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P9WMP0

- PPOX_MYCTO

UniProt

P9WMP0 - PPOX_MYCTO

Protein

Protoporphyrinogen oxidase

Gene

hemY

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 6 (01 Oct 2014)
      Sequence version 1 (16 Apr 2014)
      Previous versions | rss
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    Functioni

    Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.By similarity

    Catalytic activityi

    Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei242 – 2421FAD; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei390 – 3901FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156FADBy similarity
    Nucleotide bindingi36 – 372FADBy similarity
    Nucleotide bindingi58 – 614FADBy similarity
    Nucleotide bindingi426 – 4283FADBy similarity

    GO - Molecular functioni

    1. oxygen-dependent protoporphyrinogen oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00324.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protoporphyrinogen oxidase (EC:1.3.3.4)
    Short name:
    PPO
    Gene namesi
    Name:hemY
    Ordered Locus Names:MT2751
    OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
    Taxonomic identifieri83331 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001020: Chromosome

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Protoporphyrinogen oxidasePRO_0000427270Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer. Homodimer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP9WMP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protoporphyrinogen oxidase family.Curated

    Phylogenomic databases

    KOiK00231.

    Family and domain databases

    Gene3Di3.90.660.20. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P9WMP0-1 [UniParc]FASTAAdd to Basket

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    MTPRSYCVVG GGISGLTSAY RLRQAVGDDA TITLFEPADR LGGVLRTEHI    50
    GGQPMDLGAE AFVLRRPEMP ALLAELGLSD RQLASTGARP LIYSQQRLHP 100
    LPPQTVVGIP SSAGSMAGLV DDATLARIDA EAARPFTWQV GSDPAVADLV 150
    ADRFGDQVVA RSVDPLLSGV YAGSAATIGL RAAAPSVAAA LDRGATSVTD 200
    AVRQALPPGS GGPVFGALDG GYQVLLDGLV RRSRVHWVRA RVVQLERGWV 250
    LRDETGGRWQ ADAVILAVPA PRLARLVDGI APRTHAAARQ IVSASSAVVA 300
    LAVPGGTAFP HCSGVLVAGD ESPHAKAITL SSRKWGQRGD VALLRLSFGR 350
    FGDEPALTAS DDQLLAWAAD DLVTVFGVAV DPVDVRVRRW IEAMPQYGPG 400
    HADVVAELRA GLPPTLAVAG SYLDGIGVPA CVGAAGRAVT SVIEALDAQV 450
    AR 452
    Length:452
    Mass (Da):46,846
    Last modified:April 16, 2014 - v1
    Checksum:i6DFA1F57BEE2810F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000516 Genomic DNA. Translation: AAK47066.1.
    RefSeqiNP_337252.1. NC_002755.2.

    Genome annotation databases

    GeneIDi925547.
    KEGGimtc:MT2751.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000516 Genomic DNA. Translation: AAK47066.1 .
    RefSeqi NP_337252.1. NC_002755.2.

    3D structure databases

    ProteinModelPortali P9WMP0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 925547.
    KEGGi mtc:MT2751.

    Phylogenomic databases

    KOi K00231.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00324 .

    Family and domain databases

    Gene3Di 3.90.660.20. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CDC 1551 / Oshkosh.

    Entry informationi

    Entry nameiPPOX_MYCTO
    AccessioniPrimary (citable) accession number: P9WMP0
    Secondary accession number(s): L0TAB5, O53230, P0A5A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2014
    Last sequence update: April 16, 2014
    Last modified: October 1, 2014
    This is version 6 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3