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Q000H7

- Q000H7_9HIV1

UniProt

Q000H7 - Q000H7_9HIV1

Protein
Submitted name:

Pol protein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed DNA polymerase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aspartyl proteaseUniRule annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Pol proteinImported
    Gene namesi
    Name:polImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3R0WX-ray1.70A/B1-99[»]
    3R0YX-ray1.65A/B1-99[»]
    3SO9X-ray2.87A/B1-99[»]
    3SPKX-ray1.24A/B1-99[»]
    4EYRX-ray1.80A/B1-99[»]
    4FAEX-ray2.30A/B1-99[»]
    4FAFX-ray2.10A/B1-99[»]
    4L1AX-ray1.90A/B1-99[»]
    4NKKX-ray1.80A1-99[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ000H7.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 reverse transcriptase domain.UniRule annotation
    Contains peptidase A2 domain.SAAS annotation
    Contains peptidase Adomain.SAAS annotation
    Contains reverse transcriptase domain.SAAS annotation

    Family and domain databases

    Gene3Di2.40.70.10. 1 hit.
    InterProiIPR001969. Aspartic_peptidase_AS.
    IPR018061. Pept_A2A_retrovirus_sg.
    IPR001995. Peptidase_A2_cat.
    IPR021109. Peptidase_aspartic_dom.
    IPR000477. RT_dom.
    IPR010661. RVT_thumb.
    [Graphical view]
    PfamiPF00077. RVP. 1 hit.
    PF00078. RVT_1. 1 hit.
    PF06817. RVT_thumb. 1 hit.
    [Graphical view]
    SUPFAMiSSF50630. SSF50630. 1 hit.
    PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
    PS00141. ASP_PROTEASE. 1 hit.
    PS50878. RT_POL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q000H7-1 [UniParc]FASTAAdd to Basket

    « Hide

    PQITLWQRPI VTIKIGGQLK EALLDTGADD TVLEDINLPG RWKPKMIGGI    50
    GGFVKVRQYD QVPIEICGHK VIGTVLVGPT PTNVIGRNLM TQIGCTLNFP 100
    ISPIETVPVK LKPGMDGPKV KQWPLTEEKI KALIEICAEL EKEGKISKIG 150
    PENPYNTPVF AIKKKNSTKW RKLVDFRELN KRTQDFWEVQ LGIPHPAGLK 200
    KNKSVTVLDV GDAYFSVPLD EDFRKYTAFT IPSINNETPG IRYQYNVLPQ 250
    GWKGSPSIFQ SSMTKILEPF RKQNPDIVIY QYVDDLYVGS DLEIGQHRAK 300
    IDELRQHLWK WGFYTPEQKH QKEPPFLWMG YELHPDKWTV QPIVLPEKDS 350
    WTVNDIQKLV GKLNWASQIY PGIKVRQLCK LLRGTKTLTE VVPLTREAEL 400
    ELAE 404
    Length:404
    Mass (Da):46,066
    Last modified:November 14, 2006 - v1
    Checksum:i7F9B09F6308A139D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei404 – 4041Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ988164 Genomic DNA. Translation: ABJ52797.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ988164 Genomic DNA. Translation: ABJ52797.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3R0W X-ray 1.70 A/B 1-99 [» ]
    3R0Y X-ray 1.65 A/B 1-99 [» ]
    3SO9 X-ray 2.87 A/B 1-99 [» ]
    3SPK X-ray 1.24 A/B 1-99 [» ]
    4EYR X-ray 1.80 A/B 1-99 [» ]
    4FAE X-ray 2.30 A/B 1-99 [» ]
    4FAF X-ray 2.10 A/B 1-99 [» ]
    4L1A X-ray 1.90 A/B 1-99 [» ]
    4NKK X-ray 1.80 A 1-99 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q000H7.

    Family and domain databases

    Gene3Di 2.40.70.10. 1 hit.
    InterProi IPR001969. Aspartic_peptidase_AS.
    IPR018061. Pept_A2A_retrovirus_sg.
    IPR001995. Peptidase_A2_cat.
    IPR021109. Peptidase_aspartic_dom.
    IPR000477. RT_dom.
    IPR010661. RVT_thumb.
    [Graphical view ]
    Pfami PF00077. RVP. 1 hit.
    PF00078. RVT_1. 1 hit.
    PF06817. RVT_thumb. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50630. SSF50630. 1 hit.
    PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
    PS00141. ASP_PROTEASE. 1 hit.
    PS50878. RT_POL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Whitcomb J., Kiss L., Parkin N., Limoli K., Petropoulos C.J.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WAC2Imported.
    2. "The higher barrier of darunavir and tipranavir resistance for HIV-1 protease."
      Wang Y., Liu Z., Brunzelle J.S., Kovari I.A., Dewdney T.G., Reiter S.J., Kovari L.C.
      Biochem. Biophys. Res. Commun. 412:737-742(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.24 ANGSTROMS) OF 1-99.
    3. "Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds."
      Yedidi R.S., Liu Z., Wang Y., Brunzelle J.S., Kovari I.A., Woster P.M., Kovari L.C., Gupta D.
      Biochem. Biophys. Res. Commun. 421:413-417(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 1-99.
    4. "Higher desolvation energy reduces molecular recognition in multi-drug resistant HIV-1 protease."
      Wang Y., Dewdney T.G., Liu Z., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C.
      Submitted (MAY-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-99.
    5. "Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex."
      Liu Z., Yedidi R.S., Wang Y., Dewdney T.G., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C.
      Biochem. Biophys. Res. Commun. 431:232-238(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-99.
    6. "Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance."
      Liu Z., Yedidi R.S., Wang Y., Dewdney T.G., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C.
      Biochem. Biophys. Res. Commun. 437:199-204(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 1-99.
    7. "A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF."
      Yedidi R.S., Proteasa G., Martin P.D., Liu Z., Vickrey J.F., Kovari I.A., Kovari L.C.
      Submitted (NOV-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-99.

    Entry informationi

    Entry nameiQ000H7_9HIV1
    AccessioniPrimary (citable) accession number: Q000H7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 14, 2006
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Multifunctional enzymeSAAS annotation

    External Data

    Dasty 3