Q00075 (TPSA_ASPNG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1
EC=2.4.1.15

Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase

Gene names

Name:	tpsA
Synonyms:	tps1

Organism

Aspergillus niger

Taxonomic identifier

5061 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.
Sequence similarities	Belongs to the glycosyltransferase 20 family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological_process	trehalose biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 517	517	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1		PRO_0000122494

Sequences

	Sequence		Length	Mass (Da)
	Q00075 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 8EF38ED40D66A1CC	FASTA	517	58,376
	10 20 30 40 50 60 MPSLENPTFQ NEARLLLVSN RLPITIKRSD DGRYDFSMSS GGLVSGLSGL SKSTTFQWYG 70 80 90 100 110 120 WPGLEVPEEE IPVVKERLKQ EYNAVPVFID DELADRHYNG FSNSILWPLF HYHPGEITFD 130 140 150 160 170 180 ESAWEAYKEA NRLFAKAVAK EVQDGDLIWV HDYHLMLLPE MLREEIGDSK ENVKIGFFLH 190 200 210 220 230 240 TPFPSSEIYR ILPVRNELLL GVLHCDLIGF HTYDYTRHFL SACSRLLGLT TTPNGIEFQG 250 260 270 280 290 300 KIIACGAFPI GIDPEKFEEG LKKEKVQKRI AMLEQKFQGV KLMVGVDRLD YIKGVPQKLH 310 320 330 340 350 360 ALEVFLSDHP EWVGKVVLVQ VAVPSRQDVE EYQNLRAVVN ELVGRINGKF GTVEFMPIHF 370 380 390 400 410 420 LHKSVNFDEL IALYAVSDAC IVSSTRDGMN LVAYEYIATQ KKRHGVLVLS EFAGAAQSLN 430 440 450 460 470 480 GSIIINPWNT EELAGAYQEA VTMSDEQRAL NFSKLDKYVN KYTSAFWGQS FVTELTRISE 490 500 510 HSAEKFHAKK ASFSDNNSEN GEPSNGVETP AQEQVAQ

References

[1]

"The filamentous fungus Aspergillus niger contains two 'differentially regulated' trehalose-6-phosphate synthase-encoding genes, tpsA and tpsB." Wolschek M.F., Kubicek C.P. J. Biol. Chem. 272:2729-2735(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 11414 / NRRL 2270 / VTT D-77050.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U07184 Unassigned DNA. Translation: AAA21861.1.
3D structure databases
ProteinModelPortal	Q00075.
ModBase	Search...
Protein family/group databases
CAZy	GT20. Glycosyltransferase Family 20.
Proteomic databases
PRIDE	Q00075.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG0380.
Family and domain databases
InterPro	IPR001830. Glyco_trans_20. IPR012766. Trehalose_OtsA. [Graphical view]
Pfam	PF00982. Glyco_transf_20. 1 hit. [Graphical view]
TIGRFAMs	TIGR02400. trehalose_OtsA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPSA_ASPNG

Accession

Primary (citable) accession number: Q00075

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program