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P9WQ79

- GABT_MYCTU

UniProt

P9WQ79 - GABT_MYCTU

Protein

4-aminobutyrate aminotransferase

Gene

gabT

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 6 (01 Oct 2014)
      Sequence version 1 (16 Apr 2014)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
    (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. (S)-3-amino-2-methylpropionate transaminase activity Source: UniProtKB-EC
    2. 4-aminobutyrate transaminase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. gamma-aminobutyric acid catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00733.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-aminobutyrate aminotransferase (EC:2.6.1.19)
    Alternative name(s):
    (S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
    GABA aminotransferase
    Short name:
    GABA-AT
    Gamma-amino-N-butyrate transaminase
    Short name:
    GABA transaminase
    Glutamate:succinic semialdehyde transaminase
    L-AIBAT
    Gene namesi
    Name:gabT
    Ordered Locus Names:Rv2589
    ORF Names:MTCY227.12c
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001584: Chromosome

    Organism-specific databases

    TubercuListiRv2589.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: MTBBASE

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4494494-aminobutyrate aminotransferasePRO_0000120386Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei294 – 2941N6-(pyridoxal phosphate)lysineBy similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP9WQ79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK07250.
    PhylomeDBiP9WQ79.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004632. 4NH2But_aminotransferase_bac.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00700. GABAtrnsam. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P9WQ79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASLQQSRRL VTEIPGPASQ ALTHRRAAAV SSGVGVTLPV FVARAGGGIV    50
    EDVDGNRLID LGSGIAVTTI GNSSPRVVDA VRTQVAEFTH TCFMVTPYEG 100
    YVAVAEQLNR ITPGSGPKRS VLFNSGAEAV ENAVKIARSY TGKPAVVAFD 150
    HAYHGRTNLT MALTAKSMPY KSGFGPFAPE IYRAPLSYPY RDGLLDKQLA 200
    TNGELAAARA IGVIDKQVGA NNLAALVIEP IQGEGGFIVP AEGFLPALLD 250
    WCRKNHVVFI ADEVQTGFAR TGAMFACEHE GPDGLEPDLI CTAKGIADGL 300
    PLSAVTGRAE IMNAPHVGGL GGTFGGNPVA CAAALATIAT IESDGLIERA 350
    RQIERLVTDR LTTLQAVDDR IGDVRGRGAM IAVELVKSGT TEPDAGLTER 400
    LATAAHAAGV IILTCGMFGN IIRLLPPLTI GDELLSEGLD IVCAILADL 449
    Length:449
    Mass (Da):46,813
    Last modified:April 16, 2014 - v1
    Checksum:i9EB88A968B3D8719
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP45385.1.
    PIRiD70726.
    RefSeqiNP_217105.1. NC_000962.3.
    YP_006516030.1. NC_018143.2.

    Genome annotation databases

    GeneIDi13319309.
    887915.
    KEGGimtu:Rv2589.
    mtv:RVBD_2589.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP45385.1 .
    PIRi D70726.
    RefSeqi NP_217105.1. NC_000962.3.
    YP_006516030.1. NC_018143.2.

    3D structure databases

    ProteinModelPortali P9WQ79.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 13319309.
    887915.
    KEGGi mtu:Rv2589.
    mtv:RVBD_2589.

    Organism-specific databases

    TubercuListi Rv2589.

    Phylogenomic databases

    KOi K07250.
    PhylomeDBi P9WQ79.

    Enzyme and pathway databases

    UniPathwayi UPA00733 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004632. 4NH2But_aminotransferase_bac.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00700. GABAtrnsam. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37Rv.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ATCC 25618 / H37Rv.

    Entry informationi

    Entry nameiGABT_MYCTU
    AccessioniPrimary (citable) accession number: P9WQ79
    Secondary accession number(s): L0TA45, P63504, Q50632
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2014
    Last sequence update: April 16, 2014
    Last modified: October 1, 2014
    This is version 6 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
      Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3