Phosphatidylinositol transfer protein alpha isoform

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Reviewed, UniProtKB/Swiss-Prot Q00169 (PIPNA_HUMAN)

Last modified November 25, 2008. Version 77. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Phosphatidylinositol transfer protein alpha isoform
      Short name=PtdIns transfer protein alpha
      Short name=PtdInsTP
      Short name=PI-TP-alpha

Gene names

Name:	PITPNA
Synonyms:	PITPN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
Subcellular location	Cytoplasm.
Tissue specificity	Expressed in a wide range of tissues.
Sequence similarities	Belongs to the PtdIns transfer protein family. Class I subfamily.

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Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Ligand	Lipid-binding
PTM	Phosphoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	lipid metabolic process Ref.1 Non-traceable author statement. Source: ProtInc transport Inferred from electronic annotation. Source: InterPro visual perception Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay. Source: HPA
Molecular function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylcholine transmembrane transporter activity Ref.1 Traceable author statement. Source: ProtInc phosphatidylinositol transporter activity Ref.1 Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
HSDL1	Q3SXM5	1	EBI-1042490,EBI-1056703
MLKL	Q8NB16	1	EBI-1042490,EBI-1055040
MORF4L2	Q15014	1	EBI-1042490,EBI-399257
PMVK	Q15126	1	EBI-1042490,EBI-1055562

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 270

269

Phosphatidylinositol transfer protein alpha isoform

PRO_0000191639

Amino acid modifications

Modified residue

Phosphotyrosine

Experimental info

Sequence conflict

N → P in BAA06276. Ref.2

Secondary structure

270

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q00169-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 4531E6E38697C93B
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FASTA

270

31,806

        10         20         30         40         50         60 
MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK DGEKGQYTHK 

        70         80         90        100        110        120 
IYHLQSKVPT FVRMLAPEGA LNIHEKAWNA YPYCRTVITN EYMKEDFLIK IETWHKPDLG 

       130        140        150        160        170        180 
TQENVHKLEP EAWKHVEAVY IDIADRSQVL SKDYKAEEDP AKFKSIKTGR GPLGPNWKQE 

       190        200        210        220        230        240 
LVNQKDCPYM CAYKLVTVKF KWWGLQNKVE NFIHKQERRL FTNFHRQLFC WLDKWVDLTM 

       250        260        270 
DDIRRMEEET KRQLDEMRQK DPVKGMTADD

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of a human cDNA encoding phosphatidylinositol transfer protein and occurrence of a related sequence in widely divergent eukaryotes." Dickeson S.K., Helmkamp G.M. Jr., Yarbrough L.R. Gene 142:301-305(1994) [PubMed: 8194769] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	Tanaka S., Yamashita S., Hosaka K. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Ovary.
[4]	Lubec G., Afjehi-Sadat L. Submitted (MAR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 135-146, MASS SPECTROMETRY. Tissue: Brain and Cajal-Retzius cell.
[5]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-57, MASS SPECTROMETRY. Tissue: Lung.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

M73704 mRNA. Translation: AAA36441.1.
D30036 mRNA. Translation: BAA06276.1.
BC082976 mRNA. Translation: AAH82976.1.
BC045108 mRNA. Translation: AAH45108.1.

PIR

I53775.

RefSeq

NP_006215.1.

UniGene

Hs.429819

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UW5	X-ray	2.90	A/B/C/D	1-270	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q00169.

PTM databases

PhosphoSite

Q00169.

Genome annotation databases

Ensembl

ENSG00000174238. Homo sapiens. [Contig view]

GeneID

5306.

KEGG

hsa:5306.

Organism-specific databases

H-InvDB

HIX0013400.

HGNC

HGNC:9001. PITPNA.

MIM

600174. gene.

PharmGKB

PA33335.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOVERGEN

Q00169.

Gene expression databases

ArrayExpress

Q00169.

CleanEx

HS_PITPNA.

GermOnline

ENSG00000174238. Homo sapiens.

Family and domain databases

InterPro

IPR001666. PI_transfer.
[Graphical view]

PANTHER

PTHR10658. PI_transfer. 1 hit.

Pfam

PF02121. IP_trans. 1 hit.
[Graphical view]

PRINTS

PR00391. PITRANSFER.

ProtoNet

Search...

Other Resources

NextBio

20510.

SOURCE

Search...

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Entry information

Entry name

PIPNA_HUMAN

Accession

Primary (citable) accession number: Q00169

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents