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Protein

Probable propionyl-CoA carboxylase beta chain 6

Gene

accD6

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable propionyl-CoA carboxylase beta chain 5 (accD5), Probable propionyl-CoA carboxylase beta chain 6 (accD6)
  2. no protein annotated in this organism
  3. Probable methylmalonyl-CoA mutase small subunit (mutA), Probable methylmalonyl-CoA mutase large subunit (mutB)
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

  • acetyl-CoA carboxylase activity Source: MTBBASE
  • ATP binding Source: UniProtKB-KW
  • propionyl-CoA carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  • fatty acid elongation, saturated fatty acid Source: MTBBASE
  • growth Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6463-MONOMER.
UniPathwayiUPA00945; UER00908.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable propionyl-CoA carboxylase beta chain 6 (EC:6.4.1.3)
Short name:
PCCase
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase
Gene namesi
Name:accD6
Ordered Locus Names:Rv2247
ORF Names:MTCY427.28
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2247.

Subcellular locationi

GO - Cellular componenti

  • acetyl-CoA carboxylase complex Source: MTBBASE
  • cell wall Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001998002 – 473Probable propionyl-CoA carboxylase beta chain 6Add BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP9WQH5.

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.By similarity

Protein-protein interaction databases

STRINGi83332.Rv2247.

Structurei

Secondary structure

1473
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi18 – 25Combined sources8
Beta strandi32 – 35Combined sources4
Beta strandi39 – 49Combined sources11
Beta strandi52 – 59Combined sources8
Turni61 – 63Combined sources3
Helixi64 – 66Combined sources3
Helixi70 – 86Combined sources17
Beta strandi90 – 96Combined sources7
Helixi101 – 103Combined sources3
Helixi104 – 121Combined sources18
Turni122 – 124Combined sources3
Beta strandi127 – 136Combined sources10
Helixi137 – 140Combined sources4
Helixi141 – 145Combined sources5
Beta strandi146 – 151Combined sources6
Beta strandi156 – 160Combined sources5
Helixi162 – 169Combined sources8
Helixi175 – 179Combined sources5
Helixi181 – 186Combined sources6
Beta strandi192 – 194Combined sources3
Helixi198 – 213Combined sources16
Helixi220 – 225Combined sources6
Helixi230 – 233Combined sources4
Beta strandi236 – 240Combined sources5
Helixi245 – 251Combined sources7
Beta strandi259 – 262Combined sources4
Beta strandi269 – 276Combined sources8
Beta strandi279 – 286Combined sources8
Turni288 – 290Combined sources3
Helixi291 – 293Combined sources3
Helixi297 – 313Combined sources17
Beta strandi317 – 323Combined sources7
Helixi330 – 333Combined sources4
Helixi335 – 350Combined sources16
Beta strandi355 – 364Combined sources10
Helixi365 – 370Combined sources6
Helixi374 – 376Combined sources3
Beta strandi379 – 383Combined sources5
Beta strandi388 – 392Combined sources5
Helixi394 – 398Combined sources5
Helixi403 – 408Combined sources6
Helixi411 – 428Combined sources18
Helixi432 – 437Combined sources6
Helixi447 – 449Combined sources3
Helixi450 – 460Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L6WX-ray1.95A/B1-473[»]
ProteinModelPortaliP9WQH5.
SMRiP9WQH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 224CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST223
Domaini225 – 473CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST249

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 473CarboxyltransferasePROSITE-ProRule annotationAdd BLAST472

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated
Contains 1 CoA carboxyltransferase C-terminal domain.PROSITE-ProRule annotation
Contains 1 CoA carboxyltransferase N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4106H22. Bacteria.
COG4799. LUCA.
KOiK18472.
OMAiAMGVDGC.
PhylomeDBiP9WQH5.

Family and domain databases

Gene3Di3.90.226.10. 2 hits.
InterProiIPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
[Graphical view]
PfamiPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiPS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P9WQH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIMAPEAVG ESLDPRDPLL RLSNFFDDGS VELLHERDRS GVLAAAGTVN
60 70 80 90 100
GVRTIAFCTD GTVMGGAMGV EGCTHIVNAY DTAIEDQSPI VGIWHSGGAR
110 120 130 140 150
LAEGVRALHA VGQVFEAMIR ASGYIPQISV VVGFAAGGAA YGPALTDVVV
160 170 180 190 200
MAPESRVFVT GPDVVRSVTG EDVDMASLGG PETHHKKSGV CHIVADDELD
210 220 230 240 250
AYDRGRRLVG LFCQQGHFDR SKAEAGDTDI HALLPESSRR AYDVRPIVTA
260 270 280 290 300
ILDADTPFDE FQANWAPSMV VGLGRLSGRT VGVLANNPLR LGGCLNSESA
310 320 330 340 350
EKAARFVRLC DAFGIPLVVV VDVPGYLPGV DQEWGGVVRR GAKLLHAFGE
360 370 380 390 400
CTVPRVTLVT RKTYGGAYIA MNSRSLNATK VFAWPDAEVA VMGAKAAVGI
410 420 430 440 450
LHKKKLAAAP EHEREALHDQ LAAEHERIAG GVDSALDIGV VDEKIDPAHT
460 470
RSKLTEALAQ APARRGRHKN IPL
Length:473
Mass (Da):50,136
Last modified:April 16, 2014 - v1
Checksum:i94AD7EBD88F233C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45027.1.
PIRiC70779.
RefSeqiNP_216763.1. NC_000962.3.
WP_003900487.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP45027; CCP45027; Rv2247.
GeneIDi887671.
KEGGimtu:Rv2247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45027.1.
PIRiC70779.
RefSeqiNP_216763.1. NC_000962.3.
WP_003900487.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L6WX-ray1.95A/B1-473[»]
ProteinModelPortaliP9WQH5.
SMRiP9WQH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2247.

Proteomic databases

PaxDbiP9WQH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP45027; CCP45027; Rv2247.
GeneIDi887671.
KEGGimtu:Rv2247.

Organism-specific databases

TubercuListiRv2247.

Phylogenomic databases

eggNOGiENOG4106H22. Bacteria.
COG4799. LUCA.
KOiK18472.
OMAiAMGVDGC.
PhylomeDBiP9WQH5.

Enzyme and pathway databases

UniPathwayiUPA00945; UER00908.
BioCyciMTBH37RV:G185E-6463-MONOMER.

Family and domain databases

Gene3Di3.90.226.10. 2 hits.
InterProiIPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
[Graphical view]
PfamiPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiPS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCC6_MYCTU
AccessioniPrimary (citable) accession number: P9WQH5
Secondary accession number(s): L0TBQ7, P63407, Q10506
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 2, 2016
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.