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Protein
Submitted name:

Pol protein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteaseUniRule annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Pol proteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R0WX-ray1.70A/B1-99[»]
3R0YX-ray1.65A/B1-99[»]
3SO9X-ray2.87A/B1-99[»]
3SPKX-ray1.24A/B1-99[»]
4EYRX-ray1.80A/B1-99[»]
4FAEX-ray2.30A/B1-99[»]
4FAFX-ray2.10A/B1-99[»]
4L1AX-ray1.90A/B1-99[»]
4NKKX-ray1.80A1-99[»]
SMRiQ000H7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ000H7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 89Peptidase A2InterPro annotationAdd BLAST70
Domaini143 – 333Reverse transcriptaseInterPro annotationAdd BLAST191

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Family and domain databases

CDDicd05482. HIV_retropepsin_like. 1 hit.
Gene3Di2.40.70.10. 1 hit.
InterProiView protein in InterPro
IPR001969. Aspartic_peptidase_AS.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR034170. Retropepsin-like_cat_dom.
IPR018061. Retropepsins.
IPR000477. RT_dom.
IPR010661. RVT_thumb.
PfamiView protein in Pfam
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06817. RVT_thumb. 1 hit.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q000H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PQITLWQRPI VTIKIGGQLK EALLDTGADD TVLEDINLPG RWKPKMIGGI
60 70 80 90 100
GGFVKVRQYD QVPIEICGHK VIGTVLVGPT PTNVIGRNLM TQIGCTLNFP
110 120 130 140 150
ISPIETVPVK LKPGMDGPKV KQWPLTEEKI KALIEICAEL EKEGKISKIG
160 170 180 190 200
PENPYNTPVF AIKKKNSTKW RKLVDFRELN KRTQDFWEVQ LGIPHPAGLK
210 220 230 240 250
KNKSVTVLDV GDAYFSVPLD EDFRKYTAFT IPSINNETPG IRYQYNVLPQ
260 270 280 290 300
GWKGSPSIFQ SSMTKILEPF RKQNPDIVIY QYVDDLYVGS DLEIGQHRAK
310 320 330 340 350
IDELRQHLWK WGFYTPEQKH QKEPPFLWMG YELHPDKWTV QPIVLPEKDS
360 370 380 390 400
WTVNDIQKLV GKLNWASQIY PGIKVRQLCK LLRGTKTLTE VVPLTREAEL

ELAE
Length:404
Mass (Da):46,066
Last modified:November 14, 2006 - v1
Checksum:i7F9B09F6308A139D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei404Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ988164 Genomic DNA. Translation: ABJ52797.1.

Similar proteinsi

Entry informationi

Entry nameiQ000H7_9HIV1
AccessioniPrimary (citable) accession number: Q000H7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: August 30, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Multifunctional enzymeSAAS annotation