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Q00030 (DUT_EHV4) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:9
Synonyms:B3
OrganismEquine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Taxonomic identifier10333 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostEquus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182953

Sequences

Sequence LengthMass (Da)Tools
Q00030 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: C0825CB752D36D58

FASTA32635,173
        10         20         30         40         50         60 
MASATNLADN IVVVECSNGW EARAEADGRL LVLINNHTVE LSAGLGSAGE FYSVLTDVGV 

        70         80         90        100        110        120 
RVACSSGYAI VLAQISGLPH VGREPGNFSN ITFTGNLANY YTAYGIVDSG YRGVVKAVQF 

       130        140        150        160        170        180 
ANGVNTVVPP GCMSLGLVLV KLSTETINVT NINLTENGRS PRVNIFYDYF APKRDEDAGY 

       190        200        210        220        230        240 
DISAQTNATI EPDESYFVEL PIVFSSSNPA VTPCIFGRSS MNRRGLIVLP TRWVTGRTCC 

       250        260        270        280        290        300 
FFILNINKYP VYITKGQRVA QLVLTEDIDE ALIPTNVNYN TPFPTYSPTG AVKHNPTPIL 

       310        320 
WKFTEAFDHD APSSARSEGG FGSTGL 

« Hide

References

[1]"Antigenic and protein sequence homology between VP13/14, a herpes simplex virus type 1 tegument protein, and gp10, a glycoprotein of equine herpesvirus 1 and 4."
Whittaker G.R., Riggio M.P., Halliburton I.W., Killington R.A., Allen G.P., Meredith D.M.
J. Virol. 65:2320-2326(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17684 Genomic DNA. Translation: CAA35671.1.
PIRS36705.

3D structure databases

ProteinModelPortalQ00030.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_EHV4
AccessionPrimary (citable) accession number: Q00030
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 16, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families