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Protein

Probable alcohol dehydrogenase AdhA

Gene

adhA

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Zinc 1; catalyticBy similarity1
Metal bindingi73Zinc 1; catalyticBy similarity1
Metal bindingi109Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi123Zinc 2By similarity1
Metal bindingi165Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alcohol dehydrogenase AdhA (EC:1.1.1.1)
Gene namesi
Name:adhA
Ordered Locus Names:MT1911
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004268021 – 346Probable alcohol dehydrogenase AdhAAdd BLAST346

Proteomic databases

PRIDEiP9WQC0

Structurei

3D structure databases

ProteinModelPortaliP9WQC0
SMRiP9WQC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK13953
OrthoDBiPOG091H07QD

Family and domain databases

CDDicd08298 CAD2, 1 hit
InterProiView protein in InterPro
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR014187 ADH_Zn_typ-2
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02822 adh_fam_2, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P9WQC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSPATTATM SAWQVRRPGP MDTGPLERVT TRVPRPAPSE LLVAVHACGV
60 70 80 90 100
CRTDLHVTEG DLPVHRERVI PGHEVVGEVI EVGSAVGAAA GGEFDRGDRV
110 120 130 140 150
GIAWLRHTCG VCKYCRRGSE NLCPQSRYTG WDADGGYAEF TTVPAAFAHH
160 170 180 190 200
LPSGYSDSEL APLLCAGIIG YRSLLRTELP PGGRLGLYGF GGSAHITAQV
210 220 230 240 250
ALAQGAEIHV MTRGARARKL ALQLGAASAQ DAADRPPVPL DAAILFAPVG
260 270 280 290 300
DLVLPALEAL DRGGILAIAG IHLTDIPDLN YQQHLFQERQ IRSVTSNTRA
310 320 330 340
DARAFFDFAA QHHIEVTTPE YPLGQADRAL GDLSAGRIAG AAVLLI
Length:346
Mass (Da):36,632
Last modified:April 16, 2014 - v1
Checksum:i107AD0EF4256812C
GO

Sequence cautioni

The sequence AAK46182 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA Translation: AAK46182.1 Different initiation.
PIRiF70666
RefSeqiWP_003409345.1, NZ_KK341227.1

Genome annotation databases

EnsemblBacteriaiAAK46182; AAK46182; MT1911
KEGGimtc:MT1911
PATRICifig|83331.31.peg.2056

Similar proteinsi

Entry informationi

Entry nameiADHA_MYCTO
AccessioniPrimary (citable) accession number: P9WQC0
Secondary accession number(s): L0T838, P95153, Q7D7W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: May 23, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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