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Protein

Cation-transporting P-type ATPase B

Gene

ctpB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26PROSITE-ProRule annotation1
Metal bindingi29PROSITE-ProRule annotation1
Active sitei4464-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting P-type ATPase B (EC:3.6.3.-)
Gene namesi
Name:ctpB
Ordered Locus Names:Rv0103c
ORF Names:MTCY251.22c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0103c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Transmembranei714 – 734HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytosol Source: MTBBASE
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MTBBASE

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461681 – 752Cation-transporting P-type ATPase BAdd BLAST752

Proteomic databases

PaxDbiP9WPT9.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0103c.

Structurei

3D structure databases

ProteinModelPortaliP9WPT9.
SMRiP9WPT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 79HMAPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK12949.
OMAiQAMKVKV.
PhylomeDBiP9WPT9.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_dom_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom_sf.
IPR008250. ATPase_P-typ_transduc_dom_A_sf.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR036412. HAD-like_sf.
IPR023214. HAD_sf.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR036163. HMA_dom_sf.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00403. HMA. 1 hit.
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WPT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVVGDAD LQSVRRIRLD VLGMSCAACA SRVETKLNKI PGVRASVNFA
60 70 80 90 100
TRVATIDAVG MAADELCGVV EKAGYHAAPH TETTVLDKRT KDPDGAHARR
110 120 130 140 150
LLRRLLVAAV LFVPLADLST LFAIVPSARV PGWGYILTAL AAPVVTWAAW
160 170 180 190 200
PFHSVALRNA RHRTTSMETL ISVGIVAATA WSLSSVFGDQ PPREGSGIWR
210 220 230 240 250
AILNSDSIYL EVAAGVTVFV LAGRYFEARA KSKAGSALRA LAELGAKNVA
260 270 280 290 300
VLLPDGAELV IPASELKKRQ RFVTRPGETI AADGVVVDGS AAIDMSAMTG
310 320 330 340 350
EAKPVRAYPA ASVVGGTVVM DGRLVIEATA VGADTQFAAM VRLVEQAQTQ
360 370 380 390 400
KARAQRLADH IAGVFVPVVF VIAGLAGAAW LVSGAGADRA FSVTLGVLVI
410 420 430 440 450
ACPCALGLAT PTAMMVASGR GAQLGIFIKG YRALETIRSI DTVVFDKTGT
460 470 480 490 500
LTVGQLAVST VTMAGSGTSE RDREEVLGLA AAVESASEHA MAAAIVAASP
510 520 530 540 550
DPGPVNGFVA VAGCGVSGEV GGHHVEVGKP SWITRTTPCH DAALVSARLD
560 570 580 590 600
GESRGETVVF VSVDGVVRAA LTIADTLKDS AAAAVAALRS RGLRTILLTG
610 620 630 640 650
DNRAAADAVA AQVGIDSAVA DMLPEGKVDV IQRLREEGHT VAMVGDGIND
660 670 680 690 700
GPALVGADLG LAIGRGTDVA LGAADIILVR DDLNTVPQAL DLARATMRTI
710 720 730 740 750
RMNMIWAFGY NVAAIPIAAA GLLNPLIAGA AMAFSSFFVV SNSLRLRNFG

AQ
Length:752
Mass (Da):77,509
Last modified:April 16, 2014 - v1
Checksum:i21563FE4B4407505
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07638 Genomic DNA. Translation: CAA68915.1.
AL123456 Genomic DNA. Translation: CCP42828.1.
PIRiG70751.
RefSeqiNP_214617.1. NC_000962.3.
WP_009935939.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP42828; CCP42828; Rv0103c.
GeneIDi886928.
KEGGimtu:Rv0103c.

Similar proteinsi

Entry informationi

Entry nameiCTPB_MYCTU
AccessioniPrimary (citable) accession number: P9WPT9
Secondary accession number(s): L0T4B7, P77905, Q10877
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 22, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families