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Reviewed, UniProtKB/Swiss-Prot Q00063 (THRC_ASHGO)

Last modified February 9, 2010. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Threonine synthase
      Short name=TS
    EC=4.2.3.1
Gene names
Name: THR4
Ordered Locus Names: AAR059C
OrganismAshbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]
Taxonomic identifier33169 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactor

Pyridoxal phosphate.

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.

Sequence similarities

Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

threonine synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Threonine synthase
PRO_0000185643

Amino acid modifications

Modified residue1211N6-(pyridoxal phosphate)lysine Probable

Sequences

Sequence LengthMass (Da)Tools
Q00063-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E527C4E449881671

FASTA51258,925
        10         20         30         40         50         60 
MSQVYRSTRS SSEDTKSFEE AVIQGLAEDG GLFLPAVIPR LREETLFEHW AHLSFQDLAM 

        70         80         90        100        110        120 
EIMKFYIADW EIPAPELREL IERSYSSFRS EEVTPLRKNV TGDDENLHIL ELFHGPTYAF 

       130        140        150        160        170        180 
KDVALQFVGN LFEYFLERKN RDVSEEERTH LTVVGATSGD TGSAAIYGLR GKQDVSVFIL 

       190        200        210        220        230        240 
YPHGRISPIQ EEQMTTVEDE NVHTMAIEGS FDNCQDIVKS IFVDEEFNRK HNIAAVNSIN 

       250        260        270        280        290        300 
WARILAQITY YFYSYFRATD GQPGRVKFIV PSGNFGDILA GFYAKQMGLP IEKLVIATNE 

       310        320        330        340        350        360 
NDILDRFLRE GVYERSEDVT ATHSPAMDIL VSSNFERLLW FFAREQLAQG DDQEAGSIVN 

       370        380        390        400        410        420 
RWFEQLREER RFDVPEHLLD AIRYHFDSER VDNYNTLASI RHIYEHAQNP ERYVIDPHTA 

       430        440        450        460        470        480 
VGICAANRQI AHDQNNEIHY ISLATAHPAK FADAVNEALS SYDDYNFDDV LPDRLRRLGD 

       490        500        510 
LEKRIKYVDN TDVDVIKSII EEELINMGIY NP 

« Hide

References

« Hide 'large scale' references
[1]"AgTHR4, a new selection marker for transformation of the filamentous fungus Ashbya gossypii, maps in a four-gene cluster that is conserved between A. gossypii and Saccharomyces cerevisiae."
Altmann-Joehl R., Philippsen P.
Mol. Gen. Genet. 250:69-80(1996) [PubMed: 8569689] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed: 15001715] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X91046 Genomic DNA. Translation: CAA62506.1.
AE016814 Genomic DNA. Translation: AAS50424.1.
PIRS61905.
RefSeqNP_982600.1.

3D structure databases

SMRQ00063. Positions 2-507.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ00063.

Genome annotation databases

GeneID4618427.
GenomeReviewsGene locus AAR059C in contig AE016814_GR.
KEGGago:AGOS_AAR059C.
NMPDRfig|33169.1.peg.245.

Organism-specific databases

AGDAAR059C.

Phylogenomic databases

eggNOGfuNOG05130.
HOGENOMHBG521025.
OMAYYFTSAV.
OrthoDBEOG9JQ5F2.

Enzyme and pathway databases

BioCycAGOS-XXX-01:AGOS-XXX-01-000245-MONOMER.
BRENDA4.2.3.1. 279361.

Family and domain databases

InterProIPR001926. PyrdxlP-dep_enz_bsu.
IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR004450. Thr_synthase.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
TIGRFAMsTIGR00260. thrC. 1 hit.
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHRC_ASHGO
AccessionPrimary (citable) accession number: Q00063
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Recent format changes

Overview of recent format changes

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents