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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB), Glycerol-3-phosphate acyltransferase (LH57_08485), Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (LH57_15725), Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • CDP-diacylglycerol biosynthetic process Source: GO_Central
  • growth Source: MTBBASE
  • phosphatidylglycerol biosynthetic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7133-MONOMER.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:Rv2881c
ORF Names:MTCY274.12c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2881c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: GO_Central
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907431 – 328Phosphatidate cytidylyltransferaseAdd BLAST328
Isoform 2 (identifier: P9WPF7-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: P9WPF7-2)
Modified residuei2N-acetylthreonineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP9WPF7.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2881c.

Structurei

3D structure databases

ProteinModelPortaliP9WPF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105KNE. Bacteria.
COG0575. LUCA.
KOiK00981.
OMAiQTRPMPI.
PhylomeDBiP9WPF7.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: P9WPF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWLNTKKAS CWRSSGRSAT KSVTTNDAGT GNPAEQPARG AKQQPATETS
60 70 80 90 100
RAGRDLRAAI VVGLSIGLVL IAVLVFVPRV WVAIVAVATL VATHEVVRRL
110 120 130 140 150
REAGYLIPVI PLLIGGQAAV WLTWPFGAVG ALAGFGGMVV VCMIWRLFMQ
160 170 180 190 200
DSVTRPTTGG APSPGNYLSD VSATVFLAVW VPLFCSFGAM LVYPENGSGW
210 220 230 240 250
VFCMMIAVIA SDVGGYAVGV LFGKHPMVPT ISPKKSWEGF AGSLVCGITA
260 270 280 290 300
TIITATFLVG KTPWIGALLG VLFVLTTALG DLVESQVKRD LGIKDMGRLL
310 320
PGHGGLMDRL DGILPSAVAA WIVLTLLP
Length:328
Mass (Da):34,458
Last modified:November 2, 2016 - v2
Checksum:i3C80533E32CD2ED1
GO
Isoform 2 (identifier: P9WPF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Show »
Length:306
Mass (Da):32,003
Checksum:i80F31E40846A529F
GO

Sequence cautioni

The sequence CCP45683 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0585981 – 22Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45683.1. Different initiation.
PIRiD70924.
RefSeqiNP_217397.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP45683; CCP45683; Rv2881c.
GeneIDi888910.
KEGGimtu:Rv2881c.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45683.1. Different initiation.
PIRiD70924.
RefSeqiNP_217397.1. NC_000962.3.

3D structure databases

ProteinModelPortaliP9WPF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2881c.

Proteomic databases

PaxDbiP9WPF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP45683; CCP45683; Rv2881c.
GeneIDi888910.
KEGGimtu:Rv2881c.

Organism-specific databases

TubercuListiRv2881c.

Phylogenomic databases

eggNOGiENOG4105KNE. Bacteria.
COG0575. LUCA.
KOiK00981.
OMAiQTRPMPI.
PhylomeDBiP9WPF7.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.
BioCyciMTBH37RV:G185E-7133-MONOMER.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDSA_MYCTU
AccessioniPrimary (citable) accession number: P9WPF7
Secondary accession number(s): L0TDN0, P63758, Q10807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: November 2, 2016
Last modified: November 30, 2016
This is version 20 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.