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Protein

Probable propionyl-CoA carboxylase beta chain 5

Gene

accD5

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable propionyl-CoA carboxylase beta chain 5 (accD5), Probable propionyl-CoA carboxylase beta chain 6 (accD6)
  2. no protein annotated in this organism
  3. Probable methylmalonyl-CoA mutase small subunit (mutA), Probable methylmalonyl-CoA mutase large subunit (mutB)
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

  • acetyl-CoA carboxylase activity Source: MTBBASE
  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • propionyl-CoA carboxylase activity Source: MTBBASE

GO - Biological processi

  • carbon fixation Source: MTBBASE
  • fatty acid catabolic process Source: GO_Central

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00945; UER00908.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable propionyl-CoA carboxylase beta chain 5 (EC:6.4.1.3)
Short name:
PCCase
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase
Gene namesi
Name:accD5
Synonyms:pccB
Ordered Locus Names:Rv3280
ORF Names:MTCY71.20
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3280.

Subcellular locationi

GO - Cellular componenti

  • acetyl-CoA carboxylase complex Source: MTBBASE
  • cell wall Source: MTBBASE
  • plasma membrane Source: MTBBASE
  • protein complex Source: MTBBASE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001997991 – 548Probable propionyl-CoA carboxylase beta chain 5Add BLAST548

Proteomic databases

PaxDbiP9WQH7.

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7151762,EBI-7151762

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

STRINGi83332.Rv3280.

Structurei

Secondary structure

1548
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 39Combined sources15
Helixi45 – 53Combined sources9
Helixi59 – 66Combined sources8
Beta strandi73 – 76Combined sources4
Helixi88 – 90Combined sources3
Turni94 – 97Combined sources4
Beta strandi98 – 105Combined sources8
Beta strandi108 – 115Combined sources8
Helixi120 – 122Combined sources3
Helixi126 – 142Combined sources17
Beta strandi146 – 150Combined sources5
Helixi157 – 161Combined sources5
Helixi162 – 176Combined sources15
Turni177 – 180Combined sources4
Beta strandi183 – 187Combined sources5
Beta strandi189 – 193Combined sources5
Helixi194 – 196Combined sources3
Helixi197 – 201Combined sources5
Beta strandi202 – 208Combined sources7
Turni209 – 211Combined sources3
Beta strandi213 – 217Combined sources5
Helixi219 – 226Combined sources8
Helixi232 – 236Combined sources5
Helixi238 – 243Combined sources6
Beta strandi249 – 254Combined sources6
Helixi255 – 266Combined sources12
Helixi289 – 291Combined sources3
Helixi295 – 299Combined sources5
Helixi300 – 302Combined sources3
Beta strandi306 – 309Combined sources4
Helixi315 – 321Combined sources7
Beta strandi322 – 324Combined sources3
Beta strandi327 – 330Combined sources4
Beta strandi337 – 344Combined sources8
Beta strandi347 – 354Combined sources8
Turni356 – 358Combined sources3
Helixi359 – 361Combined sources3
Helixi365 – 380Combined sources16
Beta strandi385 – 391Combined sources7
Helixi398 – 402Combined sources5
Helixi405 – 418Combined sources14
Beta strandi423 – 432Combined sources10
Helixi433 – 438Combined sources6
Helixi442 – 444Combined sources3
Beta strandi447 – 451Combined sources5
Beta strandi456 – 460Combined sources5
Helixi462 – 469Combined sources8
Turni470 – 475Combined sources6
Helixi476 – 478Combined sources3
Helixi485 – 499Combined sources15
Beta strandi500 – 502Combined sources3
Helixi503 – 507Combined sources5
Beta strandi510 – 514Combined sources5
Helixi517 – 519Combined sources3
Helixi520 – 530Combined sources11
Turni531 – 533Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A7SX-ray2.90A/B/C/D/E/F1-548[»]
2BZRX-ray2.20A/B/C/D/E/F1-548[»]
ProteinModelPortaliP9WQH7.
SMRiP9WQH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 281CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST257
Domaini295 – 541CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST247

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 541CarboxyltransferasePROSITE-ProRule annotationAdd BLAST517

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated

Phylogenomic databases

eggNOGiENOG4105D8K. Bacteria.
COG4799. LUCA.
KOiK01966.
OMAiGKLWVRE.
PhylomeDBiP9WQH7.

Family and domain databases

InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WQH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVTDRSAH SAERSTEHTI DIHTTAGKLA ELHKRREESL HPVGEDAVEK
60 70 80 90 100
VHAKGKLTAR ERIYALLDED SFVELDALAK HRSTNFNLGE KRPLGDGVVT
110 120 130 140 150
GYGTIDGRDV CIFSQDATVF GGSLGEVYGE KIVKVQELAI KTGRPLIGIN
160 170 180 190 200
DGAGARIQEG VVSLGLYSRI FRNNILASGV IPQISLIMGA AAGGHVYSPA
210 220 230 240 250
LTDFVIMVDQ TSQMFITGPD VIKTVTGEEV TMEELGGAHT HMAKSGTAHY
260 270 280 290 300
AASGEQDAFD YVRELLSYLP PNNSTDAPRY QAAAPTGPIE ENLTDEDLEL
310 320 330 340 350
DTLIPDSPNQ PYDMHEVITR LLDDEFLEIQ AGYAQNIVVG FGRIDGRPVG
360 370 380 390 400
IVANQPTHFA GCLDINASEK AARFVRTCDC FNIPIVMLVD VPGFLPGTDQ
410 420 430 440 450
EYNGIIRRGA KLLYAYGEAT VPKITVITRK AYGGAYCVMG SKDMGCDVNL
460 470 480 490 500
AWPTAQIAVM GASGAVGFVY RQQLAEAAAN GEDIDKLRLR LQQEYEDTLV
510 520 530 540
NPYVAAERGY VDAVIPPSHT RGYIGTALRL LERKIAQLPP KKHGNVPL
Length:548
Mass (Da):59,354
Last modified:April 16, 2014 - v1
Checksum:iA1C4C382ABBE3FAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46099.1.
PIRiA70980.
RefSeqiNP_217797.1. NC_000962.3.
WP_003417136.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP46099; CCP46099; Rv3280.
GeneIDi888725.
KEGGimtu:Rv3280.

Similar proteinsi

Entry informationi

Entry nameiPCC5_MYCTU
AccessioniPrimary (citable) accession number: P9WQH7
Secondary accession number(s): L0TF57, P96885
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 22, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families