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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 2 (zwf2), Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase 1 (zwf1), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd1)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5628-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:Rv1445c
ORF Names:MTCY493.09
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1445c.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000901011 – 2476-phosphogluconolactonaseAdd BLAST247

Proteomic databases

PaxDbiP9WQP5.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1445c.

Structurei

Secondary structure

1247
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Helixi11 – 33Combined sources23
Beta strandi36 – 40Combined sources5
Helixi44 – 56Combined sources13
Helixi57 – 59Combined sources3
Helixi62 – 64Combined sources3
Beta strandi65 – 73Combined sources9
Helixi83 – 90Combined sources8
Helixi92 – 94Combined sources3
Helixi99 – 101Combined sources3
Turni111 – 114Combined sources4
Helixi116 – 130Combined sources15
Beta strandi141 – 145Combined sources5
Helixi161 – 164Combined sources4
Beta strandi169 – 174Combined sources6
Beta strandi177 – 181Combined sources5
Beta strandi183 – 186Combined sources4
Helixi188 – 191Combined sources4
Beta strandi194 – 201Combined sources8
Helixi204 – 206Combined sources3
Helixi207 – 214Combined sources8
Turni219 – 221Combined sources3
Helixi223 – 226Combined sources4
Beta strandi230 – 238Combined sources9
Helixi239 – 242Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ICOX-ray2.15A/B/C/D1-247[»]
ProteinModelPortaliP9WQP5.
SMRiP9WQP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107XU2. Bacteria.
COG0363. LUCA.
KOiK01057.
OMAiYWGDERC.
PhylomeDBiP9WQP5.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WQP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSIEIFPD SDILVAAAGK RLVGAIGAAV AARGQALIVL TGGGNGIALL
60 70 80 90 100
RYLSAQAQQI EWSKVHLFWG DERYVPEDDD ERNLKQARRA LLNHVDIPSN
110 120 130 140 150
QVHPMAASDG DFGGDLDAAA LAYEQVLAAS AAPGDPAPNF DVHLLGMGPE
160 170 180 190 200
GHINSLFPHS PAVLESTRMV VAVDDSPKPP PRRITLTLPA IQRSREVWLL
210 220 230 240
VSGPGKADAV AAAIGGADPV SVPAAGAVGR QNTLWLLDRD AAAKLPS
Length:247
Mass (Da):25,804
Last modified:April 16, 2014 - v1
Checksum:i1639B68A595D7D2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44204.1.
PIRiH70916.
RefSeqiNP_215961.1. NC_000962.3.
WP_003407433.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44204; CCP44204; Rv1445c.
GeneIDi886617.
KEGGimtu:Rv1445c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44204.1.
PIRiH70916.
RefSeqiNP_215961.1. NC_000962.3.
WP_003407433.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ICOX-ray2.15A/B/C/D1-247[»]
ProteinModelPortaliP9WQP5.
SMRiP9WQP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1445c.

Proteomic databases

PaxDbiP9WQP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44204; CCP44204; Rv1445c.
GeneIDi886617.
KEGGimtu:Rv1445c.

Organism-specific databases

TubercuListiRv1445c.

Phylogenomic databases

eggNOGiENOG4107XU2. Bacteria.
COG0363. LUCA.
KOiK01057.
OMAiYWGDERC.
PhylomeDBiP9WQP5.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciMTBH37RV:G185E-5628-MONOMER.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei6PGL_MYCTU
AccessioniPrimary (citable) accession number: P9WQP5
Secondary accession number(s): L0T9F2, O06814, P63338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 2, 2016
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.