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Q00063

- THRC_ASHGO

UniProt

Q00063 - THRC_ASHGO

Protein

Threonine synthase

Gene

THR4

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

    Catalytic activityi

    O-phospho-L-homoserine + H2O = L-threonine + phosphate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00050; UER00065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase (EC:4.2.3.1)
    Short name:
    TS
    Gene namesi
    Name:THR4
    Ordered Locus Names:AAR059C
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Threonine synthasePRO_0000185643Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei121 – 1211N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi33169.AGOS_AAR059C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00063.
    SMRiQ00063. Positions 2-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0498.
    HOGENOMiHOG000230745.
    KOiK01733.
    OMAiTASQRYL.
    OrthoDBiEOG7N0CDH.

    Family and domain databases

    Gene3Di3.90.1380.10. 1 hit.
    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q00063-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQVYRSTRS SSEDTKSFEE AVIQGLAEDG GLFLPAVIPR LREETLFEHW    50
    AHLSFQDLAM EIMKFYIADW EIPAPELREL IERSYSSFRS EEVTPLRKNV 100
    TGDDENLHIL ELFHGPTYAF KDVALQFVGN LFEYFLERKN RDVSEEERTH 150
    LTVVGATSGD TGSAAIYGLR GKQDVSVFIL YPHGRISPIQ EEQMTTVEDE 200
    NVHTMAIEGS FDNCQDIVKS IFVDEEFNRK HNIAAVNSIN WARILAQITY 250
    YFYSYFRATD GQPGRVKFIV PSGNFGDILA GFYAKQMGLP IEKLVIATNE 300
    NDILDRFLRE GVYERSEDVT ATHSPAMDIL VSSNFERLLW FFAREQLAQG 350
    DDQEAGSIVN RWFEQLREER RFDVPEHLLD AIRYHFDSER VDNYNTLASI 400
    RHIYEHAQNP ERYVIDPHTA VGICAANRQI AHDQNNEIHY ISLATAHPAK 450
    FADAVNEALS SYDDYNFDDV LPDRLRRLGD LEKRIKYVDN TDVDVIKSII 500
    EEELINMGIY NP 512
    Length:512
    Mass (Da):58,925
    Last modified:November 1, 1996 - v1
    Checksum:iE527C4E449881671
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91046 Genomic DNA. Translation: CAA62506.1.
    AE016814 Genomic DNA. Translation: AAS50424.1.
    PIRiS61905.
    RefSeqiNP_982600.1. NM_207953.1.

    Genome annotation databases

    EnsemblFungiiAAS50424; AAS50424; AGOS_AAR059C.
    GeneIDi4618427.
    KEGGiago:AGOS_AAR059C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91046 Genomic DNA. Translation: CAA62506.1 .
    AE016814 Genomic DNA. Translation: AAS50424.1 .
    PIRi S61905.
    RefSeqi NP_982600.1. NM_207953.1.

    3D structure databases

    ProteinModelPortali Q00063.
    SMRi Q00063. Positions 2-507.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_AAR059C.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAS50424 ; AAS50424 ; AGOS_AAR059C .
    GeneIDi 4618427.
    KEGGi ago:AGOS_AAR059C.

    Phylogenomic databases

    eggNOGi COG0498.
    HOGENOMi HOG000230745.
    KOi K01733.
    OMAi TASQRYL.
    OrthoDBi EOG7N0CDH.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00065 .

    Family and domain databases

    Gene3Di 3.90.1380.10. 1 hit.
    InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "AgTHR4, a new selection marker for transformation of the filamentous fungus Ashbya gossypii, maps in a four-gene cluster that is conserved between A. gossypii and Saccharomyces cerevisiae."
      Altmann-Joehl R., Philippsen P.
      Mol. Gen. Genet. 250:69-80(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    3. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiTHRC_ASHGO
    AccessioniPrimary (citable) accession number: Q00063
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3