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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Miscellaneous

Was identified as a high-confidence drug target.

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cell wall organization Source: UniProtKB-KW
  • growth Source: MTBBASE
  • peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  • regulation of cell shape Source: UniProtKB-KW

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Synonyms:murX
Ordered Locus Names:Rv2156c
ORF Names:MTCY270.12
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2156c.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei55 – 75HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei156 – 176HelicalUniRule annotationAdd BLAST21
Transmembranei187 – 207HelicalUniRule annotationAdd BLAST21
Transmembranei231 – 251HelicalUniRule annotationAdd BLAST21
Transmembranei255 – 275HelicalUniRule annotationAdd BLAST21
Transmembranei280 – 300HelicalUniRule annotationAdd BLAST21
Transmembranei334 – 354HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1921665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088561 – 359Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST359

Proteomic databases

PaxDbiP9WMW7.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2156c.

Structurei

3D structure databases

ProteinModelPortaliP9WMW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
KOiK01000.
OMAiLMSPLHH.
PhylomeDBiP9WMW7.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WMW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQILIAVAV AVTVSILLTP VLIRLFTKQG FGHQIREDGP PSHHTKRGTP
60 70 80 90 100
SMGGVAILAG IWAGYLGAHL AGLAFDGEGI GASGLLVLGL ATALGGVGFI
110 120 130 140 150
DDLIKIRRSR NLGLNKTAKT VGQITSAVLF GVLVLQFRNA AGLTPGSADL
160 170 180 190 200
SYVREIATVT LAPVLFVLFC VVIVSAWSNA VNFTDGLDGL AAGTMAMVTA
210 220 230 240 250
AYVLITFWQY RNACVTAPGL GCYNVRDPLD LALIAAATAG ACIGFLWWNA
260 270 280 290 300
APAKIFMGDT GSLALGGVIA GLSVTSRTEI LAVVLGALFV AEITSVVLQI
310 320 330 340 350
LTFRTTGRRM FRMAPFHHHF ELVGWAETTV IIRFWLLTAI TCGLGVALFY

GEWLAAVGA
Length:359
Mass (Da):37,713
Last modified:April 16, 2014 - v1
Checksum:i27E979BC77BA28C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44932.1.
PIRiH70579.
RefSeqiNP_216672.1. NC_000962.3.
WP_003411171.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44932; CCP44932; Rv2156c.
GeneIDi888098.
KEGGimtu:Rv2156c.

Similar proteinsi

Entry informationi

Entry nameiMRAY_MYCTU
AccessioniPrimary (citable) accession number: P9WMW7
Secondary accession number(s): L0TBH3, O06221, P64259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 7, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families