Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P9WMP1

- PPOX_MYCTU

UniProt

P9WMP1 - PPOX_MYCTU

Protein

Protoporphyrinogen oxidase

Gene

hemY

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 6 (01 Oct 2014)
      Sequence version 1 (16 Apr 2014)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.By similarity

    Catalytic activityi

    Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei242 – 2421FAD; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei390 – 3901FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156FADBy similarity
    Nucleotide bindingi36 – 372FADBy similarity
    Nucleotide bindingi58 – 614FADBy similarity
    Nucleotide bindingi426 – 4283FADBy similarity

    GO - Molecular functioni

    1. oxygen-dependent protoporphyrinogen oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00324.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protoporphyrinogen oxidase (EC:1.3.3.4)
    Short name:
    PPO
    Gene namesi
    Name:hemY
    Ordered Locus Names:Rv2677c
    ORF Names:MTV010.01c
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001584: Chromosome

    Organism-specific databases

    TubercuListiRv2677c.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Protoporphyrinogen oxidasePRO_0000135265Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer. Homodimer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP9WMP1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protoporphyrinogen oxidase family.Curated

    Phylogenomic databases

    KOiK00231.
    PhylomeDBiP9WMP1.

    Family and domain databases

    Gene3Di3.90.660.20. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P9WMP1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPRSYCVVG GGISGLTSAY RLRQAVGDDA TITLFEPADR LGGVLRTEHI    50
    GGQPMDLGAE AFVLRRPEMP ALLAELGLSD RQLASTGARP LIYSQQRLHP 100
    LPPQTVVGIP SSAGSMAGLV DDATLARIDA EAARPFTWQV GSDPAVADLV 150
    ADRFGDQVVA RSVDPLLSGV YAGSAATIGL RAAAPSVAAA LDRGATSVTD 200
    AVRQALPPGS GGPVFGALDG GYQVLLDGLV RRSRVHWVRA RVVQLERGWV 250
    LRDETGGRWQ ADAVILAVPA PRLARLVDGI APRTHAAARQ IVSASSAVVA 300
    LAVPGGTAFP HCSGVLVAGD ESPHAKAITL SSRKWGQRGD VALLRLSFGR 350
    FGDEPALTAS DDQLLAWAAD DLVTVFGVAV DPVDVRVRRW IEAMPQYGPG 400
    HADVVAELRA GLPPTLAVAG SYLDGIGVPA CVGAAGRAVT SVIEALDAQV 450
    AR 452
    Length:452
    Mass (Da):46,846
    Last modified:April 16, 2014 - v1
    Checksum:i6DFA1F57BEE2810F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP45475.1.
    RefSeqiYP_006516121.1. NC_018143.2.
    YP_177675.1. NC_000962.3.

    Genome annotation databases

    GeneIDi13319404.
    887711.
    KEGGimtu:Rv2677c.
    mtv:RVBD_2677c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP45475.1 .
    RefSeqi YP_006516121.1. NC_018143.2.
    YP_177675.1. NC_000962.3.

    3D structure databases

    ProteinModelPortali P9WMP1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 13319404.
    887711.
    KEGGi mtu:Rv2677c.
    mtv:RVBD_2677c.

    Organism-specific databases

    TubercuListi Rv2677c.

    Phylogenomic databases

    KOi K00231.
    PhylomeDBi P9WMP1.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00324 .

    Family and domain databases

    Gene3Di 3.90.660.20. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37Rv.
    2. "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
      Camus J.-C., Pryor M.J., Medigue C., Cole S.T.
      Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ATCC 25618 / H37Rv.

    Entry informationi

    Entry nameiPPOX_MYCTU
    AccessioniPrimary (citable) accession number: P9WMP1
    Secondary accession number(s): L0TAB5, O53230, P0A5A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2014
    Last sequence update: April 16, 2014
    Last modified: October 1, 2014
    This is version 6 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
      Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3