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Protein

Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD3

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

GO - Molecular functioni

GO - Biological processi

  • mycolic acid biosynthetic process Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5058-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (EC:6.4.1.2)
Short name:
ACCase beta chain
Gene namesi
Name:accD3
Ordered Locus Names:Rv0904c
ORF Names:MTCY31.32c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0904c.

Subcellular locationi

GO - Cellular componenti

  • acetyl-CoA carboxylase complex Source: InterPro
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Not essential for growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001997731 – 495Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST495

Proteomic databases

PaxDbiP9WQH9.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0904c.

Structurei

3D structure databases

ProteinModelPortaliP9WQH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 236CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST236
Domaini242 – 470CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 470CarboxyltransferasePROSITE-ProRule annotationAdd BLAST470

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated
Contains 1 CoA carboxyltransferase C-terminal domain.PROSITE-ProRule annotation
Contains 1 CoA carboxyltransferase N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105D8K. Bacteria.
COG0777. LUCA.
COG0825. LUCA.
KOiK01962.
K01963.
OMAiAVIACEF.
PhylomeDBiP9WQH9.

Family and domain databases

Gene3Di3.90.226.10. 2 hits.
InterProiIPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
[Graphical view]
PfamiPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiPS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P9WQH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRITTDQLR HAVLDRGSFV SWDSEPLAVP VADSYARELA AARAATGADE
60 70 80 90 100
SVQTGEGRVF GRRVAVVACE FDFLGGSIGV AAAERITAAV ERATAERLPL
110 120 130 140 150
LASPSSGGTR MQEGTVAFLQ MVKIAAAIQL HNQARLPYLV YLRHPTTGGV
160 170 180 190 200
FASWGSLGHL TVAEPGALIG FLGPRVYELL YGDPFPSGVQ TAENLRRHGI
210 220 230 240 250
IDGVVALDRL RPMLDRALTV LIDAPEPLPA PQTPAPVPDV PTWDSVVASR
260 270 280 290 300
RPDRPGVRQL LRHGATDRVL LSGTDQGEAA TTLLALARFG GQPTVVLGQQ
310 320 330 340 350
RAVGGGGSTV GPAALREARR GMALAAELCL PLVLVIDAAG PALSAAAEQG
360 370 380 390 400
GLAGQIAHCL AELVTLDTPT VSILLGQGSG GPALAMLPAD RVLAALHGWL
410 420 430 440 450
APLPPEGASA IVFRDTAHAA ELAAAQGIRS ADLLKSGIVD TIVPEYPDAA
460 470 480 490
DEPIEFALRL SNAIAAEVHA LRKIPAPERL ATRLQRYRRI GLPRD
Length:495
Mass (Da):51,772
Last modified:April 16, 2014 - v1
Checksum:i156C96E927FF950C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43652.1.
PIRiE70783.
RefSeqiNP_215419.1. NC_000962.3.
WP_003404691.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP43652; CCP43652; Rv0904c.
GeneIDi885279.
KEGGimtu:Rv0904c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43652.1.
PIRiE70783.
RefSeqiNP_215419.1. NC_000962.3.
WP_003404691.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP9WQH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0904c.

Proteomic databases

PaxDbiP9WQH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43652; CCP43652; Rv0904c.
GeneIDi885279.
KEGGimtu:Rv0904c.

Organism-specific databases

TubercuListiRv0904c.

Phylogenomic databases

eggNOGiENOG4105D8K. Bacteria.
COG0777. LUCA.
COG0825. LUCA.
KOiK01962.
K01963.
OMAiAVIACEF.
PhylomeDBiP9WQH9.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5058-MONOMER.

Family and domain databases

Gene3Di3.90.226.10. 2 hits.
InterProiIPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
[Graphical view]
PfamiPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiPS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACCD_MYCTU
AccessioniPrimary (citable) accession number: P9WQH9
Secondary accession number(s): L0T824, P63405, Q10561
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 2, 2016
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Was identified as a high-confidence drug target.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.