Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable enoyl-CoA hydratase echA8

Gene

echA8

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Could possibly oxidize fatty acids using specific components.By similarity

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5232-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable enoyl-CoA hydratase echA8 (EC:4.2.1.17)
Gene namesi
Name:echA8
Ordered Locus Names:Rv1070c
ORF Names:MTV017.23c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1070c.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001093381 – 257Probable enoyl-CoA hydratase echA8Add BLAST257

Proteomic databases

PaxDbiP9WNN9.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1070c.

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Beta strandi14 – 19Combined sources6
Helixi22 – 24Combined sources3
Helixi30 – 44Combined sources15
Beta strandi51 – 55Combined sources5
Beta strandi58 – 62Combined sources5
Helixi68 – 71Combined sources4
Helixi75 – 81Combined sources7
Turni82 – 84Combined sources3
Helixi85 – 87Combined sources3
Helixi88 – 91Combined sources4
Beta strandi97 – 101Combined sources5
Beta strandi103 – 106Combined sources4
Helixi108 – 115Combined sources8
Beta strandi116 – 122Combined sources7
Beta strandi126 – 128Combined sources3
Helixi130 – 134Combined sources5
Helixi142 – 150Combined sources9
Helixi152 – 161Combined sources10
Beta strandi164 – 166Combined sources3
Helixi167 – 172Combined sources6
Beta strandi177 – 180Combined sources4
Helixi182 – 184Combined sources3
Helixi185 – 197Combined sources13
Helixi201 – 213Combined sources13
Turni214 – 216Combined sources3
Helixi219 – 233Combined sources15
Helixi237 – 247Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H81X-ray1.80A/B/C1-257[»]
3PZKX-ray2.23A/B/C1-257[»]
3Q0GX-ray2.38A/B/C/D/E/F1-257[»]
3Q0JX-ray2.40A/B/C/D/E/F1-257[»]
4FJWX-ray2.20D/E/F1-257[»]
ProteinModelPortaliP9WNN9.
SMRiP9WNN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E39. Bacteria.
COG1024. LUCA.
KOiK01692.
OMAiVSKIYPV.
PhylomeDBiP9WNN9.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P9WNN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYETILVER DQRVGIITLN RPQALNALNS QVMNEVTSAA TELDDDPDIG
60 70 80 90 100
AIIITGSAKA FAAGADIKEM ADLTFADAFT ADFFATWGKL AAVRTPTIAA
110 120 130 140 150
VAGYALGGGC ELAMMCDVLI AADTAKFGQP EIKLGVLPGM GGSQRLTRAI
160 170 180 190 200
GKAKAMDLIL TGRTMDAAEA ERSGLVSRVV PADDLLTEAR ATATTISQMS
210 220 230 240 250
ASAARMAKEA VNRAFESSLS EGLLYERRLF HSAFATEDQS EGMAAFIEKR

APQFTHR
Length:257
Mass (Da):27,273
Last modified:April 16, 2014 - v1
Checksum:iC8907716969540AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43821.1.
PIRiD70893.
RefSeqiNP_215586.1. NC_000962.3.
WP_003405712.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP43821; CCP43821; Rv1070c.
GeneIDi887117.
KEGGimtu:Rv1070c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43821.1.
PIRiD70893.
RefSeqiNP_215586.1. NC_000962.3.
WP_003405712.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H81X-ray1.80A/B/C1-257[»]
3PZKX-ray2.23A/B/C1-257[»]
3Q0GX-ray2.38A/B/C/D/E/F1-257[»]
3Q0JX-ray2.40A/B/C/D/E/F1-257[»]
4FJWX-ray2.20D/E/F1-257[»]
ProteinModelPortaliP9WNN9.
SMRiP9WNN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1070c.

Proteomic databases

PaxDbiP9WNN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43821; CCP43821; Rv1070c.
GeneIDi887117.
KEGGimtu:Rv1070c.

Organism-specific databases

TubercuListiRv1070c.

Phylogenomic databases

eggNOGiENOG4105E39. Bacteria.
COG1024. LUCA.
KOiK01692.
OMAiVSKIYPV.
PhylomeDBiP9WNN9.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5232-MONOMER.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECHA8_MYCTU
AccessioniPrimary (citable) accession number: P9WNN9
Secondary accession number(s): L0T5R3, O53418, P64016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 2, 2016
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.