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Protein

Probable alcohol dehydrogenase adh

Gene

adh

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43Zinc 1; catalyticBy similarity1
Metal bindingi64Zinc 1; catalyticBy similarity1
Metal bindingi97Zinc 2By similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi111Zinc 2By similarity1
Metal bindingi163Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alcohol dehydrogenase adh (EC:1.1.1.1)
Gene namesi
Name:adh
Ordered Locus Names:Rv1530
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003913401 – 367Probable alcohol dehydrogenase adhAdd BLAST367

Proteomic databases

PaxDbiP9WQC3.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1530.

Structurei

3D structure databases

ProteinModelPortaliP9WQC3.
SMRiP9WQC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1063. LUCA.
KOiK00001.
OMAiVEYPAYR.
PhylomeDBiP9WQC3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WQC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGAVVRAL VLEAPRRLVV RQYRLPRIGD DDALVRVEAC GLCGTDHEQY
60 70 80 90 100
TGELAGGFAF VPGHETVGTI AAIGPRAEQR WGVSAGDRVA VEVFQSCRQC
110 120 130 140 150
ANCRGGEYRR CVRHGLADMY GFIPVDREPG LWGGYAEYQY LAPDSMVLRV
160 170 180 190 200
AGDLSPEVAT LFNPLGAGIR WGVTIPETKP GDVVAVLGPG IRGLCAAAAA
210 220 230 240 250
KGAGAGFVMV TGLGPRDADR LALAAQFGAD LAVDVAIDDP VAALTEQTGG
260 270 280 290 300
LADVVVDVTA KAPAAFAQAI ALARPAGTVV VAGTRGVGSG APGFSPDVVV
310 320 330 340 350
FKELRVLGAL GVDATAYRAA LDLLVSGRYP FASLPRRCVR LEGAEDLLAT
360
MAGERDGVPP IHGVLTP
Length:367
Mass (Da):37,997
Last modified:April 16, 2014 - v1
Checksum:iCE6FC6E7C33EFA2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44294.1.
PIRiC70820.
RefSeqiNP_216046.1. NC_000962.3.
WP_003407690.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44294; CCP44294; Rv1530.
GeneIDi886426.
KEGGimtu:Rv1530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44294.1.
PIRiC70820.
RefSeqiNP_216046.1. NC_000962.3.
WP_003407690.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP9WQC3.
SMRiP9WQC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1530.

Proteomic databases

PaxDbiP9WQC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44294; CCP44294; Rv1530.
GeneIDi886426.
KEGGimtu:Rv1530.

Organism-specific databases

TubercuListiRv1530.

Phylogenomic databases

eggNOGiCOG1063. LUCA.
KOiK00001.
OMAiVEYPAYR.
PhylomeDBiP9WQC3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_MYCTU
AccessioniPrimary (citable) accession number: P9WQC3
Secondary accession number(s): L0T9P8, O53904, Q7D8B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: February 15, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Was identified as a high-confidence drug target.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.