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Protein

Probable enoyl-CoA hydratase echA8

Gene

echA8

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Could possibly oxidize fatty acids using specific components.By similarity

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable enoyl-CoA hydratase echA8 (EC:4.2.1.17)
Gene namesi
Name:echA8
Ordered Locus Names:Rv1070c
ORF Names:MTV017.23c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1070c.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Probable enoyl-CoA hydratase echA8PRO_0000109338Add
BLAST

Proteomic databases

PaxDbiP9WNN9.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1070c.

Structurei

Secondary structure

1
257
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 118Combined sources
Beta strandi14 – 196Combined sources
Helixi22 – 243Combined sources
Helixi30 – 4415Combined sources
Beta strandi51 – 555Combined sources
Beta strandi58 – 625Combined sources
Helixi68 – 714Combined sources
Helixi75 – 817Combined sources
Turni82 – 843Combined sources
Helixi85 – 873Combined sources
Helixi88 – 914Combined sources
Beta strandi97 – 1015Combined sources
Beta strandi103 – 1064Combined sources
Helixi108 – 1158Combined sources
Beta strandi116 – 1227Combined sources
Beta strandi126 – 1283Combined sources
Helixi130 – 1345Combined sources
Helixi142 – 1509Combined sources
Helixi152 – 16110Combined sources
Beta strandi164 – 1663Combined sources
Helixi167 – 1726Combined sources
Beta strandi177 – 1804Combined sources
Helixi182 – 1843Combined sources
Helixi185 – 19713Combined sources
Helixi201 – 21313Combined sources
Turni214 – 2163Combined sources
Helixi219 – 23315Combined sources
Helixi237 – 24711Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H81X-ray1.80A/B/C1-257[»]
3PZKX-ray2.23A/B/C1-257[»]
3Q0GX-ray2.38A/B/C/D/E/F1-257[»]
3Q0JX-ray2.40A/B/C/D/E/F1-257[»]
4FJWX-ray2.20D/E/F1-257[»]
ProteinModelPortaliP9WNN9.
SMRiP9WNN9. Positions 2-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E39. Bacteria.
COG1024. LUCA.
KOiK01692.
OMAiVSKIYPV.
PhylomeDBiP9WNN9.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P9WNN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYETILVER DQRVGIITLN RPQALNALNS QVMNEVTSAA TELDDDPDIG
60 70 80 90 100
AIIITGSAKA FAAGADIKEM ADLTFADAFT ADFFATWGKL AAVRTPTIAA
110 120 130 140 150
VAGYALGGGC ELAMMCDVLI AADTAKFGQP EIKLGVLPGM GGSQRLTRAI
160 170 180 190 200
GKAKAMDLIL TGRTMDAAEA ERSGLVSRVV PADDLLTEAR ATATTISQMS
210 220 230 240 250
ASAARMAKEA VNRAFESSLS EGLLYERRLF HSAFATEDQS EGMAAFIEKR

APQFTHR
Length:257
Mass (Da):27,273
Last modified:April 16, 2014 - v1
Checksum:iC8907716969540AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43821.1.
PIRiD70893.
RefSeqiNP_215586.1. NC_000962.3.
WP_003405712.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP43821; CCP43821; Rv1070c.
GeneIDi887117.
KEGGimtu:Rv1070c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43821.1.
PIRiD70893.
RefSeqiNP_215586.1. NC_000962.3.
WP_003405712.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H81X-ray1.80A/B/C1-257[»]
3PZKX-ray2.23A/B/C1-257[»]
3Q0GX-ray2.38A/B/C/D/E/F1-257[»]
3Q0JX-ray2.40A/B/C/D/E/F1-257[»]
4FJWX-ray2.20D/E/F1-257[»]
ProteinModelPortaliP9WNN9.
SMRiP9WNN9. Positions 2-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1070c.

Proteomic databases

PaxDbiP9WNN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43821; CCP43821; Rv1070c.
GeneIDi887117.
KEGGimtu:Rv1070c.

Organism-specific databases

TubercuListiRv1070c.

Phylogenomic databases

eggNOGiENOG4105E39. Bacteria.
COG1024. LUCA.
KOiK01692.
OMAiVSKIYPV.
PhylomeDBiP9WNN9.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECHA8_MYCTU
AccessioniPrimary (citable) accession number: P9WNN9
Secondary accession number(s): L0T5R3, O53418, P64016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 7, 2016
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.