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Protein

Iron import ATP-binding/permease protein IrtA

Gene

irtA

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity).By similarity

Cofactori

FADBy similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi643 – 650ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, FAD, Flavoprotein, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron import ATP-binding/permease protein IrtA (EC:3.6.3.-)
Alternative name(s):
Iron-regulated transporter A
Gene namesi
Name:irtA
Ordered Locus Names:MT1390
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 292CytoplasmicSequence analysisAdd BLAST292
Transmembranei293 – 313HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini314 – 334ExtracellularSequence analysisAdd BLAST21
Transmembranei335 – 355HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini356 – 408CytoplasmicSequence analysisAdd BLAST53
Transmembranei409 – 429HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini430 – 432ExtracellularSequence analysis3
Transmembranei433 – 453HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini454 – 519CytoplasmicSequence analysisAdd BLAST66
Transmembranei520 – 540HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini541 – 548ExtracellularSequence analysis8
Transmembranei549 – 569HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini570 – 859CytoplasmicSequence analysisAdd BLAST290

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004267631 – 859Iron import ATP-binding/permease protein IrtAAdd BLAST859

Interactioni

Subunit structurei

Forms a heterodimer with IrtB.By similarity

Structurei

3D structure databases

ProteinModelPortaliP9WQJ8.
SMRiP9WQJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 122FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST108
Domaini293 – 575ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST283
Domaini610 – 843ABC transporterPROSITE-ProRule annotationAdd BLAST234

Domaini

In IrtA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
The FAD-binding domain could function as a flavin/ferric reductase necessary to release iron from the siderophore complex, making it available for utilization.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK14698.
OrthoDBiPOG091H00DB.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013113. FAD-bd_9_SIP.
IPR017927. Fd_Rdtase_FAD-bd.
IPR027417. P-loop_NTPase.
IPR017938. Riboflavin_synthase-like_b-brl.
IPR007037. SIP.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF08021. FAD_binding_9. 1 hit.
PF04954. SIP. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF63380. SSF63380. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51384. FAD_FR. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WQJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGLQGVML RSFGARDHTA TVIETISIAP HFVRVRMVSP TLFQDAEAEP
60 70 80 90 100
AAWLRFWFPD PNGSNTEFQR AYTISEADPA AGRFAVDVVL HDPAGPASSW
110 120 130 140 150
ARTVKPGATI AVMSLMGSSR FDVPEEQPAG YLLIGDSASI PGMNGIIETV
160 170 180 190 200
PNDVPIEMYL EQHDDNDTLI PLAKHPRLRV RWVMRRDEKS LAEAIENRDW
210 220 230 240 250
SDWYAWATPE AAALKCVRVR LRDEFGFPKS EIHAQAYWNA GRAMGTHRAT
260 270 280 290 300
EPAATEPEVG AAPQPESAVP APARGSWRAQ AASRLLAPLK LPLVLSGVLA
310 320 330 340 350
ALVTLAQLAP FVLLVELSRL LVSGAGAHRL FTVGFAAVGL LGTGALLAAA
360 370 380 390 400
LTLWLHVIDA RFARALRLRL LSKLSRLPLG WFTSRGSGSI KKLVTDDTLA
410 420 430 440 450
LHYLVTHAVP DAVAAVVAPV GVLVYLFVVD WRVALVLFGP VLVYLTITSS
460 470 480 490 500
LTIQSGPRIV QAQRWAEKMN GEAGSYLEGQ PVIRVFGAAS SSFRRRLDEY
510 520 530 540 550
IGFLVAWQRP LAGKKTLMDL ATRPATFLWL IAATGTLLVA THRMDPVNLL
560 570 580 590 600
PFMFLGTTFG ARLLGIAYGL GGLRTGLLAA RHLQVTLDET ELAVREHPRE
610 620 630 640 650
PLDGEAPATV VFDHVTFGYR PGVPVIQDVS LTLRPGTVTA LVGPSGSGKS
660 670 680 690 700
TLATLLARFH DVERGAIRVG GQDIRSLAAD ELYTRVGFVL QEAQLVHGTA
710 720 730 740 750
AENIALAVPD APAEQVQVAA REAQIHDRVL RLPDGYDTVL GANSGLSGGE
760 770 780 790 800
RQRLTIARAI LGDTPVLILD EATAFADPES EYLVQQALNR LTRDRTVLVI
810 820 830 840 850
AHRLHTITRA DQIVVLDHGR IVERGTHEEL LAAGGRYCRL WDTGQGSRVA

VAAAQDGTR
Length:859
Mass (Da):92,966
Last modified:April 16, 2014 - v1
Checksum:i37D756CCB349C9BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK45654.1.
PIRiC70740.
RefSeqiWP_003406958.1. NZ_KK341227.1.

Genome annotation databases

EnsemblBacteriaiAAK45654; AAK45654; MT1390.
KEGGimtc:MT1390.
PATRICifig|83331.31.peg.1498.

Similar proteinsi

Entry informationi

Entry nameiIRTA_MYCTO
AccessioniPrimary (citable) accession number: P9WQJ8
Secondary accession number(s): L0T6D6, P63391, Q11018
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 7, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families