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P9WQP5

- 6PGL_MYCTU

UniProt

P9WQP5 - 6PGL_MYCTU

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Protein

6-phosphogluconolactonase

Gene
pgl, devB, Rv1445c, MTCY493.09
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:Rv1445c
ORF Names:MTCY493.09
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001584: Chromosome

Organism-specific databases

TubercuListiRv1445c.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2472476-phosphogluconolactonasePRO_0000090101Add
BLAST

Structurei

Secondary structure

1
247
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 107
Helixi11 – 3323
Beta strandi36 – 405
Helixi44 – 5613
Helixi57 – 593
Helixi62 – 643
Beta strandi65 – 739
Helixi83 – 908
Helixi92 – 943
Helixi99 – 1013
Turni111 – 1144
Helixi116 – 13015
Beta strandi141 – 1455
Helixi161 – 1644
Beta strandi169 – 1746
Beta strandi177 – 1815
Beta strandi183 – 1864
Helixi188 – 1914
Beta strandi194 – 2018
Helixi204 – 2063
Helixi207 – 2148
Turni219 – 2213
Helixi223 – 2264
Beta strandi230 – 2389
Helixi239 – 2424

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ICOX-ray2.15A/B/C/D1-247[»]
ProteinModelPortaliP9WQP5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01057.
PhylomeDBiP9WQP5.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WQP5-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSIEIFPD SDILVAAAGK RLVGAIGAAV AARGQALIVL TGGGNGIALL    50
RYLSAQAQQI EWSKVHLFWG DERYVPEDDD ERNLKQARRA LLNHVDIPSN 100
QVHPMAASDG DFGGDLDAAA LAYEQVLAAS AAPGDPAPNF DVHLLGMGPE 150
GHINSLFPHS PAVLESTRMV VAVDDSPKPP PRRITLTLPA IQRSREVWLL 200
VSGPGKADAV AAAIGGADPV SVPAAGAVGR QNTLWLLDRD AAAKLPS 247
Length:247
Mass (Da):25,804
Last modified:April 16, 2014 - v1
Checksum:i1639B68A595D7D2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP44204.1.
PIRiH70916.
RefSeqiNP_215961.1. NC_000962.3.
YP_006514828.1. NC_018143.2.

Genome annotation databases

GeneIDi13320037.
886617.
KEGGimtu:Rv1445c.
mtv:RVBD_1445c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP44204.1 .
PIRi H70916.
RefSeqi NP_215961.1. NC_000962.3.
YP_006514828.1. NC_018143.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ICO X-ray 2.15 A/B/C/D 1-247 [» ]
ProteinModelPortali P9WQP5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13320037.
886617.
KEGGi mtu:Rv1445c.
mtv:RVBD_1445c.

Organism-specific databases

TubercuListi Rv1445c.

Phylogenomic databases

KOi K01057.
PhylomeDBi P9WQP5.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00409 .

Family and domain databases

InterProi IPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view ]
Pfami PF01182. Glucosamine_iso. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01198. pgl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry namei6PGL_MYCTU
AccessioniPrimary (citable) accession number: P9WQP5
Secondary accession number(s): L0T9F2, O06814, P63338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 3, 2014
This is version 5 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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