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Protein

Cation-transporting P-type ATPase B

Gene

ctpB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261PROSITE-ProRule annotation
Metal bindingi29 – 291PROSITE-ProRule annotation
Active sitei446 – 44614-aspartylphosphate intermediateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting P-type ATPase B (EC:3.6.3.-)
Gene namesi
Name:ctpB
Ordered Locus Names:Rv0103c
ORF Names:MTCY251.22c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0103c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence analysisAdd
BLAST
Transmembranei390 – 41021HelicalSequence analysisAdd
BLAST
Transmembranei491 – 51121HelicalSequence analysisAdd
BLAST
Transmembranei714 – 73421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: MTBBASE
  • integral component of plasma membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: GO_Central
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 752752Cation-transporting P-type ATPase BPRO_0000046168Add
BLAST

Proteomic databases

PaxDbiP9WPT9.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0103c.

Structurei

3D structure databases

ProteinModelPortaliP9WPT9.
SMRiP9WPT9. Positions 17-749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 7964HMAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK12949.
OMAiIHHDEVE.
PhylomeDBiP9WPT9.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P9WPT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVVGDAD LQSVRRIRLD VLGMSCAACA SRVETKLNKI PGVRASVNFA
60 70 80 90 100
TRVATIDAVG MAADELCGVV EKAGYHAAPH TETTVLDKRT KDPDGAHARR
110 120 130 140 150
LLRRLLVAAV LFVPLADLST LFAIVPSARV PGWGYILTAL AAPVVTWAAW
160 170 180 190 200
PFHSVALRNA RHRTTSMETL ISVGIVAATA WSLSSVFGDQ PPREGSGIWR
210 220 230 240 250
AILNSDSIYL EVAAGVTVFV LAGRYFEARA KSKAGSALRA LAELGAKNVA
260 270 280 290 300
VLLPDGAELV IPASELKKRQ RFVTRPGETI AADGVVVDGS AAIDMSAMTG
310 320 330 340 350
EAKPVRAYPA ASVVGGTVVM DGRLVIEATA VGADTQFAAM VRLVEQAQTQ
360 370 380 390 400
KARAQRLADH IAGVFVPVVF VIAGLAGAAW LVSGAGADRA FSVTLGVLVI
410 420 430 440 450
ACPCALGLAT PTAMMVASGR GAQLGIFIKG YRALETIRSI DTVVFDKTGT
460 470 480 490 500
LTVGQLAVST VTMAGSGTSE RDREEVLGLA AAVESASEHA MAAAIVAASP
510 520 530 540 550
DPGPVNGFVA VAGCGVSGEV GGHHVEVGKP SWITRTTPCH DAALVSARLD
560 570 580 590 600
GESRGETVVF VSVDGVVRAA LTIADTLKDS AAAAVAALRS RGLRTILLTG
610 620 630 640 650
DNRAAADAVA AQVGIDSAVA DMLPEGKVDV IQRLREEGHT VAMVGDGIND
660 670 680 690 700
GPALVGADLG LAIGRGTDVA LGAADIILVR DDLNTVPQAL DLARATMRTI
710 720 730 740 750
RMNMIWAFGY NVAAIPIAAA GLLNPLIAGA AMAFSSFFVV SNSLRLRNFG

AQ
Length:752
Mass (Da):77,509
Last modified:April 16, 2014 - v1
Checksum:i21563FE4B4407505
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07638 Genomic DNA. Translation: CAA68915.1.
AL123456 Genomic DNA. Translation: CCP42828.1.
PIRiG70751.
RefSeqiNP_214617.1. NC_000962.3.
WP_009935939.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP42828; CCP42828; Rv0103c.
GeneIDi886928.
KEGGimtu:Rv0103c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07638 Genomic DNA. Translation: CAA68915.1.
AL123456 Genomic DNA. Translation: CCP42828.1.
PIRiG70751.
RefSeqiNP_214617.1. NC_000962.3.
WP_009935939.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP9WPT9.
SMRiP9WPT9. Positions 17-749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0103c.

Proteomic databases

PaxDbiP9WPT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP42828; CCP42828; Rv0103c.
GeneIDi886928.
KEGGimtu:Rv0103c.

Organism-specific databases

TubercuListiRv0103c.

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK12949.
OMAiIHHDEVE.
PhylomeDBiP9WPT9.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Agranoff D.D., Krishna S.K., Griffin G.E., Mangan J.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiCTPB_MYCTU
AccessioniPrimary (citable) accession number: P9WPT9
Secondary accession number(s): L0T4B7, P77905, Q10877
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 6, 2016
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.