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Protein

Probable alcohol dehydrogenase AdhA

Gene

adhA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Zinc 1; catalyticBy similarity1
Metal bindingi73Zinc 1; catalyticBy similarity1
Metal bindingi109Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi123Zinc 2By similarity1
Metal bindingi165Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alcohol dehydrogenase AdhA (EC:1.1.1.1)
Gene namesi
Name:adhA
Ordered Locus Names:Rv1862
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003913412 – 346Probable alcohol dehydrogenase AdhAAdd BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP9WQC1.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1862.

Structurei

3D structure databases

ProteinModelPortaliP9WQC1.
SMRiP9WQC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DQ4. Bacteria.
COG1064. LUCA.
KOiK13953.
OMAiWAGASHE.
PhylomeDBiP9WQC1.

Family and domain databases

CDDicd08298. CAD2. 1 hit.
Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR014187. ADH_Zn_typ-2.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02822. adh_fam_2. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P9WQC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSPATTATM SAWQVRRPGP MDTGPLERVT TRVPRPAPSE LLVAVHACGV
60 70 80 90 100
CRTDLHVTEG DLPVHRERVI PGHEVVGEVI EVGSAVGAAA GGEFDRGDRV
110 120 130 140 150
GIAWLRHTCG VCKYCRRGSE NLCPQSRYTG WDADGGYAEF TTVPAAFAHH
160 170 180 190 200
LPSGYSDSEL APLLCAGIIG YRSLLRTELP PGGRLGLYGF GGSAHITAQV
210 220 230 240 250
ALAQGAEIHV MTRGARARKL ALQLGAASAQ DAADRPPVPL DAAILFAPVG
260 270 280 290 300
DLVLPALEAL DRGGILAIAG IHLTDIPDLN YQQHLFQERQ IRSVTSNTRA
310 320 330 340
DARAFFDFAA QHHIEVTTPE YPLGQADRAL GDLSAGRIAG AAVLLI
Length:346
Mass (Da):36,632
Last modified:April 16, 2014 - v1
Checksum:i107AD0EF4256812C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44628.1.
PIRiF70666.
RefSeqiNP_216378.1. NC_000962.3.
WP_003409345.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44628; CCP44628; Rv1862.
GeneIDi885652.
KEGGimtu:Rv1862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44628.1.
PIRiF70666.
RefSeqiNP_216378.1. NC_000962.3.
WP_003409345.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP9WQC1.
SMRiP9WQC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1862.

Proteomic databases

PaxDbiP9WQC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44628; CCP44628; Rv1862.
GeneIDi885652.
KEGGimtu:Rv1862.

Organism-specific databases

TubercuListiRv1862.

Phylogenomic databases

eggNOGiENOG4105DQ4. Bacteria.
COG1064. LUCA.
KOiK13953.
OMAiWAGASHE.
PhylomeDBiP9WQC1.

Family and domain databases

CDDicd08298. CAD2. 1 hit.
Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR014187. ADH_Zn_typ-2.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02822. adh_fam_2. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADHA_MYCTU
AccessioniPrimary (citable) accession number: P9WQC1
Secondary accession number(s): L0T838, P95153, Q7D7W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: February 15, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Was identified as a high-confidence drug target.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.