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Protein

Glycine cleavage system H protein

Gene

gcvH

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H proteinUniRule annotation
Gene namesi
Name:gcvHUniRule annotation
Ordered Locus Names:Rv1826
ORF Names:MTCY1A11.17c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1826.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001662282 – 134Glycine cleavage system H proteinAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei65N6-lipoyllysineUniRule annotation1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP9WN55.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi83332.Rv1826.

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 21Combined sources8
Beta strandi24 – 29Combined sources6
Helixi31 – 37Combined sources7
Beta strandi39 – 44Combined sources6
Beta strandi57 – 65Combined sources9
Beta strandi67 – 71Combined sources5
Beta strandi73 – 81Combined sources9
Helixi84 – 87Combined sources4
Helixi91 – 94Combined sources4
Turni96 – 100Combined sources5
Beta strandi103 – 106Combined sources4
Turni109 – 111Combined sources3
Helixi115 – 119Combined sources5
Helixi125 – 131Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HGBX-ray1.75A1-134[»]
3IFTX-ray2.00A2-134[»]
5EXKX-ray1.86B/D/F/H/J/L62-69[»]
ProteinModelPortaliP9WN55.
SMRiP9WN55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 106Lipoyl-bindingPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the GcvH family.UniRule annotation

Keywords - Domaini

Lipoyl

Phylogenomic databases

eggNOGiENOG4105KE9. Bacteria.
COG0509. LUCA.
KOiK02437.
OMAiIVYVEVE.
PhylomeDBiP9WN55.

Family and domain databases

CDDicd06848. GCS_H. 1 hit.
HAMAPiMF_00272. GcvH. 1 hit.
InterProiView protein in InterPro
IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR000089. Biotin_lipoyl.
IPR002930. GCV_H.
IPR033753. GCV_H/Fam206.
IPR017453. GCV_H_sub.
IPR011053. Single_hybrid_motif.
PANTHERiPTHR11715. PTHR11715. 1 hit.
PfamiView protein in Pfam
PF01597. GCV_H. 1 hit.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00527. gcvH. 1 hit.
PROSITEiView protein in PROSITE
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P9WN55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIPSDLHY TAEHEWIRRS GDDTVRVGIT DYAQSALGDV VFVQLPVIGT
60 70 80 90 100
AVTAGETFGE VESTKSVSDL YAPISGKVSE VNSDLDGTPQ LVNSDPYGAG
110 120 130
WLLDIQVDSS DVAALESALT TLLDAEAYRG TLTE
Length:134
Mass (Da):14,238
Last modified:April 16, 2014 - v1
Checksum:i06D2A553236E7668
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44592.1.
PIRiC70721.
RefSeqiNP_216342.1. NC_000962.3.
WP_003899040.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44592; CCP44592; Rv1826.
GeneIDi885720.
KEGGimtu:Rv1826.

Similar proteinsi

Entry informationi

Entry nameiGCSH_MYCTU
AccessioniPrimary (citable) accession number: P9WN55
Secondary accession number(s): L0T7T4, Q50607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: August 30, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families