Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q000H7

- Q000H7_9HIV1

UniProt

Q000H7 - Q000H7_9HIV1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Pol protein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW
  2. RNA-directed DNA polymerase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseUniRule annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Pol proteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R0WX-ray1.70A/B1-99[»]
3R0YX-ray1.65A/B1-99[»]
3SO9X-ray2.87A/B1-99[»]
3SPKX-ray1.24A/B1-99[»]
4EYRX-ray1.80A/B1-99[»]
4FAEX-ray2.30A/B1-99[»]
4FAFX-ray2.10A/B1-99[»]
4L1AX-ray1.90A/B1-99[»]
4NKKX-ray1.80A1-99[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ000H7.

Family & Domainsi

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation
Contains 1 reverse transcriptase domain.UniRule annotation
Contains peptidase A2 domain.SAAS annotation
Contains peptidase Adomain.SAAS annotation
Contains reverse transcriptase domain.SAAS annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR000477. RT_dom.
IPR010661. RVT_thumb.
[Graphical view]
PfamiPF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06817. RVT_thumb. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q000H7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PQITLWQRPI VTIKIGGQLK EALLDTGADD TVLEDINLPG RWKPKMIGGI
60 70 80 90 100
GGFVKVRQYD QVPIEICGHK VIGTVLVGPT PTNVIGRNLM TQIGCTLNFP
110 120 130 140 150
ISPIETVPVK LKPGMDGPKV KQWPLTEEKI KALIEICAEL EKEGKISKIG
160 170 180 190 200
PENPYNTPVF AIKKKNSTKW RKLVDFRELN KRTQDFWEVQ LGIPHPAGLK
210 220 230 240 250
KNKSVTVLDV GDAYFSVPLD EDFRKYTAFT IPSINNETPG IRYQYNVLPQ
260 270 280 290 300
GWKGSPSIFQ SSMTKILEPF RKQNPDIVIY QYVDDLYVGS DLEIGQHRAK
310 320 330 340 350
IDELRQHLWK WGFYTPEQKH QKEPPFLWMG YELHPDKWTV QPIVLPEKDS
360 370 380 390 400
WTVNDIQKLV GKLNWASQIY PGIKVRQLCK LLRGTKTLTE VVPLTREAEL

ELAE
Length:404
Mass (Da):46,066
Last modified:November 14, 2006 - v1
Checksum:i7F9B09F6308A139D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei404 – 4041Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ988164 Genomic DNA. Translation: ABJ52797.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ988164 Genomic DNA. Translation: ABJ52797.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3R0W X-ray 1.70 A/B 1-99 [» ]
3R0Y X-ray 1.65 A/B 1-99 [» ]
3SO9 X-ray 2.87 A/B 1-99 [» ]
3SPK X-ray 1.24 A/B 1-99 [» ]
4EYR X-ray 1.80 A/B 1-99 [» ]
4FAE X-ray 2.30 A/B 1-99 [» ]
4FAF X-ray 2.10 A/B 1-99 [» ]
4L1A X-ray 1.90 A/B 1-99 [» ]
4NKK X-ray 1.80 A 1-99 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q000H7.

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR000477. RT_dom.
IPR010661. RVT_thumb.
[Graphical view ]
Pfami PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06817. RVT_thumb. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Whitcomb J., Kiss L., Parkin N., Limoli K., Petropoulos C.J.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WAC2Imported.
  2. "The higher barrier of darunavir and tipranavir resistance for HIV-1 protease."
    Wang Y., Liu Z., Brunzelle J.S., Kovari I.A., Dewdney T.G., Reiter S.J., Kovari L.C.
    Biochem. Biophys. Res. Commun. 412:737-742(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.24 ANGSTROMS) OF 1-99.
  3. "Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds."
    Yedidi R.S., Liu Z., Wang Y., Brunzelle J.S., Kovari I.A., Woster P.M., Kovari L.C., Gupta D.
    Biochem. Biophys. Res. Commun. 421:413-417(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 1-99.
  4. "Higher desolvation energy reduces molecular recognition in multi-drug resistant HIV-1 protease."
    Wang Y., Dewdney T.G., Liu Z., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C.
    Submitted (MAY-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-99.
  5. "Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex."
    Liu Z., Yedidi R.S., Wang Y., Dewdney T.G., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C.
    Biochem. Biophys. Res. Commun. 431:232-238(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-99.
  6. "Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance."
    Liu Z., Yedidi R.S., Wang Y., Dewdney T.G., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C.
    Biochem. Biophys. Res. Commun. 437:199-204(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 1-99.
  7. "A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF."
    Yedidi R.S., Proteasa G., Martin P.D., Liu Z., Vickrey J.F., Kovari I.A., Kovari L.C.
    J. Mol. Graph. Model. 53C:105-111(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-99.

Entry informationi

Entry nameiQ000H7_9HIV1
AccessioniPrimary (citable) accession number: Q000H7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3