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Protein

Alcohol dehydrogenase B

Gene

adhB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc 1; catalyticBy similarity1
Metal bindingi62Zinc 1; catalyticBy similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi169Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase B (EC:1.1.1.1)
Gene namesi
Name:adhB
Ordered Locus Names:Rv0761c
ORF Names:MTCY369.06c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0761c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: MTBBASE

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607431 – 375Alcohol dehydrogenase BAdd BLAST375

Proteomic databases

PaxDbiP9WQC7.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0761c.

Structurei

3D structure databases

ProteinModelPortaliP9WQC7.
SMRiP9WQC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG41088XM. Bacteria.
COG1062. LUCA.
KOiK00121.
OMAiECTSCLN.
PhylomeDBiP9WQC7.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR023921. ADH_Zn_actinomycetes.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03989. Rxyl_3153. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WQC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKGALIWE FNQPWSVEEI EIGDPRKDEV KIQMEAAGMC RSDHHLVTGD
60 70 80 90 100
IPMAGFPVLG GHEGAGIVTE VGPGVDDFAP GDHVVLAFIP SCGKCPSCQA
110 120 130 140 150
GMRNLCDLGA GLLAGESVTD GSFRIQARGQ NVYPMTLLGT FSPYMVVHRS
160 170 180 190 200
SVVKIDPSVP FEVACLVGCG VTTGYGSAVR TADVRPGDDV AIVGLGGVGM
210 220 230 240 250
AALQGAVSAG ARYVFAVEPV EWKRDQALKF GATHVYPDIN AALMGIAEVT
260 270 280 290 300
YGLMAQKVII TVGKLDGADV DSYLTITAKG GTCVLTAIGS LVDTQVTLNL
310 320 330 340 350
AMLTLLQKNI QGTIFGGGNP HYDIPKLLSM YKAGKLNLDD MVTTAYKLEQ
360 370
INDGYQDMLN GKNIRGVIRY TDDDR
Length:375
Mass (Da):39,748
Last modified:April 16, 2014 - v1
Checksum:i8DBF5D1504EECDE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43508.1.
PIRiD70706.
RefSeqiWP_003403885.1. NZ_KK339370.1.
YP_177754.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP43508; CCP43508; Rv0761c.
GeneIDi888738.
KEGGimtu:Rv0761c.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADHB_MYCTU
AccessioniPrimary (citable) accession number: P9WQC7
Secondary accession number(s): L0T7F0, P71818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 7, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families