Reviewed, UniProtKB/Swiss-Prot Q00063 (THRC_ASHGO)

Names and origin

Protein names

Recommended name:
    Threonine synthase
      Short name=TS
    EC=4.2.3.1

Gene names

Name:	THR4
Ordered Locus Names:	AAR059C

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	Threonine synthase		PRO_0000185643
Amino acid modifications
	Modified residue	121	1	N6-(pyridoxal phosphate)lysine Probable

Sequences

	Sequence		Length	Mass (Da)
	Q00063-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E527C4E449881671	FASTA	512	58,925
	10 20 30 40 50 60 MSQVYRSTRS SSEDTKSFEE AVIQGLAEDG GLFLPAVIPR LREETLFEHW AHLSFQDLAM 70 80 90 100 110 120 EIMKFYIADW EIPAPELREL IERSYSSFRS EEVTPLRKNV TGDDENLHIL ELFHGPTYAF 130 140 150 160 170 180 KDVALQFVGN LFEYFLERKN RDVSEEERTH LTVVGATSGD TGSAAIYGLR GKQDVSVFIL 190 200 210 220 230 240 YPHGRISPIQ EEQMTTVEDE NVHTMAIEGS FDNCQDIVKS IFVDEEFNRK HNIAAVNSIN 250 260 270 280 290 300 WARILAQITY YFYSYFRATD GQPGRVKFIV PSGNFGDILA GFYAKQMGLP IEKLVIATNE 310 320 330 340 350 360 NDILDRFLRE GVYERSEDVT ATHSPAMDIL VSSNFERLLW FFAREQLAQG DDQEAGSIVN 370 380 390 400 410 420 RWFEQLREER RFDVPEHLLD AIRYHFDSER VDNYNTLASI RHIYEHAQNP ERYVIDPHTA 430 440 450 460 470 480 VGICAANRQI AHDQNNEIHY ISLATAHPAK FADAVNEALS SYDDYNFDDV LPDRLRRLGD 490 500 510 LEKRIKYVDN TDVDVIKSII EEELINMGIY NP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AgTHR4, a new selection marker for transformation of the filamentous fungus Ashbya gossypii, maps in a four-gene cluster that is conserved between A. gossypii and Saccharomyces cerevisiae." Altmann-Joehl R., Philippsen P. Mol. Gen. Genet. 250:69-80(1996) [PubMed: 8569689] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]	"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X91046 Genomic DNA. Translation: CAA62506.1. AE016814 Genomic DNA. Translation: AAS50424.1.
PIR	S61905.
RefSeq	NP_982600.1.
3D structure databases
SMR	Q00063. Positions 2-507.
ModBase	Search...
Protein-protein interaction databases
STRING	Q00063.
Genome annotation databases
GeneID	4618427.
GenomeReviews	Gene locus AAR059C in contig AE016814_GR.
KEGG	ago:AGOS_AAR059C.
NMPDR	fig|33169.1.peg.245.
Organism-specific databases
AGD	AAR059C.
Phylogenomic databases
eggNOG	fuNOG05130.
HOGENOM	HBG521025.
OMA	YYFTSAV.
OrthoDB	EOG9JQ5F2.
Enzyme and pathway databases
BioCyc	AGOS-XXX-01:AGOS-XXX-01-000245-MONOMER.
BRENDA	4.2.3.1. 279361.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR004450. Thr_synthase. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_ASHGO

Accession

Primary (citable) accession number: Q00063

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)