Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable propionyl-CoA carboxylase beta chain 5

Gene

accD5

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable propionyl-CoA carboxylase beta chain 6 (accD6), Probable propionyl-CoA carboxylase beta chain 5 (accD5)
  2. no protein annotated in this organism
  3. Probable methylmalonyl-CoA mutase small subunit (mutA), Probable methylmalonyl-CoA mutase large subunit (mutB)
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00945; UER00908.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable propionyl-CoA carboxylase beta chain 5 (EC:6.4.1.3)
Short name:
PCCase
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase
Gene namesi
Name:accD5
Synonyms:pccB
Ordered Locus Names:MT3379.1
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004267741 – 548Probable propionyl-CoA carboxylase beta chain 5Add BLAST548

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.By similarity

Structurei

3D structure databases

SMRiP9WQH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 281CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST257
Domaini295 – 541CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST247

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 541CarboxyltransferasePROSITE-ProRule annotationAdd BLAST517

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated

Phylogenomic databases

KOiK01966.
OrthoDBiPOG091H00L6.

Family and domain databases

InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WQH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVTDRSAH SAERSTEHTI DIHTTAGKLA ELHKRREESL HPVGEDAVEK
60 70 80 90 100
VHAKGKLTAR ERIYALLDED SFVELDALAK HRSTNFNLGE KRPLGDGVVT
110 120 130 140 150
GYGTIDGRDV CIFSQDATVF GGSLGEVYGE KIVKVQELAI KTGRPLIGIN
160 170 180 190 200
DGAGARIQEG VVSLGLYSRI FRNNILASGV IPQISLIMGA AAGGHVYSPA
210 220 230 240 250
LTDFVIMVDQ TSQMFITGPD VIKTVTGEEV TMEELGGAHT HMAKSGTAHY
260 270 280 290 300
AASGEQDAFD YVRELLSYLP PNNSTDAPRY QAAAPTGPIE ENLTDEDLEL
310 320 330 340 350
DTLIPDSPNQ PYDMHEVITR LLDDEFLEIQ AGYAQNIVVG FGRIGGRPVG
360 370 380 390 400
IVANQPTHFA GCLDINASEK AARFVRTCDC FNIPIVMLVD VPGFLPGTDQ
410 420 430 440 450
EYNGIIRRGA KLLYAYGEAT VPKITVITRK AYGGAYCVMG SKDMGCDVNL
460 470 480 490 500
AWPTAQIAVM GASGAVGFVY RQQLAEAAAN GEDIDKLRLR LQQEYEDTLV
510 520 530 540
NPYVAAERGY VDAVIPPSHT RGYIGTALRL LERKIAQLPP KKHGNVPL
Length:548
Mass (Da):59,296
Last modified:April 16, 2014 - v1
Checksum:i8D0A51EE9AE09F52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK47722.1.
PIRiA70980.
RefSeqiWP_003917758.1. NZ_KK341227.1.

Genome annotation databases

EnsemblBacteriaiAAK47722; AAK47722; MT3379.1.
KEGGimtc:MT3379.1.
PATRICifig|83331.31.peg.3637.

Similar proteinsi

Entry informationi

Entry nameiPCC5_MYCTO
AccessioniPrimary (citable) accession number: P9WQH6
Secondary accession number(s): L0TF57, P96885
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 7, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families