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Protein

Putative alcohol dehydrogenase D

Gene

adhD

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH.1 Publication

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc 1; catalyticBy similarity1
Metal bindingi61Zinc 1; catalyticBy similarity1
Metal bindingi91Zinc 2By similarity1
Metal bindingi94Zinc 2By similarity1
Metal bindingi97Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi167Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • growth of symbiont in host cell Source: MTBBASE
  • response to acidic pH Source: MTBBASE

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative alcohol dehydrogenase D (EC:1.1.1.1)
Gene namesi
Name:adhD
Ordered Locus Names:Rv3086
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3086

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE

Pathology & Biotechi

Disruption phenotypei

Inactivation of the mymA operon causes altered cell wall structure, reduced contents and altered composition of mycolic acids along with the accumulation of saturated C24 and C26 fatty acids, and enhanced susceptibility to antibiotics, detergents and acidic pH. Also impairs ability to survive in macrophages.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004208791 – 368Putative alcohol dehydrogenase DAdd BLAST368

Proteomic databases

PaxDbiP9WQB9

Expressioni

Inductioni

Expression is controlled by VirS. Induced at acidic pH and in macrophages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3086

Structurei

3D structure databases

ProteinModelPortaliP9WQB9
SMRiP9WQB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1062 LUCA
KOiK00121
OMAiGEVLIKY
PhylomeDBiP9WQB9

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR023921 ADH_Zn_actinomycetes
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03989 Rxyl_3153, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P9WQB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTTAAVLFE AGKPFELMEL DLDGPGPGEV LVKYTAAGLC HSDLHLTDGD
60 70 80 90 100
LPPRFPIVGG HEGSGVIEEV GAGVTRVKPG DHVVCSFIPN CGTCRYCCTG
110 120 130 140 150
RQNLCDMGAT ILEGCMPDGS FRFHSQGTDF GAMCMLGTFA ERATVSQHSV
160 170 180 190 200
VKVDDWLPLE TAVLVGCGVP SGWGTAVNAG NLRAGDTAVI YGVGGLGINA
210 220 230 240 250
VQGATAAGCK YVVVVDPVAF KRETALKFGA THAFADAASA AAKVDELTWG
260 270 280 290 300
QGADAALILV GTVDDEVVSA ATAVIGKGGT VVITGLADPA KLTVHVSGTD
310 320 330 340 350
LTLHEKTIKG SLFGSCNPQY DIVRLLRLYD AGQLMLDELV TTTYNLEQVN
360
QGYQDLRDGK NIRGVIVH
Length:368
Mass (Da):38,342
Last modified:April 16, 2014 - v1
Checksum:iA03FCB6F3C8003AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP45895.1
PIRiB70853
RefSeqiNP_217602.1, NC_000962.3
WP_003416075.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP45895; CCP45895; Rv3086
GeneIDi888654
KEGGimtu:Rv3086

Similar proteinsi

Entry informationi

Entry nameiADHD_MYCTU
AccessioniPrimary (citable) accession number: P9WQB9
Secondary accession number(s): F2GNY2
, L0TD46, O53303, Q7D655
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: March 28, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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