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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:9, B3
OrganismiEquine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Taxonomic identifieri10333 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829531 – 326Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST326

Structurei

3D structure databases

ProteinModelPortaliQ00030
SMRiQ00030
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 220Substrate bindingUniRule annotation3
Regioni321 – 322Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Family and domain databases

Gene3Di2.70.40.10, 1 hit
HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 2 hits

Sequencei

Sequence statusi: Complete.

Q00030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASATNLADN IVVVECSNGW EARAEADGRL LVLINNHTVE LSAGLGSAGE
60 70 80 90 100
FYSVLTDVGV RVACSSGYAI VLAQISGLPH VGREPGNFSN ITFTGNLANY
110 120 130 140 150
YTAYGIVDSG YRGVVKAVQF ANGVNTVVPP GCMSLGLVLV KLSTETINVT
160 170 180 190 200
NINLTENGRS PRVNIFYDYF APKRDEDAGY DISAQTNATI EPDESYFVEL
210 220 230 240 250
PIVFSSSNPA VTPCIFGRSS MNRRGLIVLP TRWVTGRTCC FFILNINKYP
260 270 280 290 300
VYITKGQRVA QLVLTEDIDE ALIPTNVNYN TPFPTYSPTG AVKHNPTPIL
310 320
WKFTEAFDHD APSSARSEGG FGSTGL
Length:326
Mass (Da):35,173
Last modified:December 1, 1992 - v1
Checksum:iC0825CB752D36D58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17684 Genomic DNA Translation: CAA35671.1
PIRiS36705

Similar proteinsi

Entry informationi

Entry nameiDUT_EHV4
AccessioniPrimary (citable) accession number: Q00030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 25, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health