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Protein

Pantothenate kinase

Gene

coaA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (LH57_06005), Pantothenate kinase (LH57_19625), Pantothenate kinase (coaA), Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  4. Phosphopantetheine adenylyltransferase (LH57_16170), Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1048ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-HAMAP
  • pantothenate kinase activity Source: MTBBASE

GO - Biological processi

  • coenzyme A biosynthetic process Source: MTBBASE
  • growth Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase (EC:2.7.1.33)
Alternative name(s):
Pantothenic acid kinase
Gene namesi
Name:coaA
Ordered Locus Names:Rv1092c
ORF Names:MTV017.45c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1092c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Pantothenate kinasePRO_0000194439Add
BLAST

Proteomic databases

PaxDbiP9WPA7.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1092c.

Structurei

Secondary structure

1
312
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 146Combined sources
Helixi15 – 206Combined sources
Beta strandi23 – 253Combined sources
Helixi31 – 388Combined sources
Beta strandi42 – 443Combined sources
Helixi46 – 516Combined sources
Helixi53 – 7725Combined sources
Beta strandi82 – 843Combined sources
Beta strandi85 – 873Combined sources
Beta strandi91 – 977Combined sources
Helixi103 – 11412Combined sources
Beta strandi117 – 1193Combined sources
Beta strandi123 – 1275Combined sources
Helixi128 – 1314Combined sources
Helixi135 – 1406Combined sources
Helixi144 – 1463Combined sources
Helixi150 – 1523Combined sources
Helixi155 – 16612Combined sources
Beta strandi172 – 1787Combined sources
Turni179 – 1824Combined sources
Beta strandi183 – 19210Combined sources
Beta strandi196 – 2027Combined sources
Turni203 – 2064Combined sources
Beta strandi210 – 2123Combined sources
Helixi214 – 2174Combined sources
Beta strandi219 – 2268Combined sources
Helixi228 – 24215Combined sources
Turni243 – 2453Combined sources
Helixi246 – 2483Combined sources
Beta strandi249 – 2524Combined sources
Helixi255 – 2573Combined sources
Helixi262 – 27514Combined sources
Helixi277 – 2837Combined sources
Helixi286 – 2916Combined sources
Beta strandi293 – 2986Combined sources
Beta strandi304 – 3107Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GESX-ray2.40A1-312[»]
2GETX-ray2.35A1-312[»]
2GEUX-ray2.90A1-312[»]
2GEVX-ray2.35A1-312[»]
2ZS7X-ray2.65A1-312[»]
2ZS8X-ray2.80A1-312[»]
2ZS9X-ray2.70A1-312[»]
2ZSAX-ray2.50A1-312[»]
2ZSBX-ray2.75A1-312[»]
2ZSDX-ray2.50A1-312[»]
2ZSEX-ray2.50A1-312[»]
2ZSFX-ray2.80A1-312[»]
3AEZX-ray2.20A1-312[»]
3AF0X-ray2.50A1-312[»]
3AF1X-ray2.50A1-312[»]
3AF2X-ray2.30A1-312[»]
3AF3X-ray2.35A1-312[»]
3AF4X-ray2.60A1-312[»]
3AVOX-ray2.55A1-312[»]
3AVPX-ray2.60A1-312[»]
3AVQX-ray3.00A1-312[»]
4BFSX-ray2.90A1-312[»]
4BFTX-ray2.29A/B1-312[»]
4BFUX-ray2.28A/B1-312[»]
4BFVX-ray2.29A/B1-312[»]
4BFWX-ray2.27A/B1-312[»]
4BFXX-ray2.70A/B1-312[»]
4BFYX-ray2.30A/B1-312[»]
4BFZX-ray2.10A/B1-312[»]
ProteinModelPortaliP9WPA7.
SMRiP9WPA7. Positions 7-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CS9. Bacteria.
COG1072. LUCA.
KOiK00867.
OMAiLMQRKGF.
PhylomeDBiP9WPA7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WPA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLSEPSPY VEFDRRQWRA LRMSTPLALT EEELVGLRGL GEQIDLLEVE
60 70 80 90 100
EVYLPLARLI HLQVAARQRL FAATAEFLGE PQQNPDRPVP FIIGVAGSVA
110 120 130 140 150
VGKSTTARVL QALLARWDHH PRVDLVTTDG FLYPNAELQR RNLMHRKGFP
160 170 180 190 200
ESYNRRALMR FVTSVKSGSD YACAPVYSHL HYDIIPGAEQ VVRHPDILIL
210 220 230 240 250
EGLNVLQTGP TLMVSDLFDF SLYVDARIED IEQWYVSRFL AMRTTAFADP
260 270 280 290 300
ESHFHHYAAF SDSQAVVAAR EIWRTINRPN LVENILPTRP RATLVLRKDA
310
DHSINRLRLR KL
Length:312
Mass (Da):35,657
Last modified:April 16, 2014 - v1
Checksum:iF075B543AE75788D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43845.1.
PIRiB70896.
RefSeqiNP_215608.1. NC_000962.3.
WP_003405790.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP43845; CCP43845; Rv1092c.
GeneIDi885120.
KEGGimtu:Rv1092c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43845.1.
PIRiB70896.
RefSeqiNP_215608.1. NC_000962.3.
WP_003405790.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GESX-ray2.40A1-312[»]
2GETX-ray2.35A1-312[»]
2GEUX-ray2.90A1-312[»]
2GEVX-ray2.35A1-312[»]
2ZS7X-ray2.65A1-312[»]
2ZS8X-ray2.80A1-312[»]
2ZS9X-ray2.70A1-312[»]
2ZSAX-ray2.50A1-312[»]
2ZSBX-ray2.75A1-312[»]
2ZSDX-ray2.50A1-312[»]
2ZSEX-ray2.50A1-312[»]
2ZSFX-ray2.80A1-312[»]
3AEZX-ray2.20A1-312[»]
3AF0X-ray2.50A1-312[»]
3AF1X-ray2.50A1-312[»]
3AF2X-ray2.30A1-312[»]
3AF3X-ray2.35A1-312[»]
3AF4X-ray2.60A1-312[»]
3AVOX-ray2.55A1-312[»]
3AVPX-ray2.60A1-312[»]
3AVQX-ray3.00A1-312[»]
4BFSX-ray2.90A1-312[»]
4BFTX-ray2.29A/B1-312[»]
4BFUX-ray2.28A/B1-312[»]
4BFVX-ray2.29A/B1-312[»]
4BFWX-ray2.27A/B1-312[»]
4BFXX-ray2.70A/B1-312[»]
4BFYX-ray2.30A/B1-312[»]
4BFZX-ray2.10A/B1-312[»]
ProteinModelPortaliP9WPA7.
SMRiP9WPA7. Positions 7-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1092c.

Proteomic databases

PaxDbiP9WPA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43845; CCP43845; Rv1092c.
GeneIDi885120.
KEGGimtu:Rv1092c.

Organism-specific databases

TubercuListiRv1092c.

Phylogenomic databases

eggNOGiENOG4105CS9. Bacteria.
COG1072. LUCA.
KOiK00867.
OMAiLMQRKGF.
PhylomeDBiP9WPA7.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. "targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis."
    Raman K., Yeturu K., Chandra N.
    BMC Syst. Biol. 2:109-109(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiCOAA_MYCTU
AccessioniPrimary (citable) accession number: P9WPA7
Secondary accession number(s): L0T5P3, O53440, P63810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 11, 2015
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Was identified as a high-confidence drug target.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.