GPD1

Functionⁱ

Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells.1 Publication

Catalytic activityⁱ

sn-glycerol 3-phosphate + NAD⁺ = glycerone phosphate + NADH.

Sites

Feature key	Position(s)	Length	Description
Binding siteⁱ	129 – 129	1	NADBy similarity
Binding siteⁱ	152 – 152	1	NAD; via amide nitrogenBy similarity
Binding siteⁱ	152 – 152	1	SubstrateBy similarity
Binding siteⁱ	185 – 185	1	NAD; via amide nitrogenBy similarity
Active siteⁱ	245 – 245	1	Proton acceptorBy similarity
Binding siteⁱ	310 – 310	1	NADBy similarity
Binding siteⁱ	339 – 339	1	NADBy similarity

Regions

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Nucleotide bindingⁱ	41 – 46	6	NADBy similarity

Enzyme and pathway databases

BioCycⁱ	MetaCyc:YDL022W-MONOMER. YEAST:YDL022W-MONOMER.
BRENDAⁱ	1.1.1.8. 984.
Reactomeⁱ	R-SCE-1483166. Synthesis of PA. R-SCE-75109. Triglyceride Biosynthesis.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycerol-3-phosphate dehydrogenase [NAD(+)] 1 (EC:1.1.1.8)
Gene namesⁱ	Name:GPD1 Synonyms:DAR1, HOR1, OSG1 Ordered Locus Names:YDL022W ORF Names:D2830
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IV

Organism-specific databases

EuPathDBⁱ	FungiDB:YDL022W.
SGDⁱ	S000002180. GPD1.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol
Source: SGD
Inferred from direct assayⁱ
- 15210723
glycerol-3-phosphate dehydrogenase complex Source: InterPro
nucleus
Source: SGD
Inferred from direct assayⁱ
- 20026609
peroxisome
Source: SGD
Inferred from direct assayⁱ
- 15210723

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Peroxisome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Initiator methionineⁱ			Removed1 Publication Manual assertion based on experiment inⁱ Ref.9 Bienvenut W.V., Peters C. Submitted (JUN-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-19 AND 271-278, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
Chainⁱ	2 – 391	390	Glycerol-3-phosphate dehydrogenase [NAD(+)] 1		PRO_0000138100	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Modified residueⁱ	2 – 2	1	N-acetylserine1 Publication Manual assertion based on experiment inⁱ Ref.9 Bienvenut W.V., Peters C. Submitted (JUN-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-19 AND 271-278, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
Modified residueⁱ	24 – 24	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.16 "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24 AND SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	27 – 27	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.14 "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N. Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Ref.16 "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24 AND SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Ref.18 "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution." Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O. Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

MaxQBⁱ	Q00055.
TopDownProteomicsⁱ	Q00055.

PTM databases

iPTMnetⁱ	Q00055.

iPTMnetⁱ

Q00055.

Expressionⁱ

Inductionⁱ

By osmotic stress and by methylglyoxal in a HOG pathway-dependent manner.2 Publications

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	32033. 58 interactions.
DIPⁱ	DIP-6393N.
IntActⁱ	Q00055. 3 interactions.
MINTⁱ	MINT-2788005.

Structureⁱ

Secondary structure

1

391

Legend: HelixTurnBeta strand

Show more details

Feature key	Position(s)	Length	Description
Beta strandⁱ	35 – 40	6	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	44 – 59	16	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Turnⁱ	61 – 63	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	64 – 71	8	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	76 – 79	4	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	82 – 86	5	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Turnⁱ	87 – 89	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Turnⁱ	93 – 95	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	103 – 109	7	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	111 – 115	5	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	119 – 123	5	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	127 – 129	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	130 – 137	8	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Turnⁱ	138 – 140	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	146 – 149	4	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	155 – 157	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	160 – 162	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	164 – 172	9	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	175 – 180	6	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	185 – 189	5	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	194 – 199	6	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	209 – 212	4	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	215 – 222	8	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Beta strandⁱ	227 – 233	7	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	235 – 257	23	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	261 – 283	23	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	289 – 294	6	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Turnⁱ	296 – 298	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	299 – 307	9	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	310 – 320	11	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	325 – 333	9	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	340 – 354	15	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	361 – 371	11	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW
Helixⁱ	379 – 383	5	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:4FGW

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4FGW	X-ray	2.45	A/B	1-391	[»]

ProteinModelPortalⁱ

Q00055.

SMRⁱ

Q00055. Positions 33-385.

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Regionⁱ	310 – 311	2	Substrate bindingBy similarity

Sequence similaritiesⁱ

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.Curated

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000003114.
HOGENOMⁱ	HOG000246855.
InParanoidⁱ	Q00055.
KOⁱ	K00006.
OMAⁱ	FPESNDN.
OrthoDBⁱ	EOG092C3ZQP.

Family and domain databases

Gene3Dⁱ	1.10.1040.10. 1 hit. 3.40.50.720. 1 hit.
InterProⁱ	IPR008927. 6-PGluconate_DH_C-like. IPR013328. 6PGD_dom_2. IPR006168. G3P_DH_NAD-dep. IPR006109. G3P_DH_NAD-dep_C. IPR017751. G3P_DH_NAD-dep_euk. IPR011128. G3P_DH_NAD-dep_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfamⁱ	PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSⁱ	PR00077. GPDHDRGNASE.
SUPFAMⁱ	SSF48179. SSF48179. 1 hit. SSF51735. SSF51735. 1 hit.
TIGRFAMsⁱ	TIGR03376. glycerol3P_DH. 1 hit.
PROSITEⁱ	PS00957. NAD_G3PDH. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q00055-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAAADRLNL TSGHLNAGRK RSSSSVSLKA AEKPFKVTVI GSGNWGTTIA 
        60         70         80         90        100
KVVAENCKGY PEVFAPIVQM WVFEEEINGE KLTEIINTRH QNVKYLPGIT 
       110        120        130        140        150
LPDNLVANPD LIDSVKDVDI IVFNIPHQFL PRICSQLKGH VDSHVRAISC 
       160        170        180        190        200
LKGFEVGAKG VQLLSSYITE ELGIQCGALS GANIATEVAQ EHWSETTVAY 
       210        220        230        240        250
HIPKDFRGEG KDVDHKVLKA LFHRPYFHVS VIEDVAGISI CGALKNVVAL 
       260        270        280        290        300
GCGFVEGLGW GNNASAAIQR VGLGEIIRFG QMFFPESREE TYYQESAGVA 
       310        320        330        340        350
DLITTCAGGR NVKVARLMAT SGKDAWECEK ELLNGQSAQG LITCKEVHEW 
       360        370        380        390 
LETCGSVEDF PLFEAVYQIV YNNYPMKNLP DMIEELDLHE D

Length:391

Mass (Da):42,869

Last modified:January 23, 2007 - v4

Checksum:ⁱF5F1F7F111F707D1

GO

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Sequence conflictⁱ	103 – 107	5	DNLVA → TIWLL in AAA18631 (PubMed:1676389).Curated

Natural variant

Feature key	Position(s)	Length	Description
Natural variantⁱ	16 – 16	1	N → D in strain: WFB. 1 Publication Manual assertion based on experiment inⁱ Ref.4 "Research on the mechanism of osmotolerance and thermotolerance of yeast." Ma X., Guo Y., Zhang F., Yu H., Kuang J., Yao J., Li Z., He G. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-16; ALA-143; PRO-164; SER-183; SER-225 AND VAL-256.
Natural variantⁱ	143 – 143	1	S → A in strain: WFB. 1 Publication Manual assertion based on experiment inⁱ Ref.4 "Research on the mechanism of osmotolerance and thermotolerance of yeast." Ma X., Guo Y., Zhang F., Yu H., Kuang J., Yao J., Li Z., He G. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-16; ALA-143; PRO-164; SER-183; SER-225 AND VAL-256.
Natural variantⁱ	164 – 164	1	L → P in strain: WFB. 1 Publication Manual assertion based on experiment inⁱ Ref.4 "Research on the mechanism of osmotolerance and thermotolerance of yeast." Ma X., Guo Y., Zhang F., Yu H., Kuang J., Yao J., Li Z., He G. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-16; ALA-143; PRO-164; SER-183; SER-225 AND VAL-256.
Natural variantⁱ	183 – 183	1	N → S in strain: WFB. 1 Publication Manual assertion based on experiment inⁱ Ref.4 "Research on the mechanism of osmotolerance and thermotolerance of yeast." Ma X., Guo Y., Zhang F., Yu H., Kuang J., Yao J., Li Z., He G. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-16; ALA-143; PRO-164; SER-183; SER-225 AND VAL-256.
Natural variantⁱ	225 – 225	1	P → S in strain: WFB. 1 Publication Manual assertion based on experiment inⁱ Ref.4 "Research on the mechanism of osmotolerance and thermotolerance of yeast." Ma X., Guo Y., Zhang F., Yu H., Kuang J., Yao J., Li Z., He G. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-16; ALA-143; PRO-164; SER-183; SER-225 AND VAL-256.
Natural variantⁱ	256 – 256	1	E → V in strain: WFB. 1 Publication Manual assertion based on experiment inⁱ Ref.4 "Research on the mechanism of osmotolerance and thermotolerance of yeast." Ma X., Guo Y., Zhang F., Yu H., Kuang J., Yao J., Li Z., He G. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-16; ALA-143; PRO-164; SER-183; SER-225 AND VAL-256.

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z24454 Genomic DNA. Translation: CAA80827.1. X76859 Genomic DNA. Translation: CAA54189.1. U04621 Genomic DNA. Translation: AAA64936.1. AY598965 Genomic DNA. Translation: AAT27375.1. AY598968 Genomic DNA. Translation: AAT27378.1. Z48432 Genomic DNA. Translation: CAA88337.1. Z74071 Genomic DNA. Translation: CAA98582.1. EF596737 Genomic DNA. Translation: ABQ58864.1. M38740 Genomic DNA. Translation: AAA18631.1. BK006938 Genomic DNA. Translation: DAA11828.1.
PIRⁱ	S40059.
RefSeqⁱ	NP_010262.1. NM_001180081.1.

Genome annotation databases

EnsemblFungiⁱ	YDL022W; YDL022W; YDL022W.
GeneIDⁱ	851539.
KEGGⁱ	sce:YDL022W.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z24454 Genomic DNA. Translation: CAA80827.1. X76859 Genomic DNA. Translation: CAA54189.1. U04621 Genomic DNA. Translation: AAA64936.1. AY598965 Genomic DNA. Translation: AAT27375.1. AY598968 Genomic DNA. Translation: AAT27378.1. Z48432 Genomic DNA. Translation: CAA88337.1. Z74071 Genomic DNA. Translation: CAA98582.1. EF596737 Genomic DNA. Translation: ABQ58864.1. M38740 Genomic DNA. Translation: AAA18631.1. BK006938 Genomic DNA. Translation: DAA11828.1.
PIRⁱ	S40059.
RefSeqⁱ	NP_010262.1. NM_001180081.1.

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4FGW	X-ray	2.45	A/B	1-391	[»]

ProteinModelPortalⁱ

Q00055.

SMRⁱ

Q00055. Positions 33-385.

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Protein-protein interaction databases

BioGridⁱ	32033. 58 interactions.
DIPⁱ	DIP-6393N.
IntActⁱ	Q00055. 3 interactions.
MINTⁱ	MINT-2788005.

PTM databases

iPTMnetⁱ	Q00055.

iPTMnetⁱ

Q00055.

Proteomic databases

MaxQBⁱ	Q00055.
TopDownProteomicsⁱ	Q00055.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YDL022W; YDL022W; YDL022W.
GeneIDⁱ	851539.
KEGGⁱ	sce:YDL022W.

Organism-specific databases

EuPathDBⁱ	FungiDB:YDL022W.
SGDⁱ	S000002180. GPD1.

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000003114.
HOGENOMⁱ	HOG000246855.
InParanoidⁱ	Q00055.
KOⁱ	K00006.
OMAⁱ	FPESNDN.
OrthoDBⁱ	EOG092C3ZQP.

Enzyme and pathway databases

BioCycⁱ	MetaCyc:YDL022W-MONOMER. YEAST:YDL022W-MONOMER.
BRENDAⁱ	1.1.1.8. 984.
Reactomeⁱ	R-SCE-1483166. Synthesis of PA. R-SCE-75109. Triglyceride Biosynthesis.

Miscellaneous databases

PROⁱ	Q00055.

PROⁱ

Q00055.

Family and domain databases

Gene3Dⁱ	1.10.1040.10. 1 hit. 3.40.50.720. 1 hit.
InterProⁱ	IPR008927. 6-PGluconate_DH_C-like. IPR013328. 6PGD_dom_2. IPR006168. G3P_DH_NAD-dep. IPR006109. G3P_DH_NAD-dep_C. IPR017751. G3P_DH_NAD-dep_euk. IPR011128. G3P_DH_NAD-dep_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfamⁱ	PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSⁱ	PR00077. GPDHDRGNASE.
SUPFAMⁱ	SSF48179. SSF48179. 1 hit. SSF51735. SSF51735. 1 hit.
TIGRFAMsⁱ	TIGR03376. glycerol3P_DH. 1 hit.
PROSITEⁱ	PS00957. NAD_G3PDH. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

GPD1_YEAST

Accessionⁱ

Primary (citable) accession number: Q00055
Secondary accession number(s): A5YWB0

Q6J5J5

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	January 23, 2007
Last modified:	September 7, 2016
This is version 168 of the entry and version 4 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Miscellaneousⁱ

Miscellaneous

Present with 807 molecules/cell in log phase SD medium.1 Publication

Caution

Was originally thought to be GUT2, the FAD-dependent glycerol-3-phosphate dehydrogenase.1 Publication

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q00055 (GPD1_YEAST)

UniProt

Q00055 - GPD1_YEAST

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Glycerol-3-phosphate dehydrogenase [NAD(+)] 1

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Miscellaneous

Caution

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ