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Protein

Probable long-chain-fatty-acid--CoA ligase FadD23

Gene

fadD23

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension (Probable). Involved in the biosynthesis of sulfolipid 1 (SL-1).Curated1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • Actinobacterium-type cell wall biogenesis Source: UniProtKB
  • fatty acid biosynthetic process Source: GO_Central
  • sulfolipid biosynthetic process Source: MTBBASE

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:G185E-8122-MONOMER
UniPathwayiUPA00094

Chemistry databases

SwissLipidsiSLP:000000984

Names & Taxonomyi

Protein namesi
Recommended name:
Probable long-chain-fatty-acid--CoA ligase FadD23 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD23
Ordered Locus Names:Rv3826
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3826

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Disruption of fadD23 increases binding affinity to human macrophage-like cell THP-1 and shows a lack of sulfolipid 1 production as compared to wild-type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004067931 – 584Probable long-chain-fatty-acid--CoA ligase FadD23Add BLAST584

Proteomic databases

PaxDbiP9WQ47
PRIDEiP9WQ47

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3826

Structurei

3D structure databases

ProteinModelPortaliP9WQ47
SMRiP9WQ47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RCI Bacteria
COG0318 LUCA
KOiK12425
OMAiSEYRATH
PhylomeDBiP9WQ47

Family and domain databases

InterProiView protein in InterPro
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit

Sequencei

Sequence statusi: Complete.

P9WQ47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLSIPSML RQCVNLHPDG TAFTYIDYER DSEGISESLT WSQVYRRTLN
60 70 80 90 100
VAAEVRRHAA IGDRAVILAP QGLDYIVAFL GALQAGLIAV PLSAPLGGAS
110 120 130 140 150
DERVDAVVRD AKPNVVLTTS AIMGDVVPRV TPPPGIASPP TVAVDQLDLD
160 170 180 190 200
SPIRSNIVDD SLQTTAYLQY TSGSTRTPAG VMITYKNILA NFQQMISAYF
210 220 230 240 250
ADTGAVPPLD LFIMSWLPFY HDMGLVLGVC APIIVGCGAV LTSPVAFLQR
260 270 280 290 300
PARWLQLMAR EGQAFSAAPN FAFELTAAKA IDDDLAGLDL GRIKTILCGS
310 320 330 340 350
ERVHPATLKR FVDRFSRFNL REFAIRPAYG LAEATVYVAT SQAGQPPEIR
360 370 380 390 400
YFEPHELSAG QAKPCATGAG TALVSYPLPQ SPIVRIVDPN TNTECPPGTI
410 420 430 440 450
GEIWVHGDNV AGGYWEKPDE TERTFGGALV APSAGTPVGP WLRTGDSGFV
460 470 480 490 500
SEDKFFIIGR IKDLLIVYGR NHSPDDIEAT IQEITRGRCA AIAVPSNGVE
510 520 530 540 550
KLVAIVELNN RGNLDTERLS FVTREVTSAI STSHGLSVSD LVLVAPGSIP
560 570 580
ITTSGKVRRA ECVKLYRHNE FTRLDAKPLQ ASDL
Length:584
Mass (Da):62,841
Last modified:April 16, 2014 - v1
Checksum:i99639AB9BEEA39EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46655.1
PIRiF70522
RefSeqiNP_218343.1, NC_000962.3
WP_003899713.1, NZ_KK339374.1

Genome annotation databases

EnsemblBacteriaiCCP46655; CCP46655; Rv3826
GeneIDi886154
KEGGimtu:Rv3826

Similar proteinsi

Entry informationi

Entry nameiFAC23_MYCTU
AccessioniPrimary (citable) accession number: P9WQ47
Secondary accession number(s): L0TGV3, O07797, Q7D4S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: May 23, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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