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Q00030

- DUT_EHV4

UniProt

Q00030 - DUT_EHV4

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene
9, B3
Organism
Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:9
Synonyms:B3
OrganismiEquine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Taxonomic identifieri10333 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182953Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ00030.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

Q00030-1 [UniParc]FASTAAdd to Basket

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MASATNLADN IVVVECSNGW EARAEADGRL LVLINNHTVE LSAGLGSAGE    50
FYSVLTDVGV RVACSSGYAI VLAQISGLPH VGREPGNFSN ITFTGNLANY 100
YTAYGIVDSG YRGVVKAVQF ANGVNTVVPP GCMSLGLVLV KLSTETINVT 150
NINLTENGRS PRVNIFYDYF APKRDEDAGY DISAQTNATI EPDESYFVEL 200
PIVFSSSNPA VTPCIFGRSS MNRRGLIVLP TRWVTGRTCC FFILNINKYP 250
VYITKGQRVA QLVLTEDIDE ALIPTNVNYN TPFPTYSPTG AVKHNPTPIL 300
WKFTEAFDHD APSSARSEGG FGSTGL 326
Length:326
Mass (Da):35,173
Last modified:December 1, 1992 - v1
Checksum:iC0825CB752D36D58
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17684 Genomic DNA. Translation: CAA35671.1.
PIRiS36705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17684 Genomic DNA. Translation: CAA35671.1 .
PIRi S36705.

3D structure databases

ProteinModelPortali Q00030.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Antigenic and protein sequence homology between VP13/14, a herpes simplex virus type 1 tegument protein, and gp10, a glycoprotein of equine herpesvirus 1 and 4."
    Whittaker G.R., Riggio M.P., Halliburton I.W., Killington R.A., Allen G.P., Meredith D.M.
    J. Virol. 65:2320-2326(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDUT_EHV4
AccessioniPrimary (citable) accession number: Q00030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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