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Protein

Cytochrome bc1 complex cytochrome c subunit

Gene

qcrC

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of ubiquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.Curated

Miscellaneous

Was identified as a high-confidence drug target.1 Publication

Catalytic activityi

Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73Heme 1 (covalent)PROSITE-ProRule annotation1
Binding sitei76Heme 1 (covalent)PROSITE-ProRule annotation1
Metal bindingi77Iron (heme 1 axial ligand)PROSITE-ProRule annotation1
Binding sitei174Heme 2 (covalent)PROSITE-ProRule annotation1
Binding sitei177Heme 2 (covalent)PROSITE-ProRule annotation1
Metal bindingi178Iron (heme 2 axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • growth Source: MTBBASE

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome bc1 complex cytochrome c subunit (EC:1.10.2.2Curated)
Alternative name(s):
Cytochrome bc1 reductase complex subunit QcrC
Ubiquinol--cytochrome c reductase cytochrome c subunit
Gene namesi
Name:qcrC
Ordered Locus Names:Rv2194
ORF Names:MTCY190.05
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2194.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: MTBBASE
  • respiratory chain Source: UniProtKB-KW

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001084501 – 280Cytochrome bc1 complex cytochrome c subunitAdd BLAST280

Post-translational modificationi

Binds 2 heme groups covalently per subunit.By similarity

Proteomic databases

PaxDbiP9WP35.

Interactioni

Subunit structurei

The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.Curated

Protein-protein interaction databases

STRINGi83332.Rv2194.

Structurei

3D structure databases

ProteinModelPortaliP9WP35.
SMRiP9WP35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 140Cytochrome c 1PROSITE-ProRule annotationAdd BLAST81
Domaini161 – 239Cytochrome c 2PROSITE-ProRule annotationAdd BLAST79

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107UDY. Bacteria.
COG2010. LUCA.
KOiK03889.
OMAiLFRTNCA.
PhylomeDBiP9WP35.

Family and domain databases

Gene3Di1.10.760.10. 2 hits.
InterProiView protein in InterPro
IPR009152. bc1_cytC-su.
IPR009056. Cyt_c-like_dom.
PfamiView protein in Pfam
PF00034. Cytochrom_C. 1 hit.
PF13442. Cytochrome_CBB3. 1 hit.
PIRSFiPIRSF000007. Ubiq_cycred_cyc. 1 hit.
SUPFAMiSSF46626. SSF46626. 2 hits.
PROSITEiView protein in PROSITE
PS51007. CYTC. 2 hits.

Sequencei

Sequence statusi: Complete.

P9WP35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLGFTRSG GSKSGRTRRR LRRRLSGGVL LLIALTIAGG LAAVLTPTPQ
60 70 80 90 100
VAVADESSSA LLRTGKQLFD TSCVSCHGAN LQGVPDHGPS LIGVGEAAVY
110 120 130 140 150
FQVSTGRMPA MRGEAQAPRK DPIFDEAQID AIGAYVQANG GGPTVVRNPD
160 170 180 190 200
GSIATQSLRG NDLGRGGDLF RLNCASCHNF TGKGGALSSG KYAPDLAPAN
210 220 230 240 250
EQQILTAMLT GPQNMPKFSN RQLSFEAKKD IIAYVKVATE ARQPGGYLLG
260 270 280
GFGPAPEGMA MWIIGMVAAI GLALWIGARS
Length:280
Mass (Da):29,138
Last modified:April 16, 2014 - v1
Checksum:i7A058AE7E12EF713
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44971.1.
PIRiC70784.
RefSeqiNP_216710.1. NC_000962.3.
WP_003411392.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44971; CCP44971; Rv2194.
GeneIDi888737.
KEGGimtu:Rv2194.
mtv:RVBD_2194.
PATRICifig|83332.111.peg.2441.

Similar proteinsi

Entry informationi

Entry nameiQCRC_MYCTU
AccessioniPrimary (citable) accession number: P9WP35
Secondary accession number(s): L0TBS3, P63887, Q10386
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 5, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names