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Protein

Vitamin B12 transport ATP-binding protein BacA

Gene

bacA

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ABC transporter involved in uptake of vitamin B12 and related corrinoids. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Contributes to maintenance of chronic infections (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi460 – 467ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin B12 transport ATP-binding protein BacA
Gene namesi
Name:bacA
Ordered Locus Names:MT1867
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei68 – 88HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei121 – 141HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei213 – 233HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei249 – 269HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei332 – 352HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004267681 – 639Vitamin B12 transport ATP-binding protein BacAAdd BLAST639

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP9WQI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 393ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST327
Domaini427 – 639ABC transporterPROSITE-ProRule annotationAdd BLAST213

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02471.
OrthoDBiPOG091H0B0R.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 3 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WQI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPKLFKPSI DWSRAFPDSV YWVGKAWTIS AICVLAILVL LRYLTPWGRQ
60 70 80 90 100
FWRITRAYFV GPNSVRVWLM LGVLLLSVVL AVRLNVLFSY QGNDMYTALQ
110 120 130 140 150
KAFEGIASGD GTVKRSGVRG FWMSIGVFSV MAVLHVTRVM ADIYLTQRFI
160 170 180 190 200
IAWRVWLTHH LTQDWLDGRA YYRDLFIDET IDNPDQRIQQ DVDIFTAGAG
210 220 230 240 250
GTPNAPSNGT ASTLLFGAVQ SIISVISFTA ILWNLSGTLN IFGVSIPRAM
260 270 280 290 300
FWTVLVYVFV ATVISFIIGR PLIWLSFRNE KLNAAFRYAL VRLRDAAEAV
310 320 330 340 350
GFYRGERVEG TQLQRRFTPV IDNYRRYVRR SIAFNGWNLS VSQTIVPLPW
360 370 380 390 400
VIQAPRLFAG QIDFGDVGQT ATSFGNIHDS LSFFRNNYDA FASFRAAIIR
410 420 430 440 450
LHGLVDANEK GRALPAVLTR PSDDESVELN DIEVRTPAGD RLIDPLDVRL
460 470 480 490 500
DRGGSLVITG RSGAGKTTLL RSLAELWPYA SGTLHRPGGE NETMFLSQLP
510 520 530 540 550
YVPLGTLRDV VCYPNSAAAI PDATLRDTLT KVALAPLCDR LDEERDWAKV
560 570 580 590 600
LSPGEQQRVA FARILLTKPK AVFLDESTSA LDTGLEFALY QLLRSELPDC
610 620 630
IVISVSHRPA LERLHENQLE LLGGGQWRLA PVEAAPAEV
Length:639
Mass (Da):71,317
Last modified:April 16, 2014 - v1
Checksum:iDE85BBEEF42759A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK46140.1.
PIRiD70720.
RefSeqiWP_003900416.1. NZ_KK341227.1.

Genome annotation databases

EnsemblBacteriaiAAK46140; AAK46140; MT1867.
KEGGimtc:MT1867.
PATRICifig|83331.31.peg.2010.

Similar proteinsi

Entry informationi

Entry nameiBACA_MYCTO
AccessioniPrimary (citable) accession number: P9WQI8
Secondary accession number(s): L0TAH3, Q50614
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 25, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families