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P9WQP5

- 6PGL_MYCTU

UniProt

P9WQP5 - 6PGL_MYCTU

Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 6 (01 Oct 2014)
      Sequence version 1 (16 Apr 2014)
      Previous versions | rss
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    Functioni

    Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconolactonase (EC:3.1.1.31)
    Short name:
    6PGL
    Gene namesi
    Name:pgl
    Synonyms:devB
    Ordered Locus Names:Rv1445c
    ORF Names:MTCY493.09
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001584: Chromosome

    Organism-specific databases

    TubercuListiRv1445c.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: MTBBASE

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2472476-phosphogluconolactonasePRO_0000090101Add
    BLAST

    Structurei

    Secondary structure

    1
    247
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 107
    Helixi11 – 3323
    Beta strandi36 – 405
    Helixi44 – 5613
    Helixi57 – 593
    Helixi62 – 643
    Beta strandi65 – 739
    Helixi83 – 908
    Helixi92 – 943
    Helixi99 – 1013
    Turni111 – 1144
    Helixi116 – 13015
    Beta strandi141 – 1455
    Helixi161 – 1644
    Beta strandi169 – 1746
    Beta strandi177 – 1815
    Beta strandi183 – 1864
    Helixi188 – 1914
    Beta strandi194 – 2018
    Helixi204 – 2063
    Helixi207 – 2148
    Turni219 – 2213
    Helixi223 – 2264
    Beta strandi230 – 2389
    Helixi239 – 2424

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ICOX-ray2.15A/B/C/D1-247[»]
    ProteinModelPortaliP9WQP5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK01057.
    PhylomeDBiP9WQP5.

    Family and domain databases

    InterProiIPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view]
    PfamiPF01182. Glucosamine_iso. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01198. pgl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P9WQP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSIEIFPD SDILVAAAGK RLVGAIGAAV AARGQALIVL TGGGNGIALL    50
    RYLSAQAQQI EWSKVHLFWG DERYVPEDDD ERNLKQARRA LLNHVDIPSN 100
    QVHPMAASDG DFGGDLDAAA LAYEQVLAAS AAPGDPAPNF DVHLLGMGPE 150
    GHINSLFPHS PAVLESTRMV VAVDDSPKPP PRRITLTLPA IQRSREVWLL 200
    VSGPGKADAV AAAIGGADPV SVPAAGAVGR QNTLWLLDRD AAAKLPS 247
    Length:247
    Mass (Da):25,804
    Last modified:April 16, 2014 - v1
    Checksum:i1639B68A595D7D2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP44204.1.
    PIRiH70916.
    RefSeqiNP_215961.1. NC_000962.3.
    YP_006514828.1. NC_018143.2.

    Genome annotation databases

    GeneIDi13320037.
    886617.
    KEGGimtu:Rv1445c.
    mtv:RVBD_1445c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP44204.1 .
    PIRi H70916.
    RefSeqi NP_215961.1. NC_000962.3.
    YP_006514828.1. NC_018143.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ICO X-ray 2.15 A/B/C/D 1-247 [» ]
    ProteinModelPortali P9WQP5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 13320037.
    886617.
    KEGGi mtu:Rv1445c.
    mtv:RVBD_1445c.

    Organism-specific databases

    TubercuListi Rv1445c.

    Phylogenomic databases

    KOi K01057.
    PhylomeDBi P9WQP5.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .

    Family and domain databases

    InterProi IPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view ]
    Pfami PF01182. Glucosamine_iso. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01198. pgl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37Rv.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ATCC 25618 / H37Rv.

    Entry informationi

    Entry namei6PGL_MYCTU
    AccessioniPrimary (citable) accession number: P9WQP5
    Secondary accession number(s): L0T9F2, O06814, P63338
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2014
    Last sequence update: April 16, 2014
    Last modified: October 1, 2014
    This is version 6 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
      Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3