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P9WMP1

- PPOX_MYCTU

UniProt

P9WMP1 - PPOX_MYCTU

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Protein
Protoporphyrinogen oxidase
Gene
hemY, Rv2677c, MTV010.01c
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX By similarity.

Catalytic activityi

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

Cofactori

Binds 1 FAD per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei390 – 3901FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156FAD By similarity
Nucleotide bindingi36 – 372FAD By similarity
Nucleotide bindingi58 – 614FAD By similarity
Nucleotide bindingi426 – 4283FAD By similarity

GO - Molecular functioni

  1. oxygen-dependent protoporphyrinogen oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00251; UER00324.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoporphyrinogen oxidase (EC:1.3.3.4)
Short name:
PPO
Gene namesi
Name:hemY
Ordered Locus Names:Rv2677c
ORF Names:MTV010.01c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001584: Chromosome

Organism-specific databases

TubercuListiRv2677c.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Protoporphyrinogen oxidase
PRO_0000135265Add
BLAST

Interactioni

Subunit structurei

Monomer. Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP9WMP1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00231.
PhylomeDBiP9WMP1.

Family and domain databases

Gene3Di3.90.660.20. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WMP1-1 [UniParc]FASTAAdd to Basket

« Hide

MTPRSYCVVG GGISGLTSAY RLRQAVGDDA TITLFEPADR LGGVLRTEHI    50
GGQPMDLGAE AFVLRRPEMP ALLAELGLSD RQLASTGARP LIYSQQRLHP 100
LPPQTVVGIP SSAGSMAGLV DDATLARIDA EAARPFTWQV GSDPAVADLV 150
ADRFGDQVVA RSVDPLLSGV YAGSAATIGL RAAAPSVAAA LDRGATSVTD 200
AVRQALPPGS GGPVFGALDG GYQVLLDGLV RRSRVHWVRA RVVQLERGWV 250
LRDETGGRWQ ADAVILAVPA PRLARLVDGI APRTHAAARQ IVSASSAVVA 300
LAVPGGTAFP HCSGVLVAGD ESPHAKAITL SSRKWGQRGD VALLRLSFGR 350
FGDEPALTAS DDQLLAWAAD DLVTVFGVAV DPVDVRVRRW IEAMPQYGPG 400
HADVVAELRA GLPPTLAVAG SYLDGIGVPA CVGAAGRAVT SVIEALDAQV 450
AR 452
Length:452
Mass (Da):46,846
Last modified:April 16, 2014 - v1
Checksum:i6DFA1F57BEE2810F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP45475.1.
RefSeqiYP_006516121.1. NC_018143.2.
YP_177675.1. NC_000962.3.

Genome annotation databases

GeneIDi13319404.
887711.
KEGGimtu:Rv2677c.
mtv:RVBD_2677c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP45475.1 .
RefSeqi YP_006516121.1. NC_018143.2.
YP_177675.1. NC_000962.3.

3D structure databases

ProteinModelPortali P9WMP1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13319404.
887711.
KEGGi mtu:Rv2677c.
mtv:RVBD_2677c.

Organism-specific databases

TubercuListi Rv2677c.

Phylogenomic databases

KOi K00231.
PhylomeDBi P9WMP1.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00324 .

Family and domain databases

Gene3Di 3.90.660.20. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
    Camus J.-C., Pryor M.J., Medigue C., Cole S.T.
    Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiPPOX_MYCTU
AccessioniPrimary (citable) accession number: P9WMP1
Secondary accession number(s): L0TAB5, O53230, P0A5A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 3, 2014
This is version 5 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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