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Protein

Uncharacterized protein Rv1318c

Gene

Rv1318c

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • adenylate cyclase activity Source: MTBBASE
  • signal transducer activity Source: InterPro

GO - Biological processi

  • cAMP biosynthetic process Source: MTBBASE
  • intracellular signal transduction Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein Rv1318c
Gene namesi
Ordered Locus Names:Rv1318c
ORF Names:MTCY130.03c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1318c

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytosol Source: MTBBASE
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957521 – 541Uncharacterized protein Rv1318cAdd BLAST541

Proteomic databases

PaxDbiP9WQ33

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1318c

Structurei

3D structure databases

ProteinModelPortaliP9WQ33
SMRiP9WQ33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini278 – 329HAMPPROSITE-ProRule annotationAdd BLAST52
Domaini361 – 485Guanylate cyclasePROSITE-ProRule annotationAdd BLAST125

Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105F8J Bacteria
COG2114 LUCA
KOiK01768
OMAiNTFLAPW
PhylomeDBiP9WQ33

Family and domain databases

CDDicd06225 HAMP, 1 hit
Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR003660 HAMP_dom
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF00672 HAMP, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SM00304 HAMP, 1 hit
SUPFAMiSSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50885 HAMP, 1 hit

Sequencei

Sequence statusi: Complete.

P9WQ33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKSTAQR LGRVLETVTR QSGRLPETPA YGSWLLGRVS ESQRRRRVRI
60 70 80 90 100
QVMLTALVVT ANLLGIGVAL LLVTIAIPEP SIVRDTPRWL TFGVVPGYVL
110 120 130 140 150
LALALGSYAL TRQTVQALRW AIEGRKPTRE EERRTFLAPW RVAVGHLMFW
160 170 180 190 200
GVGTALLTTL YGLINNAFIP RFLFAVSFCG VLVATATYLH TEFALRPFAA
210 220 230 240 250
QALEAGPPPR RLAPGILGRT MVVWLLGSGV PVVGIALMAM FEMVLLNLTR
260 270 280 290 300
MQFATGVLII SMVTLVFGFI LMWILAWLTA TPVRVVRAAL RRVERGELRT
310 320 330 340 350
NLVVFDGTEL GELQRGFNAM VAGLRERERV RDLFGRHVGR EVAAAAERER
360 370 380 390 400
SKLGGEERHV AVVFIDIVGS TQLVTSRPPA DVVKLLNKFF AIVVDEVDRH
410 420 430 440 450
HGLVNKFEGD ASLTIFGAPN RLPCPEDKAL AAARAIADRL VNEMPECQAG
460 470 480 490 500
IGVAAGQVIA GNVGARERFE YTVIGEPVNE AARLCELAKS RPGKLLASAQ
510 520 530 540
AVDAASEEER ARWSLGRHVK LRGHDQPVRL AKPVGLTKPR R
Length:541
Mass (Da):59,332
Last modified:April 16, 2014 - v1
Checksum:i24949CC8214386B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44075.1
PIRiB70769
RefSeqiNP_215834.1, NC_000962.3
WP_003406864.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP44075; CCP44075; Rv1318c
GeneIDi886910
KEGGimtu:Rv1318c

Similar proteinsi

Entry informationi

Entry nameiY1318_MYCTU
AccessioniPrimary (citable) accession number: P9WQ33
Secondary accession number(s): L0T7X3, P63527, Q10631
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: March 28, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health