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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:9, B3
OrganismiEquine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Taxonomic identifieri10333 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829531 – 326Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST326

Structurei

3D structure databases

ProteinModelPortaliQ00030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 220Substrate bindingUniRule annotation3
Regioni321 – 322Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_04031. HSV_DUT. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

Q00030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASATNLADN IVVVECSNGW EARAEADGRL LVLINNHTVE LSAGLGSAGE
60 70 80 90 100
FYSVLTDVGV RVACSSGYAI VLAQISGLPH VGREPGNFSN ITFTGNLANY
110 120 130 140 150
YTAYGIVDSG YRGVVKAVQF ANGVNTVVPP GCMSLGLVLV KLSTETINVT
160 170 180 190 200
NINLTENGRS PRVNIFYDYF APKRDEDAGY DISAQTNATI EPDESYFVEL
210 220 230 240 250
PIVFSSSNPA VTPCIFGRSS MNRRGLIVLP TRWVTGRTCC FFILNINKYP
260 270 280 290 300
VYITKGQRVA QLVLTEDIDE ALIPTNVNYN TPFPTYSPTG AVKHNPTPIL
310 320
WKFTEAFDHD APSSARSEGG FGSTGL
Length:326
Mass (Da):35,173
Last modified:December 1, 1992 - v1
Checksum:iC0825CB752D36D58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17684 Genomic DNA. Translation: CAA35671.1.
PIRiS36705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17684 Genomic DNA. Translation: CAA35671.1.
PIRiS36705.

3D structure databases

ProteinModelPortaliQ00030.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_04031. HSV_DUT. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDUT_EHV4
AccessioniPrimary (citable) accession number: Q00030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: July 6, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.