Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetaldehyde dehydrogenase

Gene

mhpF

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127Acyl-thioester intermediateUniRule annotation1
Binding sitei277NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi158 – 166NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:G185E-7812-MONOMER.
MTBH37RV:G185E-7812-MONOMER.

Chemistry databases

SwissLipidsiSLP:000001172.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:Rv3535c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3535c.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876881 – 303Acetaldehyde dehydrogenaseAdd BLAST303

Proteomic databases

PaxDbiP9WQH3.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3535c.

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 10Combined sources6
Helixi14 – 24Combined sources11
Beta strandi27 – 35Combined sources9
Helixi42 – 49Combined sources8
Beta strandi53 – 57Combined sources5
Helixi59 – 62Combined sources4
Beta strandi70 – 74Combined sources5
Helixi78 – 91Combined sources14
Beta strandi94 – 97Combined sources4
Helixi109 – 116Combined sources8
Beta strandi120 – 123Combined sources4
Helixi127 – 140Combined sources14
Beta strandi148 – 155Combined sources8
Helixi156 – 158Combined sources3
Helixi161 – 165Combined sources5
Helixi167 – 180Combined sources14
Beta strandi185 – 194Combined sources10
Beta strandi202 – 210Combined sources9
Helixi216 – 231Combined sources16
Beta strandi237 – 241Combined sources5
Beta strandi244 – 246Combined sources3
Turni250 – 254Combined sources5
Beta strandi256 – 264Combined sources9
Beta strandi269 – 271Combined sources3
Helixi276 – 295Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JN6X-ray1.93B/D1-303[»]
ProteinModelPortaliP9WQH3.
SMRiP9WQH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV. Bacteria.
COG4569. LUCA.
KOiK04073.
OMAiQGNVNMV.
PhylomeDBiP9WQH3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WQH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKAKVAIV GSGNISTDLL YKLLRSEWLE PRWMVGIDPE SDGLARAAKL
60 70 80 90 100
GLETTHEGVD WLLAQPDKPD LVFEATSAYV HRDAAPKYAE AGIRAIDLTP
110 120 130 140 150
AAVGPAVIPP ANLREHLDAP NVNMITCGGQ ATIPIVYAVS RIVEVPYAEI
160 170 180 190 200
VASVASVSAG PGTRANIDEF TKTTARGVQT IGGAARGKAI IILNPADPPM
210 220 230 240 250
IMRDTIFCAI PTDADREAIA ASIHDVVKEV QTYVPGYRLL NEPQFDEPSI
260 270 280 290 300
NSGGQALVTT FVEVEGAGDY LPPYAGNLDI MTAAATKVGE EIAKETLVVG

GAR
Length:303
Mass (Da):32,009
Last modified:April 16, 2014 - v1
Checksum:iD52F1BEA88A56827
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46357.1.
PIRiH70675.
RefSeqiNP_218052.1. NC_000962.3.
WP_003419251.1. NZ_KK339374.1.

Genome annotation databases

EnsemblBacteriaiCCP46357; CCP46357; Rv3535c.
GeneIDi888396.
KEGGimtu:Rv3535c.
mtv:RVBD_3535c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46357.1.
PIRiH70675.
RefSeqiNP_218052.1. NC_000962.3.
WP_003419251.1. NZ_KK339374.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JN6X-ray1.93B/D1-303[»]
ProteinModelPortaliP9WQH3.
SMRiP9WQH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3535c.

Chemistry databases

SwissLipidsiSLP:000001172.

Proteomic databases

PaxDbiP9WQH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP46357; CCP46357; Rv3535c.
GeneIDi888396.
KEGGimtu:Rv3535c.
mtv:RVBD_3535c.

Organism-specific databases

TubercuListiRv3535c.

Phylogenomic databases

eggNOGiENOG4105DIV. Bacteria.
COG4569. LUCA.
KOiK04073.
OMAiQGNVNMV.
PhylomeDBiP9WQH3.

Enzyme and pathway databases

BioCyciMetaCyc:G185E-7812-MONOMER.
MTBH37RV:G185E-7812-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACDH_MYCTU
AccessioniPrimary (citable) accession number: P9WQH3
Secondary accession number(s): L0TEF0, P71866, Q7D5C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 2, 2016
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.