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Protein

Probable propionyl-CoA carboxylase beta chain 6

Gene

accD6

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable propionyl-CoA carboxylase beta chain 6 (accD6), Probable propionyl-CoA carboxylase beta chain 5 (accD5)
  2. no protein annotated in this organism
  3. Probable methylmalonyl-CoA mutase small subunit (mutA), Probable methylmalonyl-CoA mutase large subunit (mutB)
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00945; UER00908.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable propionyl-CoA carboxylase beta chain 6 (EC:6.4.1.3)
Short name:
PCCase
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase
Gene namesi
Name:accD6
Ordered Locus Names:MT2307
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004267751 – 473Probable propionyl-CoA carboxylase beta chain 6Add BLAST473

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.By similarity

Structurei

Secondary structure

1473
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 16Combined sources3
Helixi18 – 25Combined sources8
Beta strandi32 – 35Combined sources4
Beta strandi39 – 49Combined sources11
Beta strandi52 – 59Combined sources8
Turni61 – 63Combined sources3
Helixi64 – 66Combined sources3
Helixi70 – 86Combined sources17
Beta strandi90 – 96Combined sources7
Helixi101 – 104Combined sources4
Helixi105 – 121Combined sources17
Turni122 – 124Combined sources3
Beta strandi127 – 136Combined sources10
Helixi138 – 144Combined sources7
Beta strandi146 – 151Combined sources6
Beta strandi156 – 159Combined sources4
Beta strandi177 – 179Combined sources3
Turni181 – 184Combined sources4
Helixi185 – 187Combined sources3
Beta strandi188 – 190Combined sources3
Beta strandi192 – 194Combined sources3
Helixi198 – 213Combined sources16
Helixi220 – 225Combined sources6
Helixi230 – 233Combined sources4
Helixi245 – 251Combined sources7
Beta strandi259 – 262Combined sources4
Beta strandi269 – 276Combined sources8
Beta strandi279 – 286Combined sources8
Turni288 – 290Combined sources3
Helixi291 – 293Combined sources3
Turni297 – 299Combined sources3
Helixi303 – 313Combined sources11
Beta strandi317 – 323Combined sources7
Helixi335 – 350Combined sources16
Beta strandi355 – 364Combined sources10
Helixi365 – 370Combined sources6
Helixi374 – 376Combined sources3
Beta strandi379 – 383Combined sources5
Beta strandi388 – 392Combined sources5
Helixi394 – 401Combined sources8
Helixi403 – 408Combined sources6
Helixi411 – 428Combined sources18
Beta strandi429 – 431Combined sources3
Helixi432 – 438Combined sources7
Helixi447 – 449Combined sources3
Helixi450 – 460Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FB8X-ray3.00A/B1-473[»]
4G2RX-ray2.28A/B1-473[»]
ProteinModelPortaliP9WQH4.
SMRiP9WQH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 224CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST224
Domaini225 – 473CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST249

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 473CarboxyltransferasePROSITE-ProRule annotationAdd BLAST473

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated

Phylogenomic databases

KOiK18472.
OrthoDBiPOG091H00L6.

Family and domain databases

InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WQH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIMAPEAVG ESLDPRDPLL RLSNFFDDGS VELLHERDRS GVLAAAGTVN
60 70 80 90 100
GVRTIAFCTD GTVMGGAMGV EGCTHIVNAY DTAIEDQSPI VGIWHSGGAR
110 120 130 140 150
LAEGVRALHA VGQVFEAMIR ASGYIPQISV VVGFAAGGAA YGPALTDVVV
160 170 180 190 200
MAPESRVFVT GPDVVRSVTG EDVDMASLGG PETHHKKSGV CHIVADDELD
210 220 230 240 250
AYDRGRRLVG LFCQQGHFDR SKAEAGDTDI HALLPESSRR AYDVRPIVTA
260 270 280 290 300
ILDADTPFDE FQANWAPSMV VGLGRLSGRT VGVLANNPLR LGGCLNSESA
310 320 330 340 350
EKAARFVRLC DAFGIPLVVV VDVPGYLPGV DQEWGGVVRR GAKLLHAFGE
360 370 380 390 400
CTVPRVTLVT RKTYGGAYIA MNSRSLNATK VFAWPDAEVA VMGAKAAVGI
410 420 430 440 450
LHKKKLAAAP EHEREALHDQ LAAEHERIAG GVDSALDIGV VDEKIDPAHT
460 470
RSKLTEALAQ APARRGRHKN IPL
Length:473
Mass (Da):50,136
Last modified:April 16, 2014 - v1
Checksum:i94AD7EBD88F233C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK46591.1.
PIRiC70779.
RefSeqiWP_003900487.1. NZ_KK341227.1.

Genome annotation databases

EnsemblBacteriaiAAK46591; AAK46591; MT2307.
KEGGimtc:MT2307.
PATRICifig|83331.31.peg.2484.

Similar proteinsi

Entry informationi

Entry nameiPCC6_MYCTO
AccessioniPrimary (citable) accession number: P9WQH4
Secondary accession number(s): L0TBQ7, P63407, Q10506
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 7, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families