Q00030 (DUT_EHV4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

Name:	9
Synonyms:	B3

Organism

Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)

Taxonomic identifier

10333 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › Equid herpesvirus 4

Virus host

Equus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000182953

Sequences

	Sequence		Length	Mass (Da)
	Q00030 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: C0825CB752D36D58	FASTA	326	35,173
	10 20 30 40 50 60 MASATNLADN IVVVECSNGW EARAEADGRL LVLINNHTVE LSAGLGSAGE FYSVLTDVGV 70 80 90 100 110 120 RVACSSGYAI VLAQISGLPH VGREPGNFSN ITFTGNLANY YTAYGIVDSG YRGVVKAVQF 130 140 150 160 170 180 ANGVNTVVPP GCMSLGLVLV KLSTETINVT NINLTENGRS PRVNIFYDYF APKRDEDAGY 190 200 210 220 230 240 DISAQTNATI EPDESYFVEL PIVFSSSNPA VTPCIFGRSS MNRRGLIVLP TRWVTGRTCC 250 260 270 280 290 300 FFILNINKYP VYITKGQRVA QLVLTEDIDE ALIPTNVNYN TPFPTYSPTG AVKHNPTPIL 310 320 WKFTEAFDHD APSSARSEGG FGSTGL

References

[1]

"Antigenic and protein sequence homology between VP13/14, a herpes simplex virus type 1 tegument protein, and gp10, a glycoprotein of equine herpesvirus 1 and 4." Whittaker G.R., Riggio M.P., Halliburton I.W., Killington R.A., Allen G.P., Meredith D.M. J. Virol. 65:2320-2326(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17684 Genomic DNA. Translation: CAA35671.1.
PIR	S36705.
3D structure databases
ProteinModelPortal	Q00030.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_EHV4

Accession

Primary (citable) accession number: Q00030

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program