 mRNA. Translation: AAH45108.1.
CCDSiCCDS45563.1.
PIRiI53775.
RefSeqiNP_006215.1. NM_006224.3.
UniGeneiHs.429819.

Genome annotation databases

EnsembliENST00000313486; ENSP00000316809; ENSG00000174238.
GeneIDi5306.
KEGGihsa:5306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73704 mRNA. Translation: AAA36441.1.
D30036 mRNA. Translation: BAA06276.1.
BC082976 mRNA. Translation: AAH82976.1.
BC045108 mRNA. Translation: AAH45108.1.
CCDSiCCDS45563.1.
PIRiI53775.
RefSeqiNP_006215.1. NM_006224.3.
UniGeneiHs.429819.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UW5X-ray2.90A/B/C/D1-270[»]
ProteinModelPortaliQ00169.
SMRiQ00169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111323. 17 interactors.
IntActiQ00169. 6 interactors.
STRINGi9606.ENSP00000316809.

Chemistry databases

SwissLipidsiSLP:000000415.

PTM databases

iPTMnetiQ00169.
PhosphoSitePlusiQ00169.

Polymorphism and mutation databases

BioMutaiPITPNA.

Proteomic databases

EPDiQ00169.
PaxDbiQ00169.
PeptideAtlasiQ00169.
PRIDEiQ00169.

Protocols and materials databases

DNASUi5306.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313486; ENSP00000316809; ENSG00000174238.
GeneIDi5306.
KEGGihsa:5306.

Organism-specific databases

CTDi5306.
DisGeNETi5306.
GeneCardsiPITPNA.
HGNCiHGNC:9001. PITPNA.
HPAiHPA000528.
MIMi600174. gene.
neXtProtiNX_Q00169.
OpenTargetsiENSG00000174238.
PharmGKBiPA33335.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3668. Eukaryota.
COG5083. LUCA.
GeneTreeiENSGT00760000119216.
HOVERGENiHBG058915.
InParanoidiQ00169.
OMAiMVLLKEY.
PhylomeDBiQ00169.
TreeFamiTF313279.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174238-MONOMER.
ReactomeiR-HSA-418890. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSiPITPNA. human.
EvolutionaryTraceiQ00169.
GeneWikiiPhosphatidylinositol_transfer_protein,_alpha.
GenomeRNAii5306.
PROiQ00169.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174238.
CleanExiHS_PITPNA.
ExpressionAtlasiQ00169. baseline and differential.
GenevisibleiQ00169. HS.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR001666. PI_transfer.
IPR023393. START-like_dom.
[Graphical view]
PANTHERiPTHR10658. PTHR10658. 1 hit.
PfamiPF02121. IP_trans. 1 hit.
[Graphical view]
PRINTSiPR00391. PITRANSFER.
ProtoNetiSearch...

Entry informationi

Entry nameiPIPNA_HUMAN
AccessioniPrimary (citable) accession number: Q00169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.