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Protein

Cation-transporting P-type ATPase A

Gene

ctpA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi25 – 251PROSITE-ProRule annotation
Metal bindingi28 – 281PROSITE-ProRule annotation
Active sitei443 – 44314-aspartylphosphate intermediateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting P-type ATPase A (EC:3.6.3.-)
Gene namesi
Name:ctpA
Ordered Locus Names:Rv0092
ORF Names:MTCY251.11
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0092.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence analysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence analysisAdd
BLAST
Transmembranei548 – 56821HelicalSequence analysisAdd
BLAST
Transmembranei650 – 67021HelicalSequence analysisAdd
BLAST
Transmembranei703 – 72321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • extracellular region Source: MTBBASE
  • integral component of plasma membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 761760Cation-transporting P-type ATPase APRO_0000046165Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP9WPU1.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0092.

Structurei

3D structure databases

ProteinModelPortaliP9WPU1.
SMRiP9WPU1. Positions 14-79, 101-740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 7965HMAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK12949.
OMAiDLSVMFA.
PhylomeDBiP9WPU1.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P9WPU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAVTGEHH ASVQRIQLRI SGMSCSACAH RVESTLNKLP GVRAAVNFGT
60 70 80 90 100
RVATIDTSEA VDAAALCQAV RRAGYQADLC TDDGRSASDP DADHARQLLI
110 120 130 140 150
RLAIAAVLFV PVADLSVMFG VVPATRFTGW QWVLSALALP VVTWAAWPFH
160 170 180 190 200
RVAMRNARHH AASMETLISV GITAATIWSL YTVFGNHSPI ERSGIWQALL
210 220 230 240 250
GSDAIYFEVA AGVTVFVLVG RYFEARAKSQ AGSALRALAA LSAKEVAVLL
260 270 280 290 300
PDGSEMVIPA DELKEQQRFV VRPGQIVAAD GLAVDGSAAV DMSAMTGEAK
310 320 330 340 350
PTRVRPGGQV IGGTTVLDGR LIVEAAAVGA DTQFAGMVRL VEQAQAQKAD
360 370 380 390 400
AQRLADRISS VFVPAVLVIA ALTAAGWLIA GGQPDRAVSA ALAVLVIACP
410 420 430 440 450
CALGLATPTA MMVASGRGAQ LGIFLKGYKS LEATRAVDTV VFDKTGTLTT
460 470 480 490 500
GRLQVSAVTA APGWEADQVL ALAATVEAAS EHSVALAIAA ATTRRDAVTD
510 520 530 540 550
FRAIPGRGVS GTVSGRAVRV GKPSWIGSSS CHPNMRAARR HAESLGETAV
560 570 580 590 600
FVEVDGEPCG VIAVADAVKD SARDAVAALA DRGLRTMLLT GDNPESAAAV
610 620 630 640 650
ATRVGIDEVI ADILPEGKVD VIEQLRDRGH VVAMVGDGIN DGPALARADL
660 670 680 690 700
GMAIGRGTDV AIGAADIILV RDHLDVVPLA LDLARATMRT VKLNMVWAFG
710 720 730 740 750
YNIAAIPVAA AGLLNPLVAG AAMAFSSFFV VSNSLRLRKF GRYPLGCGTV
760
GGPQMTAPSS A
Length:761
Mass (Da):78,851
Last modified:April 16, 2014 - v1
Checksum:iD397901EC5C513BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42817.1.
PIRiD70750.
RefSeqiNP_214606.1. NC_000962.3.
WP_003899808.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP42817; CCP42817; Rv0092.
GeneIDi886946.
KEGGimtu:Rv0092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42817.1.
PIRiD70750.
RefSeqiNP_214606.1. NC_000962.3.
WP_003899808.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP9WPU1.
SMRiP9WPU1. Positions 14-79, 101-740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0092.

Proteomic databases

PaxDbiP9WPU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP42817; CCP42817; Rv0092.
GeneIDi886946.
KEGGimtu:Rv0092.

Organism-specific databases

TubercuListiRv0092.

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK12949.
OMAiDLSVMFA.
PhylomeDBiP9WPU1.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiCTPA_MYCTU
AccessioniPrimary (citable) accession number: P9WPU1
Secondary accession number(s): L0T5H9, Q10876
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 6, 2016
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.